INT10505

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Context Info
Confidence 0.62
First Reported 1988
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 10.70
Pain Relevance 6.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr)
signal transducer activity (Ptafr)
Anatomy Link Frequency
platelet 15
brain 2
sympathetic 1
vagus nerve 1
Ptafr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 79 100.00 Very High Very High Very High
Inflammatory mediators 4 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
vagus nerve 1 99.66 Very High Very High Very High
qutenza 22 99.32 Very High Very High Very High
bradykinin 15 99.26 Very High Very High Very High
Analgesic 1 98.36 Very High Very High Very High
chemokine 1 97.80 Very High Very High Very High
cytokine 25 96.92 Very High Very High Very High
lidocaine 1 96.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 88 100.00 Very High Very High Very High
Nicotine Addiction 28 99.84 Very High Very High Very High
Inflammatory Bowel Disease 25 99.70 Very High Very High Very High
Hypoxia 2 98.64 Very High Very High Very High
Pancreatitis 11 98.48 Very High Very High Very High
Asthma 78 95.16 Very High Very High Very High
Disease 36 95.12 Very High Very High Very High
Genetic Predisposition To Disease 1 93.68 High High
Ulcers 15 91.68 High High
Nociception 2 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Various treatments (chemical sympathectomy, co-perfusion with the local anesthetic lidocaine, or co-perfusion with depolarizing concentrations of potassium) similarly modulated plasma extravasation induced by both bradykinin and 6-hydroxydopamine, but not that produced by platelet activating factor.
Neg (not) Gene_expression (produced) of platelet activating factor in platelet associated with bradykinin, lidocaine and local anesthetic
1) Confidence 0.62 Published 1993 Journal Neuroscience Section Abstract Doc Link 8232896 Disease Relevance 0.16 Pain Relevance 0.45
Ruthenium red did not reduce the amount of plasma extravasation produced by electrical stimulation of the vagus nerve, nor the amount produced by intravenous substance P or platelet-activating factor. 5.
Gene_expression (produced) of platelet-activating factor in vagus nerve associated with vagus nerve and substance p
2) Confidence 0.59 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7590082 Disease Relevance 0.07 Pain Relevance 0.82
Nizatidine treatment did not significantly affect mucosal leukotriene B4, leukotriene C4 or platelet activating factor generation.
Gene_expression (generation) of platelet activating factor in platelet
3) Confidence 0.57 Published 1994 Journal Isr. J. Med. Sci. Section Abstract Doc Link 7960687 Disease Relevance 0.64 Pain Relevance 0.21
Region-specific increases in brain levels of APP, neurofilament-70 (NF-70), and platelet-activating factor receptor (PAF-R) were found in EC rats.
Gene_expression (levels) of platelet-activating factor receptor in brain
4) Confidence 0.55 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12492435 Disease Relevance 0.37 Pain Relevance 0.22
Region-specific increases in brain levels of APP, neurofilament-70 (NF-70), and platelet-activating factor receptor (PAF-R) were found in EC rats.
Gene_expression (levels) of PAF-R in brain
5) Confidence 0.55 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12492435 Disease Relevance 0.37 Pain Relevance 0.22
This circuit inhibits sympathetic neuron-dependent plasma extravasation (PE) in the rat knee joint produced by bradykinin (BK), but not sympathetic neuron-independent PE produced by platelet activating factor (PAF).
Gene_expression (produced) of platelet activating factor in sympathetic associated with bradykinin
6) Confidence 0.40 Published 1998 Journal J. Neurophysiol. Section Abstract Doc Link 9862910 Disease Relevance 0.30 Pain Relevance 0.41
Pancreatic production of lipid mediators of inflammation, including eicosanoids and platelet-activating factor (PAF), was examined in two models of pancreatitis in the rat.
Spec (examined) Gene_expression (production) of platelet-activating factor in platelet associated with inflammation and pancreatitis
7) Confidence 0.38 Published 1994 Journal J. Surg. Res. Section Abstract Doc Link 8277767 Disease Relevance 0.59 Pain Relevance 0.33
The pathophysiology of inflammatory bowel disease (IBD) involves the production of diverse lipid mediators, namely eicosanoids, lysophospholipids, and platelet-activating factor, in which phospholipase A2 (PLA2) is the key enzyme.
