INT104663

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.42
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN9A)
Anatomy Link Frequency
neural 1
SCN9A (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 21 100.00 Very High Very High Very High
sodium channel 15 100.00 Very High Very High Very High
Nav1.1 8 100.00 Very High Very High Very High
Nav1.6 7 100.00 Very High Very High Very High
nav1.3 7 100.00 Very High Very High Very High
Pain 7 100.00 Very High Very High Very High
Nav1.2 5 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
potassium channel 4 99.76 Very High Very High Very High
Nav1.7 7 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroma 2 98.32 Very High Very High Very High
Pain 3 83.36 Quite High
Dysesthesia 1 83.00 Quite High
Obesity 19 75.00 Quite High
Sperm Disorder 15 32.56 Quite Low
Nociception 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accumulation of PN1 and PN3 sodium channels in painful human neuroma-evidence from immunocytochemistry.
Positive_regulation (Accumulation) of PN1 associated with pain, neuropeptide, sodium channel and neuroma
1) Confidence 0.60 Published 2002 Journal Acta Neurochir (Wien) Section Title Doc Link 12181690 Disease Relevance 0.35 Pain Relevance 0.78
subunits are inhibited by TTX in the nanomolar range and include SCN1A (also known as Nav1.1), SCN2A (also known as Nav1.2), SCN3A (also known as Nav1.3), SCN4A (also known as Nav1.4), SCN8A (also known as Nav1.6), and SCN9A (also known as Nav1.7).
Positive_regulation (include) of SCN9A associated with nav1.3, tetrodotoxin, nav1.1, nav1.2, nav1.7 and nav1.6
2) Confidence 0.48 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 1.35
In addition, we demonstrated that Kv4.3 and Eag1, potassium channel genes, and NE-Na, a TTX-sensitive sodium channel gene, were highly induced following neural differentiation.


Positive_regulation (induced) of NE-Na in neural associated with tetrodotoxin, sodium channel and potassium channel
3) Confidence 0.08 Published 2010 Journal BMC Cell Biol Section Abstract Doc Link PMC2867791 Disease Relevance 0.07 Pain Relevance 0.41

General Comments

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