INT10483

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Context Info
Confidence 0.62
First Reported 1992
Last Reported 2007
Negated 1
Speculated 3
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 0.73
Pain Relevance 5.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp1r1b) nucleus (Ppp1r1b) intracellular (Ppp1r1b)
cytoplasm (Ppp1r1b)
Anatomy Link Frequency
neurons 2
brain 2
Ppp1r1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 24 100.00 Very High Very High Very High
Dopamine 22 100.00 Very High Very High Very High
agonist 19 100.00 Very High Very High Very High
monoamine 6 100.00 Very High Very High Very High
Kappa opioid receptor 5 99.84 Very High Very High Very High
tetrodotoxin 1 99.70 Very High Very High Very High
Opioid 1 99.70 Very High Very High Very High
Morphine 11 99.04 Very High Very High Very High
Enkephalin 7 97.72 Very High Very High Very High
adenocard 10 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dyskinesias 5 99.40 Very High Very High Very High
Urological Neuroanatomy 4 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblot experiments demonstrated that chronic lithium regulation of DARPP-32 back-phosphorylation is associated with equivalent increases in levels of DARPP-32 immunoreactivity.
Regulation (regulation) of Phosphorylation (phosphorylation) of DARPP-32
1) Confidence 0.62 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1494903 Disease Relevance 0.29 Pain Relevance 0.22
These results suggest that regulation of DARPP-32 phosphorylation is involved in mediating some of the effects exerted by enkephalin on striatal medium-sized spiny neurons.
Regulation (regulation) of Phosphorylation (phosphorylation) of DARPP-32 in neurons associated with enkephalin
2) Confidence 0.61 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.72
In this study, we have examined the contribution of mu-, delta- and kappa-opioid receptors to the regulation of DARPP-32 phosphorylation, in rat striatal slices.
Regulation (regulation) of Phosphorylation (phosphorylation) of DARPP-32 associated with kappa opioid receptor
3) Confidence 0.61 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.54
The kappa-receptor agonist, U50488, does not affect DARPP-32 phosphorylation induced by either D1 or A2A agonists.
Neg (not) Regulation (affect) of Phosphorylation (phosphorylation) of DARPP-32 associated with agonist
4) Confidence 0.61 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.74
Alterations of CREB and DARPP-32 phosphorylation following cocaine and monoaminergic uptake inhibitors.
Regulation (Alterations) of Phosphorylation (phosphorylation) of DARPP-32 associated with monoamine and cocaine
5) Confidence 0.56 Published 2007 Journal Brain Res. Section Title Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.41
In this study, we have examined the contribution of the kappa opioid system to the regulation of DARPP-32 phosphorylation at Thr(34), following acute cocaine administration, in selected rat brain areas.
Spec (examined) Regulation (regulation) of Phosphorylation (phosphorylation) of DARPP-32 in brain associated with opioid and cocaine
6) Confidence 0.44 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.64
Since multiple cAMP response element (CRE) sequences are present on the prodynorphin gene promoter, the aim of our study was to investigate the effects of cocaine and monoaminergic uptake inhibitors on CREB and DARPP-32 phosphorylation and moreover the possible correlation with the changes already observed on prodynorphin gene expression.
Spec (investigate) Regulation (effects) of Phosphorylation (phosphorylation) of DARPP-32 associated with monoamine and cocaine
7) Confidence 0.41 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.57
In order to explore the potential mechanism(s) involved in the over-activation of direct striatal pathways, this study was designed to examine changes in prodynorphin (PDyn) gene expression as well as phosphorylation of dopamine and 32 kDa cAMP-regulated phosphoprotein (DARPP-32) in rats with LID using in situ hybridization and immunoblotting.
Spec (examine) Regulation (changes) of Spec (examine) Phosphorylation (phosphorylation) of DARPP-32 associated with dopamine and dyskinesias
8) Confidence 0.26 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17884291 Disease Relevance 0.44 Pain Relevance 0.09
Dopamine and cyclic AMP-regulated phosphoprotein-32 phosphorylation pattern in cocaine and morphine-sensitized rats.
Regulation (regulated) of Phosphorylation (phosphorylation) of phosphoprotein-32 associated with dopamine, morphine and cocaine
9) Confidence 0.23 Published 2004 Journal J. Neurochem. Section Title Doc Link 15287884 Disease Relevance 0 Pain Relevance 1.03
Tetrodotoxin abolished the effect of quinpirole on the D1 agonist-induced but not the A2A agonist-induced phosphorylation of DARPP-32.
Regulation (effect) of Phosphorylation (phosphorylation) of DARPP-32 associated with tetrodotoxin and agonist
10) Confidence 0.22 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336115 Disease Relevance 0 Pain Relevance 0.85

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