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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (BHLHE22)
Anatomy Link Frequency
nerves 2
BHLHE22 (Homo sapiens)
Pain Link Frequency Relevance Heat
nav1.8 2 98.60 Very High Very High Very High
addiction 1 98.36 Very High Very High Very High
nav1.3 2 91.20 High High
Analgesic 1 87.44 High High
Pain 1 76.08 Quite High
sodium channel 6 75.00 Quite High
Neuropathic pain 1 55.60 Quite High
Disease Link Frequency Relevance Heat
Injury 2 98.04 Very High Very High Very High
Pain 1 76.08 Quite High
Nociception 1 74.48 Quite High
Neuropathic Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coexpression of beta1 or beta3 did not affect inactivation time course or the voltage dependence of activation, but shifted the inactivation curve approximately 10 mV negative, and slowed the repriming rate ca. three-fold. beta2 did not affect channel properties, either by itself or in combination with beta1 or beta3.
Neg (not) Regulation (affect) of Gene_expression (Coexpression) of beta3 associated with addiction
1) Confidence 0.41 Published 2002 Journal Neuroscience Section Abstract Doc Link 12220575 Disease Relevance 0.07 Pain Relevance 0.31
Unlike beta1- and beta2, beta3-immunoreactivity did not decrease after avulsion injury, and the beta3:neurofilament ratio was significantly increased in proximal injured human nerves. beta3-subunit expression may thus be regulated differently from beta1, beta2 and Nav1.8.
Regulation (regulated) of Gene_expression (expression) of beta3 in nerves associated with injury and nav1.8
2) Confidence 0.17 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232296 Disease Relevance 0.26 Pain Relevance 0.52

General Comments

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