INT104396

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Context Info
Confidence 0.55
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 44
Total Number 44
Disease Relevance 14.78
Pain Relevance 8.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
muscle 6
cardiomyocyte 2
striatum 2
kidney 2
neural 2
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 13 100.00 Very High Very High Very High
Morphine 380 99.82 Very High Very High Very High
agonist 105 99.82 Very High Very High Very High
Kinase C 199 99.80 Very High Very High Very High
long-term potentiation 104 99.78 Very High Very High Very High
tolerance 130 98.64 Very High Very High Very High
opioid receptor 343 98.08 Very High Very High Very High
Intracerebroventricular 12 94.36 High High
Opioid 79 93.96 High High
Neurotransmitter 20 93.12 High High
Disease Link Frequency Relevance Heat
Cancer 365 100.00 Very High Very High Very High
Apoptosis 167 100.00 Very High Very High Very High
Injury 94 100.00 Very High Very High Very High
Stress 377 99.98 Very High Very High Very High
Disorder Of Lipid Metabolism 153 99.64 Very High Very High Very High
Diabetes Mellitus 180 99.46 Very High Very High Very High
Mesothelioma 110 99.30 Very High Very High Very High
Hyperglycemia 18 99.10 Very High Very High Very High
Muscular Atrophy 13 98.78 Very High Very High Very High
Insulin Resistance 70 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is most likely because of the time required for the induction of the Akt survival pathway and chaperone upregulation.
Positive_regulation (required) of Positive_regulation (induction) of Akt
1) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515219 Disease Relevance 0.47 Pain Relevance 0
In conclusion, we showed here that the combination of HS and MES treatment ameliorated insulin resistance and decreased fat accumulation in diabetes mouse models, in part, by enhancing Akt activation.


Positive_regulation (enhancing) of Positive_regulation (activation) of Akt in fat associated with diabetes mellitus, shock and insulin resistance
2) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.64 Pain Relevance 0.04
Akt activation is dependent on phosphorylation of two sites: PDK1 phosphorylation of Thr308 in the kinase activation loop and PDK2 phosphorylation of Ser473 at the C-terminus (6).
Positive_regulation (dependent) of Positive_regulation (activation) of Akt
3) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.55
Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors.
Positive_regulation (induced) of Positive_regulation (activation) of AKT in striatum associated with opioid receptor
4) Confidence 0.49 Published 2010 Journal Addict Biol Section Title Doc Link 20456289 Disease Relevance 0 Pain Relevance 0.30
Our previous studies have shown that sustained activation of NGF/PI3K/Akt/NF-kappaB signaling is essential for NGF-induced dor gene expression during neuronal differentiation and that the epigenetic modifications at histone 3 lysine 9 temporally correlate with the dor gene transcription.
Positive_regulation (essential) of Positive_regulation (activation) of Akt in neuronal associated with nerve growth factor
5) Confidence 0.49 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20399742 Disease Relevance 0.09 Pain Relevance 0.52
Other contributing effects of morphine include activation of the survival signal PKB/Akt, inhibition of apoptosis, and promotion of cell cycle progression by increasing cyclin D1.
Positive_regulation (increasing) of Positive_regulation (activation) of PKB/Akt associated with apoptosis and morphine
6) Confidence 0.49 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12154060 Disease Relevance 0.61 Pain Relevance 0.59
Other contributing effects of morphine include activation of the survival signal PKB/Akt, inhibition of apoptosis, and promotion of cell cycle progression by increasing cyclin D1.
Positive_regulation (increasing) of Positive_regulation (activation) of PKB/Akt associated with apoptosis and morphine
7) Confidence 0.49 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12154060 Disease Relevance 0.61 Pain Relevance 0.59
These data suggest that increased PKB/Akt activation triggers hyperphosphorylation and inactivation of GSK3?
Positive_regulation (increased) of Positive_regulation (activation) of PKB/Akt
8) Confidence 0.48 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0 Pain Relevance 0
A previous study has shown that high-tidal-volume ventilation can lead to activation of serine/threonine kinase/protein kinase B (Akt) [18].
Positive_regulation (lead) of Positive_regulation (activation) of Akt
9) Confidence 0.43 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.93 Pain Relevance 0.30
Similar to was observed with cardiomyocyte size, PE stress did not induce additional activation of Akt and NFAT3 in combination with myostatin inhibition, but myostatin overexpression did block PE-induced activation of these pathways.
Neg (not) Positive_regulation (induce) of Positive_regulation (activation) of Akt in cardiomyocyte associated with stress
10) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 0.10 Pain Relevance 0
In this proof-of-principle therapeutic study we showed that VLP administration conferred protection against HgCl2-induced AKI, presumably via activation of the Akt-1 survival pathway and chaperones.
Positive_regulation (conferred) of Positive_regulation (activation) of Akt associated with injury
11) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515219 Disease Relevance 0.50 Pain Relevance 0
The Akt activation was immediately transferred to neural Nitric Oxide Synthase (nNOS) Ser1417.
Positive_regulation (transferred) of Positive_regulation (activation) of Akt in neural
12) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.14 Pain Relevance 0.95
In summary, early activation of Akt and nNOS initiates the PKC?
Positive_regulation (initiates) of Positive_regulation (activation) of Akt associated with kinase c
13) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.11
Furthermore, upregulation of the PI3K-Akt pathway in mutant mice lacking phosphatase and tensin homolog, a lipid phosphatase counteracting PI3K, selectively enhanced chronic desensitization in a PI3K- and MAPK-dependent manner.
Positive_regulation (enhanced) of Positive_regulation (upregulation) of Akt
14) Confidence 0.36 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614088 Disease Relevance 0.08 Pain Relevance 0.34
These data suggest that increased PKB/Akt activation triggers hyperphosphorylation and inactivation of GSK3?
Positive_regulation (inactivation) of Positive_regulation (activation) of PKB/Akt
15) Confidence 0.35 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0 Pain Relevance 0
These data suggest that PKB/Akt activation may be increased in the absence of IRS2 in kidney.
Positive_regulation (increased) of Positive_regulation (activation) of PKB/Akt in kidney
16) Confidence 0.35 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0 Pain Relevance 0
Phosphorylation of both Ser473 and Thr308 residues contribute to Akt activation [32].
Positive_regulation (contribute) of Positive_regulation (activation) of Akt
17) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.34
Therefore, while the increased activation of PKB in the overloaded PLN muscle of the PTEN?
Positive_regulation (increased) of Positive_regulation (activation) of PKB in muscle
18) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.27 Pain Relevance 0
The absence of PI3K activation together with the requirement for PI(3,4,5,)P3 observed by Sakamoto suggested that inactivation of PTEN [51] could be important in contraction mediated PKB activation.
Positive_regulation (mediated) of Positive_regulation (activation) of PKB
19) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.09 Pain Relevance 0
Insulin and insulin-like growth factor activation of mTORC1 is dependent on the activation of the IGF-1 receptor [44], the generation of PI(3,4,5)P3 at the membrane, and the subsequent activation of PKB [45], [46].
Positive_regulation (dependent) of Positive_regulation (activation) of PKB
20) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.17 Pain Relevance 0

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