INT104807

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Context Info
Confidence 0.74
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.67
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TK1) small molecule metabolic process (TK1) kinase activity (TK1)
cytoplasm (TK1)
Anatomy Link Frequency
TK-1 4
TK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 98 97.92 Very High Very High Very High
Chronic pancreatitis 4 95.96 Very High Very High Very High
imagery 74 93.36 High High
peripheral neuropathy 10 12.40 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 20 99.84 Very High Very High Very High
Cancer 102 99.64 Very High Very High Very High
Breast Cancer 112 98.48 Very High Very High Very High
Lung Cancer 6 96.56 Very High Very High Very High
Pancreatitis 4 95.96 Very High Very High Very High
Non-small-cell Lung Cancer 8 95.44 Very High Very High Very High
Immunotherapy Of Cancer 2 93.68 High High
Malignant Neoplastic Disease 4 78.12 Quite High
Toxicity 36 68.76 Quite High
Carcinoma 12 14.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, TK-1 was overexpressed in human pancreatic cancer as compared with normal pancreatic tissue and samples from patients with chronic pancreatitis.
Gene_expression (overexpressed) of TK-1 in TK-1 associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.74 Published 2002 Journal Eur. J. Nucl. Med. Mol. Imaging Section Abstract Doc Link 12192562 Disease Relevance 0.78 Pain Relevance 0.17
TK-1, as the rate-limiting enzyme of [(18)F]FLT metabolism, is overexpressed in pancreatic cancer cell lines and in human pancreatic cancer.
Gene_expression (overexpressed) of TK-1 in TK-1 associated with pancreatic cancer
2) Confidence 0.74 Published 2002 Journal Eur. J. Nucl. Med. Mol. Imaging Section Abstract Doc Link 12192562 Disease Relevance 0.64 Pain Relevance 0.10
TK-1: thymidine kinase-1
Gene_expression (thymidine) of TK-1 in TK-1
3) Confidence 0.29 Published 2007 Journal BMC Nucl Med Section Body Doc Link PMC1931583 Disease Relevance 0.26 Pain Relevance 0.27
Consequently, TK-1 is closely associated with DNA synthesis and is significantly increased in rapidly proliferating cells and therefore is over-expressed in many tumors.
Gene_expression (expressed) of TK-1 in TK-1 associated with cancer
4) Confidence 0.26 Published 2007 Journal BMC Nucl Med Section Body Doc Link PMC1931583 Disease Relevance 0.79 Pain Relevance 0.38
Notably WalBC cells showed up regulated expression of DSP, s100A4, ANXA1, NDRG-1, TK1 and down regulation of genes such as tissue inhibitor of TIMP-3 and TAGLN.
Gene_expression (expression) of TK1
5) Confidence 0.20 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 0.40 Pain Relevance 0
WalBC cells exhibited expression of known markers of basal invasive human breast cancers as well as increased KRT17, KRT 14 and KRT 19, DSP, s100A4, NDRG-1, ANXA1, TK1 and AQP3 gene expression and decreased gene expression of TIMP3, VIM and TAGLN.
Gene_expression (expression) of TK1 associated with breast cancer
6) Confidence 0.20 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2263075 Disease Relevance 0.80 Pain Relevance 0

General Comments

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