INT105112

Context Info Confidence 0.01 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 3 Disease Relevance 1.55 Pain Relevance 1.58

nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) DNA binding (JUN) cytoplasm (Plat) cytosol (JUN)

Anatomy Link Frequency skin 2 Plat (Mus musculus) JUN (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 21 99.28 Inflammation 3 93.04

Disease Link Frequency Relevance Heat Cancer 6 100.00 Leukemia 6 94.48 Nociception 3 93.88 INFLAMMATION 3 93.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Likewise, TPA-induced activation of AP-1 was mitigated by capsaicin treatment.

TPA Positive_regulation (activation) of AP-1 associated with qutenza

1) Confidence 0.01 Published 2002 Journal Arch. Pharm. Res. Section Abstract Doc Link 12214859 Disease Relevance 0.48 Pain Relevance 0.53

Previous studies from this laboratory revealed that capsaicin, when topically applied onto dorsal skin of female ICR mice, strongly attenuated activation of NF-kappaB and AP-1 induced by the typical tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), which may account for its anti-tumor promoting activity in mouse skin.

TPA Positive_regulation (induced) of AP-1 in skin associated with qutenza and cancer

2) Confidence 0.01 Published 2002 Journal Arch. Pharm. Res. Section Abstract Doc Link 12214859 Disease Relevance 0.53 Pain Relevance 0.52

Previous studies from this laboratory revealed that capsaicin, when topically applied onto dorsal skin of female ICR mice, strongly attenuated activation of NF-kappaB and AP-1 induced by the typical tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), which may account for its anti-tumor promoting activity in mouse skin.

TPA Positive_regulation (activation) of AP-1 in skin associated with qutenza and cancer

3) Confidence 0.01 Published 2002 Journal Arch. Pharm. Res. Section Abstract Doc Link 12214859 Disease Relevance 0.54 Pain Relevance 0.53

General Comments

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