INT1046

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Context Info
Confidence 0.77
First Reported 1970
Last Reported 2010
Negated 2
Speculated 6
Reported most in Abstract
Documents 180
Total Number 188
Disease Relevance 29.75
Pain Relevance 66.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 31
follicle 9
blood 8
medial 5
pituitary 5
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 133 100.00 Very High Very High Very High
opiate 105 100.00 Very High Very High Very High
depression 39 100.00 Very High Very High Very High
Hippocampus 37 100.00 Very High Very High Very High
monoamine 23 100.00 Very High Very High Very High
antinociception 17 100.00 Very High Very High Very High
Clonidine 11 100.00 Very High Very High Very High
narcan 304 99.98 Very High Very High Very High
agonist 256 99.98 Very High Very High Very High
butorphanol 6 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 42 100.00 Very High Very High Very High
Aids-related Complex 22 100.00 Very High Very High Very High
Sprains And Strains 220 99.96 Very High Very High Very High
Generalized Anxiety Disorder 78 99.96 Very High Very High Very High
Stress 613 99.82 Very High Very High Very High
Primary Sclerosing Cholangitis 54 99.82 Very High Very High Very High
Urological Neuroanatomy 98 99.56 Very High Very High Very High
Hemorrhage 5 99.52 Very High Very High Very High
Necrosis 11 99.46 Very High Very High Very High
Diabetes Mellitus 100 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The exogenous opioid morphine blocked the increase in LH produced by naloxone in a dose-dependent fashion, suggesting that the specific receptor-blocking effects of the antagonist could account for its enhancement of serum LH levels.
Gene_expression (produced) of LH associated with antagonist, narcan, opioid and morphine
1) Confidence 0.77 Published 1979 Journal Endocrinology Section Abstract Doc Link 374068 Disease Relevance 0 Pain Relevance 0.63
Two narcotic antagonists, naloxone and naltrexone, significantly elevated serum LH levels in male rats within minutes after their sc injection.
Gene_expression (levels) of LH associated with antagonist and narcan
2) Confidence 0.77 Published 1979 Journal Endocrinology Section Abstract Doc Link 374068 Disease Relevance 0 Pain Relevance 0.47
The pro-oestrous secretion of progesterone that follows the LH surge in the rat limits the expression of the daily signal for LH surge initiation until the following oestrous cycle.
Gene_expression (expression) of LH
3) Confidence 0.77 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 3379356 Disease Relevance 0 Pain Relevance 0.09
In previous studies, it was demonstrated that morphine pellet implantation markedly sensitized adult male rats to the subsequent elevations in serum luteinizing hormone (LH) levels produced by the opiate antagonist, naloxone.
Gene_expression (produced) of LH associated with antagonist, narcan, opiate and morphine
4) Confidence 0.77 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3528453 Disease Relevance 0.07 Pain Relevance 0.71
At this time, serum LH levels were 5 times greater in naloxone-treated males than in controls, and were twice those found in similarly treated females.
Gene_expression (levels) of LH associated with narcan
5) Confidence 0.74 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3512817 Disease Relevance 0.08 Pain Relevance 0.74
Bilateral lesions of the medial region of the PAG, which did not encroach upon the dorsal raphe nucleus, elevated basal levels of serum LH.
Gene_expression (levels) of serum LH in PAG associated with urological neuroanatomy and raphe
6) Confidence 0.74 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 7022252 Disease Relevance 0.79 Pain Relevance 1.01
Bolus intraventricular injection of other endogenous opioid peptides and opiate receptor agonists produced different PRL and LH responses.
Gene_expression (produced) of LH associated with agonist, endogenous opioid and opiate
7) Confidence 0.70 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 4047342 Disease Relevance 0 Pain Relevance 0.73
Equimolar concentrations (10(-7)M ) of methionine enkephaline (Met-Enk) and D-ala2-met-enkephalinamide (DALA) produced a significant decrease in LH.
Gene_expression (produced) of LH
8) Confidence 0.68 Published 1986 Journal Life Sci. Section Abstract Doc Link 2935695 Disease Relevance 0 Pain Relevance 0.49
In contrast, naloxone was able to increase LH levels in TP-treated castrated rats even at the highest dose tested (50 mg/kg).
