INT105111

Context Info Confidence 0.03 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.53 Pain Relevance 0.54

cytoplasm (Plat, NFKB1) nucleoplasm (NFKB1) mitochondrion (NFKB1) cytosol (NFKB1) signal transduction (NFKB1) extracellular space (Plat)

Anatomy Link Frequency HL-60 2 Plat (Mus musculus) NFKB1 (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 7 99.98 Inflammation 1 83.56

Disease Link Frequency Relevance Heat Cancer 2 96.60 Leukemia 2 94.88 Nociception 1 84.40 INFLAMMATION 1 83.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kappaB through inhibition of IkappaB alpha degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells.

Negative_regulation (suppresses) of TPA Positive_regulation (activation) of NF-kappaB in HL-60 associated with leukemia and qutenza

1) Confidence 0.03 Published 2002 Journal Arch. Pharm. Res. Section Abstract Doc Link 12214859 Disease Relevance 0.53 Pain Relevance 0.54

General Comments

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