INT105113

Context Info Confidence 0.03 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.06 Pain Relevance 1.06

cytoplasm (Plat, NFKB1) nucleoplasm (NFKB1) mitochondrion (NFKB1) cytosol (NFKB1) signal transduction (NFKB1) extracellular space (Plat)

Anatomy Link Frequency HL-60 1 skin 1 Plat (Mus musculus) NFKB1 (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 14 99.76 Inflammation 2 93.04

Disease Link Frequency Relevance Heat Cancer 4 100.00 Leukemia 4 94.88 Nociception 2 93.88 INFLAMMATION 2 93.04

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Anatomy

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Previous studies from this laboratory revealed that capsaicin, when topically applied onto dorsal skin of female ICR mice, strongly attenuated activation of NF-kappaB and AP-1 induced by the typical tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), which may account for its anti-tumor promoting activity in mouse skin.

TPA Positive_regulation (activation) of NF-kappaB in skin associated with qutenza and cancer

1) Confidence 0.03 Published 2002 Journal Arch. Pharm. Res. Section Abstract Doc Link 12214859 Disease Relevance 0.54 Pain Relevance 0.53

In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kappaB through inhibition of IkappaB alpha degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells.

TPA Positive_regulation (activation) of NF-kappaB in HL-60 associated with leukemia and qutenza

2) Confidence 0.03 Published 2002 Journal Arch. Pharm. Res. Section Abstract Doc Link 12214859 Disease Relevance 0.53 Pain Relevance 0.54

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