INT104688

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Context Info
Confidence 0.15
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.22
Pain Relevance 8.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 4
embryonic kidney 4
Mors1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 277 100.00 Very High Very High Very High
mu opioid receptor 202 100.00 Very High Very High Very High
Spinal cord 92 99.60 Very High Very High Very High
Pain 36 99.60 Very High Very High Very High
Antinociceptive 148 99.20 Very High Very High Very High
Dorsal horn 27 98.96 Very High Very High Very High
tolerance 158 98.32 Very High Very High Very High
narcan 184 97.88 Very High Very High Very High
agonist 15 94.40 High High
Delta opioid receptors 1 91.56 High High
Disease Link Frequency Relevance Heat
Pain 48 99.60 Very High Very High Very High
Substance Withdrawal Syndrome 10 78.00 Quite High
Targeted Disruption 51 76.72 Quite High
Drug Dependence 10 54.96 Quite High
Toxicity 5 48.12 Quite Low
Death 1 20.00 Low Low
Apoptosis 1 14.40 Low Low
Urological Neuroanatomy 18 5.00 Very Low Very Low Very Low
Injury 16 5.00 Very Low Very Low Very Low
Vomiting 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The productive binding of morphine to MORs induces the release of free G??
Positive_regulation (induces) of Gene_expression (productive) of MORs associated with morphine
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.09
Activation of mu-opioid receptors (MORs) transfected into human embryonic kidney 293 cells, caused a multiphasic increase in cytosolic free Ca(2+) levels (Ca(2+)i).
Positive_regulation (Activation) of Gene_expression (transfected) of MORs in embryonic kidney associated with mu opioid receptor
2) Confidence 0.12 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183657 Disease Relevance 0 Pain Relevance 0.09
Activation of mu-opioid receptors (MORs) transfected into human embryonic kidney 293 cells, caused a multiphasic increase in cytosolic free Ca(2+) levels (Ca(2+)i).
Positive_regulation (transfected) of Gene_expression (transfected) of MORs in embryonic kidney associated with mu opioid receptor
3) Confidence 0.12 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183657 Disease Relevance 0 Pain Relevance 0.09
Significant green fluorescence that represented the expression of MORS196A could be observed in the dorsal horn of sacral spinal cord (Fig. 2D).
Positive_regulation (represented) of Gene_expression (expression) of MORS196A in spinal cord associated with dorsal horn and spinal cord
4) Confidence 0.08 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2883971 Disease Relevance 0.07 Pain Relevance 0.60
We found that morphine at a dose of 10 mg/kg did not have significant antinociceptive effect in MOR-KO mice before they were transfected with the MORS196A-EGFP gene.
Positive_regulation (transfected) of Gene_expression (transfected) of MORS196A-EGFP associated with mu opioid receptor, antinociceptive and morphine
5) Confidence 0.08 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2883971 Disease Relevance 0.19 Pain Relevance 1.53
In vivo transfecting the MORS196A gene into the pain related nervous pathway and systemically administering naloxone activated the local expressed mutant MOR and induced antinociceptive effect without tolerance.
Positive_regulation (transfecting) of Gene_expression (transfecting) of MORS196A gene associated with pain, tolerance, mu opioid receptor, narcan and antinociceptive
6) Confidence 0.07 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2883971 Disease Relevance 0.46 Pain Relevance 1.59
Transfecting the MORS196A gene into the spinal cord and systemically administering naloxone in MOR-KO mice activated the exogenously delivered mutant MOR and provided antinociceptive effect without causing tolerance.
Positive_regulation (Transfecting) of Gene_expression (Transfecting) of MORS196A gene in spinal cord associated with tolerance, mu opioid receptor, narcan, antinociceptive and spinal cord
7) Confidence 0.07 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2883971 Disease Relevance 0.30 Pain Relevance 1.96
However, after 21 days transfection of MORS196A-EGFP gene, 10 mg/kg (s.c.) morphine showed significant antinociceptive effect.
Positive_regulation (transfection) of Gene_expression (transfection) of MORS196A-EGFP associated with antinociceptive and morphine
8) Confidence 0.07 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2883971 Disease Relevance 0.19 Pain Relevance 1.77

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