Gene_expression (production) of platelet-activating factor in platelet associated with inflammatory bowel disease and inflammation
8) Confidence 0.29 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12724134 Disease Relevance 0.48 Pain Relevance 0.09
Smoking increases production of platelet activating factor (PAF) and endothelin, which are potent gastric ulcerogens.
Gene_expression (production) of platelet activating factor in platelet associated with nicotine addiction
9) Confidence 0.22 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.34 Pain Relevance 0.53
Neither cyclooxygenase products nor platelet-activating factor was involved in capsaicin-induced dilation.
Gene_expression (products) of platelet-activating factor in platelet associated with qutenza
10) Confidence 0.22 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7714786 Disease Relevance 0 Pain Relevance 1.15
This study aimed to determine whether platelet-activating factor or products of cyclo-oxygenase metabolism (thromboxane A2 or prostaglandins) were important in mediating the response of platelets to endotoxin.
Gene_expression (products) of platelet-activating factor in platelets
11) Confidence 0.19 Published 1996 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8735817 Disease Relevance 0.08 Pain Relevance 0.15
An inhibition of platelet-activating factor synthesis may contribute to the antiinflammatory, analgesic, or antipyretic actions of these compounds.
Gene_expression (synthesis) of platelet-activating factor in platelet associated with inflammation and analgesic
12) Confidence 0.18 Published 1988 Journal Prostaglandins Section Abstract Doc Link 2903520 Disease Relevance 0.19 Pain Relevance 0.18
When endothelial cells are subjected to hypoxia, there is stimulation of the cells which shows itself as increased synthesis of prostaglandins and of PAF (Platelet Activating Factor).
Gene_expression (synthesis) of Platelet Activating Factor in Platelet associated with hypoxia
13) Confidence 0.17 Published 1992 Journal Phlebologie Section Abstract Doc Link 1496030 Disease Relevance 0.48 Pain Relevance 0.19
New drugs which inhibit the synthesis of leukotrienes and platelet activating factor may be useful therapeutic agents.
Gene_expression (synthesis) of platelet activating factor in platelet
14) Confidence 0.06 Published 1989 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 2691152 Disease Relevance 0.32 Pain Relevance 0.30
However, smoking impairs the therapeutic effects of histamine-2 antagonists, may stimulate pepsin secretion, promotes reflux of duodenal contents into the stomach, increases the risk for and harmful effects of H. pylori, and increases production of free radicals, vasopressin, secretion by the pituitary, secretion of endothelin by the gastric mucosa, and production of platelet activating factor.
Gene_expression (production) of platelet activating factor in platelet associated with nicotine addiction and antagonist
15) Confidence 0.04 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479620 Disease Relevance 1.81 Pain Relevance 0.40
In IBD, there is increased synthesis and release of pro-inflammatory mediators, such as eicosanoids, platelet activating factor, reactive oxygen species (ROS), nitrogen metabolites, chemokines and mainly cytokines [5] that have been associated with disease severity, activity and remission [2].
Gene_expression (synthesis) of platelet activating factor in platelet associated with chemokine, inflammatory bowel disease, inflammatory mediators, disease and cytokine
16) Confidence 0.03 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2909993 Disease Relevance 1.75 Pain Relevance 0.38
It is also characteristic of Nimesulide its antioxidant activity and suppression of: the synthesis of superoxidic ions from the neutrophils; also, the synthesis of platelet activating factor.
Gene_expression (synthesis) of platelet activating factor in platelet
17) Confidence 0.02 Published 2000 Journal Vutr Boles Section Abstract Doc Link 11195195 Disease Relevance 0.42 Pain Relevance 0.37
Phospholipase A2 (PLA2) regulates eicosanoid and platelet-activating factor production.
Gene_expression (production) of platelet-activating factor in platelet
18) Confidence 0.01 Published 1999 Journal Shock Section Abstract Doc Link 10588517 Disease Relevance 0.44 Pain Relevance 0.16
Glucocorticosteroids (GCS) are considered potent inhibitors of the synthesis of all arachidonic acid-derived mediators, including the LTs and platelet-activating factor, and decrease the synthesis of inflammatory prostanoids (Devillier et al 1999b).
Gene_expression (synthesis) of platelet-activating factor in platelet associated with inflammation
19) Confidence 0.00 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 0.88 Pain Relevance 0.27

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