INT105156

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Context Info
Confidence 0.79
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 11.85
Pain Relevance 13.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
masseter 5
microglia 3
neuronal 3
Spinal cord 2
astrocyte 2
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 140 99.98 Very High Very High Very High
Glutamate 117 99.66 Very High Very High Very High
Inflammation 601 99.64 Very High Very High Very High
cerebral cortex 5 99.48 Very High Very High Very High
Spinal cord 48 99.44 Very High Very High Very High
intrathecal 50 98.60 Very High Very High Very High
allodynia 191 98.32 Very High Very High Very High
ketamine 94 98.12 Very High Very High Very High
agonist 35 98.00 Very High Very High Very High
Hippocampus 5 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dermatitis 16 99.64 Very High Very High Very High
Propionic Acidemia 1 99.56 Very High Very High Very High
Injury 208 99.44 Very High Very High Very High
INFLAMMATION 667 99.30 Very High Very High Very High
Neuropathic Pain 290 98.32 Very High Very High Very High
Nociception 99 97.52 Very High Very High Very High
Hyperalgesia 786 94.20 High High
Pain 366 93.24 High High
Cretinism 4 86.76 High High
Intellectual Impairment 2 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glutamate and NMDA also stimulated GFAP phosphorylation in mixed neuronal/glial cell cultures from the cerebellum, although no effect of these agonists was observed in primary cultures of cerebellar astrocytes.
Phosphorylation (phosphorylation) of GFAP in glial cell associated with glutamate and agonist
1) Confidence 0.79 Published 2002 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 12220706 Disease Relevance 0 Pain Relevance 0.54
Thus, in cerebellar microslices, NMDA consistently stimulated GFAP phosphorylation, whereas no effect of metabotropic or non-NMDA ionotropic agonists was observed.
Phosphorylation (phosphorylation) of GFAP associated with agonist
2) Confidence 0.79 Published 2002 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 12220706 Disease Relevance 0 Pain Relevance 0.48
In previous work we showed that phosphorylation of glial fibrillary acidic protein (GFAP), an astrocyte marker, is increased by glutamate in hippocampal slices from immature rats via a type II metabotropic receptor.
Phosphorylation (phosphorylation) of GFAP in astrocyte associated with glutamate
3) Confidence 0.79 Published 2002 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 12220706 Disease Relevance 0 Pain Relevance 0.27
In the present work we show that glutamate also stimulates GFAP phosphorylation in microslices prepared from immature cerebellar cortex, but by a different receptor mechanism from that observed in the hippocampus.
Phosphorylation (phosphorylation) of GFAP in hippocampus associated with glutamate and hippocampus
4) Confidence 0.79 Published 2002 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 12220706 Disease Relevance 0 Pain Relevance 0.38
This treatment induced hyperphosphorylation of neurofilaments, the neuronal intermediate filament (IF) proteins, of heavy, medium and low molecular weight (NF-H, NF-M and NF-L, respectively) without altering the phosphorylation level of astrocyte IF proteins, glial fibrillary acidic protein (GFAP) and vimentin in cerebral cortex of rats.
Phosphorylation (phosphorylation) of GFAP in neuronal associated with cerebral cortex
5) Confidence 0.73 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.30 Pain Relevance 0.16
This treatment induced hyperphosphorylation of neurofilaments, the neuronal intermediate filament (IF) proteins, of heavy, medium and low molecular weight (NF-H, NF-M and NF-L, respectively) without altering the phosphorylation level of astrocyte IF proteins, glial fibrillary acidic protein (GFAP) and vimentin in cerebral cortex of rats.
Phosphorylation (phosphorylation) of glial fibrillary acidic protein in neuronal associated with cerebral cortex
6) Confidence 0.73 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.30 Pain Relevance 0.16
For fluorescence staining (phosphorylation at serine 896 of the NR1 subunit, P-NR1; GFAP, glial fibrillary acidic protein; CD11b, cluster of differentiation 11b; NeuN), the sections were incubated with Streptavidin-Alexa Fluor 568 or 488 (1:600, Molecular Probes, Eugene, OR) for 1 h.
Phosphorylation (phosphorylation) of GFAP
7) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.10 Pain Relevance 0.22
To verify differential involvement of the trigeminal Vi/Vc transition zone and caudal laminated Vc in response to deep or cutaneous orofacial tissue injury, we examined NMDA receptor phosphorylation and upregulation of GFAP, a marker of reactive astrocytes after masseter and cutaneous inflammation.
Spec (examined) Phosphorylation (phosphorylation) of GFAP in masseter associated with inflammation, nmda receptor and injury
8) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.91 Pain Relevance 0.66
Effects of masseter and skin inflammation on NMDA receptor phosphorylation and GFAP protein levels
Phosphorylation (phosphorylation) of GFAP in skin associated with inflammation, nmda receptor and dermatitis
9) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.72 Pain Relevance 0.51
Western blot data showed that masseter inflammation induced an enhanced NMDA receptor phosphorylation and upregulation of GFAP in both Vi/Vc and Vc zones, while cutaneous inflammation only induced similar effects in the caudal Vc.
Phosphorylation (phosphorylation) of GFAP in masseter associated with inflammation and nmda receptor
10) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.37 Pain Relevance 1.11
In the same region, persistent upregulation of NMDA receptor NR1 phosphorylation and protein expression and increased expression of glial markers glial fibrillary acidic protein (astroglia) and CD11b (microglia) were found.
Phosphorylation (phosphorylation) of glial fibrillary acidic protein in microglia
11) Confidence 0.52 Published 2010 Journal Mol Pain Section Body Doc Link 20633279 Disease Relevance 0.16 Pain Relevance 0
For fluorescence staining (phosphorylation at serine 896 of the NR1 subunit, P-NR1; GFAP, glial fibrillary acidic protein; CD11b, cluster of differentiation 11b; NeuN), the sections were incubated with Streptavidin-Alexa Fluor 568 or 488 (1:600, Molecular Probes, Eugene, OR) for 1 h.
Phosphorylation (phosphorylation) of glial fibrillary acidic protein
12) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.10 Pain Relevance 0.22
NMDA receptor expression and phosphorylation were upregulated, as well as GFAP and CD11b, markers of astroglia and microglia, respectively.
Phosphorylation (phosphorylation) of GFAP in microglia associated with nmda receptor
13) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.90 Pain Relevance 1.31
Spinal cord sections from the AM281 + AM630/PPF group demonstrated significantly lower GFAP and pospho-p38 staining compared to sections from AM281 + AM630/Saline animals, indicating that propentofylline treatment had reversed the persistent increase in spinal GFAP expression and p38 phosphorylation induced by the dual CB1/CB2 receptor blockade (Figure 8).


