INT105150

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PTBP1) mRNA processing (PTBP1) nucleolus (PTBP1)
RNA binding (PTBP1) nucleus (PTBP1)
Anatomy Link Frequency
Acb 1
PTBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nucleus accumbens 8 96.60 Very High Very High Very High
opioid receptor 1 93.32 High High
projection neuron 1 70.00 Quite High
Enkephalin 2 25.00 Low Low
tolerance 13 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 79 99.52 Very High Very High Very High
Insulin Resistance 35 50.00 Quite Low
Disease 17 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 13 5.00 Very Low Very Low Very Low
Obesity 7 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Hyperinsulinism 2 5.00 Very Low Very Low Very Low
Metabolic Disorder 2 5.00 Very Low Very Low Very Low
Hypertrophy 1 5.00 Very Low Very Low Very Low
Subacute Sclerosing Panencephalitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, our new analysis procedure subsequently identified CDC42 and PTBP1 as being equally targeted by both up- and down-regulated miRNAs (Additional file 2); thus, CDC42 and PTBP1 should not be altered in vivo by diabetes (as we demonstrated by western blotting prior to developing our ranking metric).


Neg (not) Regulation (altered) of PTBP1 associated with diabetes mellitus
1) Confidence 0.39 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.28 Pain Relevance 0
Double-immunofluorescence analysis revealed that PPD, PPE and PPTB immunoreactivities were shown in 69%, 19% and 14% of PPTA-immunoreactive neurons, respectively, in the Acb core region, and in 92%, 7% and 25% of PPTA-immunoreactive neurons, respectively, in the Acb shell region.
Regulation (immunoreactivities) of PPTB in Acb associated with nucleus accumbens
2) Confidence 0.26 Published 2002 Journal Neuroscience Section Abstract Doc Link 12220564 Disease Relevance 0 Pain Relevance 0.38

General Comments

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