INT104567

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 47
Total Number 67
Disease Relevance 44.84
Pain Relevance 28.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp1) transmembrane transporter activity (Aqp1) plasma membrane (Aqp1)
nucleus (Aqp1) transmembrane transport (Aqp1) cytoplasm (Aqp1)
Anatomy Link Frequency
spinal cord 8
dorsal horn 5
cerebrospinal fluid 4
neurons 4
tanycytes 3
Aqp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 520 99.96 Very High Very High Very High
Peripheral nervous system 246 99.96 Very High Very High Very High
nociceptor 80 99.92 Very High Very High Very High
c fibre 76 99.84 Very High Very High Very High
nav1.8 84 99.80 Very High Very High Very High
calcitonin gene related peptide 21 99.76 Very High Very High Very High
Dorsal horn 176 99.68 Very High Very High Very High
substance P 65 99.60 Very High Very High Very High
Migraine 861 99.44 Very High Very High Very High
Sciatic nerve 65 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 217 100.00 Very High Very High Very High
Brain Tumor 68 99.98 Very High Very High Very High
Nociception 316 99.92 Very High Very High Very High
Frailty 136 99.82 Very High Very High Very High
Headache 756 99.44 Very High Very High Very High
Hypoxia 92 99.40 Very High Very High Very High
Inflammatory Pain 77 99.40 Very High Very High Very High
Contusions 29 99.32 Very High Very High Very High
Motor Neuron Diseases 323 99.20 Very High Very High Very High
Injury 363 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aquaporin-1 (AQP1), a membrane water channel, is expressed in choroid plexus where it contributes to cerebrospinal fluid production.
Gene_expression (expressed) of AQP1 in cerebrospinal fluid
1) Confidence 0.78 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16476579 Disease Relevance 0.29 Pain Relevance 0.54
Aquaporin-1 (AQP1), a membrane water channel, is expressed in choroid plexus where it contributes to cerebrospinal fluid production.
Gene_expression (expressed) of Aquaporin-1 in cerebrospinal fluid
2) Confidence 0.78 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16476579 Disease Relevance 0.29 Pain Relevance 0.54
These results provide evidence for AQP1 expression in nociceptive neurons and suggest that AQP1 may play a role in pain signal transduction.
Gene_expression (expression) of AQP1 in neurons associated with nociception and pain
3) Confidence 0.78 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16476579 Disease Relevance 0.54 Pain Relevance 0.74
Here, we show that AQP1 is also expressed in the dorsal horn of the spinal cord and the trigeminal nucleus caudalis, regions that process pain information.
Gene_expression (expressed) of AQP1 in spinal cord associated with pain, dorsal horn and spinal cord
4) Confidence 0.78 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16476579 Disease Relevance 0.37 Pain Relevance 0.60
AQP1 expression in DRG is first detectable at embryonic day 15.5, which corresponds to the developmental stage when the majority of fine cutaneous afferents penetrate the dorsal horn.
Gene_expression (expression) of AQP1 in developmental stage associated with dorsal horn
5) Confidence 0.78 Published 2007 Journal Pain Section Abstract Doc Link 17257750 Disease Relevance 0.12 Pain Relevance 0.33
In the present study, we used immunohistochemistry to show that AQP1 is heavily expressed in a population of small diameter primary sensory neurons of dorsal root, trigeminal, and nodose ganglia.
Gene_expression (expressed) of AQP1 in ganglia
6) Confidence 0.78 Published 2007 Journal Pain Section Abstract Doc Link 17257750 Disease Relevance 0 Pain Relevance 0.18
The possible roles of increased expression of AQP-1 in the etiology of different neuropathological conditions are still unknown, but it is likely that AQP-1 up-regulation may contribute to edema and cyst formation-typical outcomes in most of these pathological conditions.
Gene_expression (expression) of AQP-1 associated with pressure and volume under development and cyst
7) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.64 Pain Relevance 0.18
Interestingly, GFAP-positive, injured Schwann cells in the peripheral nervous system (PNS) are known to express AQP-1 [54], but not AQP-4, a protein abundant in spinal cord astrocytes [55].
Neg (not) Gene_expression (express) of AQP-1 in astrocytes associated with peripheral nervous system and spinal cord
8) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.77 Pain Relevance 1.19
Unfortunately, the mechanisms that control AQP-1 gene expression in the CNS, under normal or pathological conditions, are still poorly understood.
Gene_expression (expression) of AQP-1 gene
9) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.53 Pain Relevance 0.17
In all cases, the elevated AQP-1 expression seems to occur in astrocytes residing in diseased brain tissue, even though these astrocytes and other glial cells do not normally express AQP-1.
Neg (not) Gene_expression (express) of AQP-1 in glial cells
10) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.64 Pain Relevance 0.19
In all cases, the elevated AQP-1 expression seems to occur in astrocytes residing in diseased brain tissue, even though these astrocytes and other glial cells do not normally express AQP-1.
Gene_expression (expression) of AQP-1 in glial cells
11) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.65 Pain Relevance 0.20
Brain AQP-1 is mainly expressed in the cerebrospinal fluid (CSF)-facing membranes of the ventricular choroid plexus, where it regulates the formation of CSF presumably due to its functions as a water pore and ion channel [40].
Gene_expression (expressed) of AQP-1 in choroid plexus
12) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.53 Pain Relevance 0.27
Moreover, in CNS, hypertonicity induces AQP-1 synthesis via extracellular signal-regulated kinases, p38 kinase, and c-Jun terminal kinase [44].
Gene_expression (synthesis) of AQP-1
13) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.55 Pain Relevance 0.25
Interestingly, various neuropathological conditions involve the up-regulation of AQP-1 expression in the CNS.
Gene_expression (expression) of AQP-1
14) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.62 Pain Relevance 0.23
Considering the expression of AQP-1 in the dorsal horn, it has been suggested that AQP-1 has a role in physiological pain sensation, known as nociception.
Gene_expression (expression) of AQP-1 in dorsal horn associated with nociception, pain, dorsal horn and painful pain
15) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.76 Pain Relevance 0.46
In the spinal cord, AQP-1 is also expressed in the ependymal cells lining the central canal, but more robustly in the sensory fibers of the superficial laminae of the dorsal horn [45-47].
Gene_expression (expressed) of AQP-1 in central canal associated with dorsal horn and spinal cord
16) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.62 Pain Relevance 0.37
These data provide a physical and functional link between AQP-1 expression and Nav1.8 function, and implicate the involvement of AQP1 in DRG neurons for the perception of inflammatory thermal pain [53].
Gene_expression (expression) of AQP-1 in neurons associated with pain, inflammation and nav1.8
17) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.53 Pain Relevance 1.24
AQP-1 is expressed in small afferent sensory nerve fibers in the peripheral nervous system.
Gene_expression (expressed) of AQP-1 in sensory nerve associated with peripheral nervous system
18) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.79 Pain Relevance 1.09
Upregulation of brain AQP-1 expression is found in Alzheimer patients [41], Creutzfeldt-Jakob disease [42], traumatic brain injury patients, and human hemangioblastomas.
Gene_expression (expression) of AQP-1 in brain associated with hemangioblastoma, disease and brain injury
19) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.64 Pain Relevance 0.23
It is intriguing that dorsal root stimulation results in activity-dependent water flux specifically in the superficial dorsal horn of the spinal cord where AQP1 is expressed.
Gene_expression (expressed) of AQP1 in spinal cord associated with dorsal horn and spinal cord
20) Confidence 0.72 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.54 Pain Relevance 0.91

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