Gene_expression (levels) of LH associated with narcan
9) Confidence 0.68 Published 1985 Journal Steroids Section Abstract Doc Link 3842024 Disease Relevance 0 Pain Relevance 0.66
For LH assays, 0.3 ml blood was collected via an atrial cannula 15 min after drug treatment and every 15 min thereafter for 3 h.
Gene_expression (assays) of LH in blood
10) Confidence 0.68 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6122171 Disease Relevance 0 Pain Relevance 0.56
More prolonged etherization (15 minutes) significantly depressed circulating LH, whereas naltrexone ( NALT ), a specific opiate antagonist, reversed this decline.
Gene_expression (depressed) of LH associated with antagonist and opiate
11) Confidence 0.67 Published 1984 Journal Life Sci. Section Abstract Doc Link 6374352 Disease Relevance 0.39 Pain Relevance 0.40
Plasma LH and T levels in each sample were measured by radioimmunoassay (RIA).
Gene_expression (levels) of Plasma LH in Plasma
12) Confidence 0.67 Published 1984 Journal Biol. Reprod. Section Abstract Doc Link 6478013 Disease Relevance 0.07 Pain Relevance 0.09
Moreover, in the majority (62%) of rats perfused with nor-BNI in the MPOA, the final 1.5 h of perfusion were unexpectedly characterized by an increase in LH that was of greater magnitude and more prolonged than an LH pulse and produced an elevation in blood LH levels.
Gene_expression (prolonged) of LH in MPOA associated with urological neuroanatomy
13) Confidence 0.67 Published 1992 Journal Endocrinology Section Abstract Doc Link 1327717 Disease Relevance 0.56 Pain Relevance 0.28
Mean LH levels in DES-exposed females were lower than in controls before GnRH administration and were blunted following GnRH.
Gene_expression (levels) of LH
14) Confidence 0.67 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8485248 Disease Relevance 0 Pain Relevance 0.72
Serum LH levels in rats castrated 5 days earlier were significantly reduced by intracerebroventricular administration of homologous (rat) CRF (0.02-2 nmol) within 30 min posttreatment; the effects of 0.02 nmol CRF lasted for at least 2 h, whereas those of 0.2 and 2 nmol CRF were evident for up to 6 h.
Gene_expression (levels) of Serum LH associated with intracerebroventricular
15) Confidence 0.67 Published 1988 Journal Endocrinology Section Abstract Doc Link 3257730 Disease Relevance 0 Pain Relevance 0.36
The peak plasma LH levels after each NMDA injection and the cumulative LH responses were significantly higher in peptide-treated than in control rats.
Gene_expression (levels) of LH in plasma
16) Confidence 0.66 Published 1994 Journal J. Neuroendocrinol. Section Abstract Doc Link 7827626 Disease Relevance 0 Pain Relevance 0.78
The evidence suggests that the preovulatory LH surge may occur in an episodic fashion and that it can be reproduced by LHRH delivered at a frequency rate of LH pulses seen in ovariectomized rats.
Gene_expression (pulses) of LH
17) Confidence 0.66 Published 1988 Journal Endocrinology Section Abstract Doc Link 3125034 Disease Relevance 0 Pain Relevance 0.33
During inescapable NGC stimulation, rates of lever-pressing for LH trains were greatest when LH pulses preceded NGC pulses again at intervals of 0.1 or 10 ms.
Gene_expression (lever-pressing) of LH in lever
18) Confidence 0.65 Published 1982 Journal Brain Res. Section Abstract Doc Link 7188027 Disease Relevance 0 Pain Relevance 0.09
Effects of LH-RH on serum LH levels were studied during pregnancy in rats.
Gene_expression (levels) of LH
19) Confidence 0.64 Published 1983 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 6352835 Disease Relevance 0.08 Pain Relevance 0.17
The failure of ibotenic acid to affect LH-produced descending inhibition when microinjected into the dorsolateral pons, and the significant effect produced by lidocaine microinjected into the same area, implicates fibers of passage in the dorsolateral pons in descending inhibition of the TF reflex produced by focal electrical stimulation in the LH.
Gene_expression (produced) of LH-produced in pons associated with tail-flick and lidocaine
20) Confidence 0.64 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 3249250 Disease Relevance 0.17 Pain Relevance 0.82

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