Phosphorylation (phosphorylation) of GFAP in Spinal cord associated with spinal cord
14) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.38 Pain Relevance 0.49
These animals were used to provide spinal cord tissue for the analysis of GFAP expression and p38 phosphorylation.
Phosphorylation (phosphorylation) of GFAP in spinal cord associated with spinal cord
15) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0 Pain Relevance 0.30
In contrast, injection of CFA into the cutaneous site only produced an increase in NMDA receptor phosphorylation (Fig. 8A right) and GFAP (Fig. 8B right) levels in the Vc without an effect in Vi/Vc.


Phosphorylation (phosphorylation) of GFAP associated with nmda receptor
16) Confidence 0.47 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.08 Pain Relevance 0.84
These observations are further supported by Western blot analysis that shows a selective enhancement of NMDA receptor phosphorylation and GFAP upregulation in the Vi/Vc transition zone after masseter inflammation.
Phosphorylation (phosphorylation) of GFAP in masseter associated with inflammation and nmda receptor
17) Confidence 0.47 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.00 Pain Relevance 0.74
We have shown that masseter inflammation induced a significant increase in NMDA receptor NR1 subunit phosphorylation and GFAP levels in the Vi/Vc transition zone [17].
Phosphorylation (phosphorylation) of GFAP in masseter associated with inflammation and nmda receptor
18) Confidence 0.47 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.94 Pain Relevance 0.72
Injection of CFA into the masseter produced significant increases in N-methyl-D-aspartate (NMDA) receptor NR1 serine 896 phosphorylation and glial fibrillary acidic protein (GFAP) levels, a marker of reactive astrocytes, in Vi/Vc and caudal Vc.
Phosphorylation (phosphorylation) of GFAP in astrocytes
19) Confidence 0.47 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2806354 Disease Relevance 1.11 Pain Relevance 0.90
In the same region, persistent upregulation of NMDA receptor NR1 phosphorylation and protein expression and increased expression of glial markers glial fibrillary acidic protein (astroglia) and CD11b (microglia) were found.
Phosphorylation (phosphorylation) of glial fibrillary acidic protein in microglia associated with nmda receptor
20) Confidence 0.42 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2914030 Disease Relevance 0.94 Pain Relevance 0.86

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