INT104331

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 13.68
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1A) nucleoplasm (CDKN1A) nucleus (CDKN1A)
cell cycle (CDKN1A) kinase activity (CDKN1A) cytoplasm (CDKN1A)
Anatomy Link Frequency
Capan-2 4
epithelial cell 4
BxPC-3 3
HT-29 2
cleavage 2
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 45 99.98 Very High Very High Very High
cocaine 292 99.04 Very High Very High Very High
palliative 2 97.96 Very High Very High Very High
withdrawal 19 95.52 Very High Very High Very High
antagonist 38 86.36 High High
COX-2 inhibitor 4 86.08 High High
Kinase C 2 75.00 Quite High
Enkephalin 10 73.20 Quite High
Opioid 65 71.68 Quite High
local anesthetic 1 44.96 Quite Low
Disease Link Frequency Relevance Heat
Cystic Kidney Diseases 36 99.84 Very High Very High Very High
Prostate Cancer 19 99.84 Very High Very High Very High
Targeted Disruption 29 99.64 Very High Very High Very High
Disease 170 99.60 Very High Very High Very High
Apoptosis 653 99.36 Very High Very High Very High
Polycystic Kidney Disease 216 98.02 Very High Very High Very High
Hepatocellular Cancer 44 97.96 Very High Very High Very High
Breast Cancer 53 97.20 Very High Very High Very High
Repression 10 97.12 Very High Very High Very High
Alagille Syndrome 2 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our present findings that ADPKD, which is characterized by increased RTE cell growth, may in fact be a disease which results from diminished p21 expression in affected tissues are consistent with recent data showing that polycystin-1 induces p21 [9] and causes resistance to apoptosis [23].
Negative_regulation (diminished) of Gene_expression (expression) of p21 associated with polycystic kidney disease, apoptosis and disease
1) Confidence 0.57 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.71 Pain Relevance 0
While these investigators also showed that p21 levels were reduced in Pkd1 knockout mice, there has to our knowledge been no published study examining the function of p21 in human tissues or in non-knockout animal models of this disease.
Negative_regulation (reduced) of Gene_expression (levels) of p21 associated with targeted disruption and disease
2) Confidence 0.57 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.81 Pain Relevance 0
Consistent with this finding, our data indicate reduced expression of p21 in cystic kidneys from male, but not female, Han:SPRD rats.
Negative_regulation (reduced) of Gene_expression (expression) of p21 associated with cystic kidney diseases
3) Confidence 0.57 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.57 Pain Relevance 0
Neither estrogen, nor sFasL alone induced an alteration in p21/Waf1 expression, though sFasL-treated cultures exhibited a non-statistically significant trend towards decreased p21/waf-1 expression.
Negative_regulation (decreased) of Gene_expression (expression) of waf-1
4) Confidence 0.57 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.35 Pain Relevance 0
We have found that p53 protein accumulated in a dose- and time-dependent manner after Dx treatment, while p21 expression increased over time with low but decreased with high Dx doses.
Negative_regulation (decreased) of Gene_expression (expression) of p21
5) Confidence 0.42 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12151346 Disease Relevance 1.42 Pain Relevance 0.19
Apoptosis was assessed by PARP cleavage. p21 expression was attenuated in a renal tubular epithelial cell line by antisense methods, and proliferation in response to p21 attenuation and to roscovitine was assessed by the MTT assay.


