INT105154

Context Info Confidence 0.41 First Reported 2002 Last Reported 2004 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.33 Pain Relevance 0.83

nucleus (BHLHE22)

Anatomy Link Frequency nerves 2 BHLHE22 (Homo sapiens)

Pain Link Frequency Relevance Heat nav1.8 2 98.60 addiction 1 98.36 nav1.3 2 91.20 Analgesic 1 87.44 Pain 1 76.08 sodium channel 6 75.00 Neuropathic pain 1 55.60

Disease Link Frequency Relevance Heat Injury 2 98.04 Pain 1 76.08 Nociception 1 74.48 Neuropathic Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Coexpression of beta1 or beta3 did not affect inactivation time course or the voltage dependence of activation, but shifted the inactivation curve approximately 10 mV negative, and slowed the repriming rate ca. three-fold. beta2 did not affect channel properties, either by itself or in combination with beta1 or beta3.

Neg (not) Regulation (affect) of Gene_expression (Coexpression) of beta3 associated with addiction

1) Confidence 0.41 Published 2002 Journal Neuroscience Section Abstract Doc Link 12220575 Disease Relevance 0.07 Pain Relevance 0.31

Unlike beta1- and beta2, beta3-immunoreactivity did not decrease after avulsion injury, and the beta3:neurofilament ratio was significantly increased in proximal injured human nerves. beta3-subunit expression may thus be regulated differently from beta1, beta2 and Nav1.8.

Regulation (regulated) of Gene_expression (expression) of beta3 in nerves associated with injury and nav1.8

2) Confidence 0.17 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232296 Disease Relevance 0.26 Pain Relevance 0.52

General Comments

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