Negative_regulation (attenuated) of Gene_expression (expression) of p21 in cleavage associated with apoptosis
6) Confidence 0.42 Published 2007 Journal BMC Nephrol Section Abstract Doc Link PMC2045080 Disease Relevance 0.85 Pain Relevance 0
The pre-treatment of cells with CQ inhibited the down-regulation of p21Cip1 and p27Kip1 expressions induced by 5-FU and, on the other hand, inhibited the up-regulation of the expression of CDK2.
Negative_regulation (regulation) of Gene_expression (expressions) of p21Cip1
7) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0 Pain Relevance 0
We observed that IR-induced bax and p21(WAF1/Cip1) protein expression were attenuated selectively in normal stromal and epithelial cell cultures, yet maintained their p53-dependency in malignant cell lines.
Negative_regulation (attenuated) of Gene_expression (expression) of p21 in epithelial cell associated with malignant neoplastic disease
8) Confidence 0.42 Published 2003 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 12664070 Disease Relevance 0.91 Pain Relevance 0.10
Inhibition of PKCbeta(1)-mediated overexpression of p21(waf1/cip1) partially reduced the anti-apoptotic effect of PKCbeta(1).
Negative_regulation (Inhibition) of Gene_expression (overexpression) of waf1 associated with apoptosis
9) Confidence 0.42 Published 2002 Journal Oncogene Section Abstract Doc Link 12203123 Disease Relevance 0.90 Pain Relevance 0.22
However, the concurrent administration of estrogen and sFasL led to a significant decrease in the expression of p21/Waf-1 (Figure 9).
Negative_regulation (decrease) of Gene_expression (expression) of Waf-1
10) Confidence 0.42 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.29 Pain Relevance 0
Renal expression of p21 was significantly attenuated in cystic male rats, as compared with noncystic controls (p < 0.01).
Negative_regulation (attenuated) of Gene_expression (expression) of p21
11) Confidence 0.41 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.44 Pain Relevance 0
Attenuation of p21 results in increased tubular epithelial cell proliferation
Negative_regulation (Attenuation) of Gene_expression (results) of p21 in epithelial cell
12) Confidence 0.41 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.32 Pain Relevance 0
Hence, we analyzed the hepatic expression of cyclin E, CDK2, CDK4 and the cell cycle inhibitor p21cip1/waf1 in animals receiving continuous dietary DAB (HC) and in the HR animals.
Negative_regulation (inhibitor) of Spec (analyzed) Gene_expression (expression) of p21cip1 associated with hepatocellular cancer
13) Confidence 0.41 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.25 Pain Relevance 0.05
Hence, we analyzed the hepatic expression of cyclin E, CDK2, CDK4 and the cell cycle inhibitor p21cip1/waf1 in animals receiving continuous dietary DAB (HC) and in the HR animals.
Spec (analyzed) Negative_regulation (analyzed) of Spec (analyzed) Gene_expression (expression) of p21cip1 associated with hepatocellular cancer
14) Confidence 0.41 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.25 Pain Relevance 0.05
Unexpectedly, concurrent exposure to both estrogen and to sFasL led to a decrease in the expression of both PCNA and p21/waf1.
Negative_regulation (decrease) of Gene_expression (expression) of p21
15) Confidence 0.41 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.47 Pain Relevance 0
Neither estrogen, nor sFasL alone induced an alteration in p21/Waf1 expression, though sFasL-treated cultures exhibited a non-statistically significant trend towards decreased p21/waf-1 expression.
Negative_regulation (decreased) of Gene_expression (expression) of p21
16) Confidence 0.41 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.35 Pain Relevance 0
SiRNA knockdown of p21WAF1/CIP1
Negative_regulation (knockdown) of Gene_expression (/) of p21
17) Confidence 0.41 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0 Pain Relevance 0
Treatment of HT-29 cells with 5-FU resulted in decreased expressions of p21Cip1 and p27Kip1, and simultaneously in increased expression of CDK2.
Negative_regulation (decreased) of Gene_expression (expressions) of p21Cip1 in HT-29
18) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0 Pain Relevance 0
Naloxone abolished the increased expression of p21 protein by OGF, suggesting a receptor-mediated activity. p21 specific siRNAs blocked OGF's repressive action on proliferation in BxPC-3, PANC-1, and Capan-2 cells; cells transfected with negative control siRNA had no alteration in p21 expression, and therefore were inhibited by OGF.


Negative_regulation (abolished) of Gene_expression (expression) of p21 in Capan-2 associated with narcan
19) Confidence 0.37 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2253554 Disease Relevance 0.69 Pain Relevance 0.19
Expression of p21 was evaluated in synchronized BxPC-3 cells after 3, 6, 9, and 12 hours of OGF exposure. p21 was significantly upregulated (p < 0.05) in OGF-treated cells relative to sterile water control cells after 9 hours of drug treatment (Fig. 3A).
Negative_regulation (evaluated) of Gene_expression (Expression) of p21 in BxPC-3
20) Confidence 0.37 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0 Pain Relevance 0

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