INT105256

Context Info Confidence 0.68 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 13 Disease Relevance 10.09 Pain Relevance 4.83

plasma membrane (F2rl1) signal transducer activity (F2rl1)

Anatomy Link Frequency colon 8 mast cell 6 paw 2 dorsal root ganglia 2 F2rl1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat nMDA receptor 36 99.82 Neuropeptide 4 99.76 Inflammation 162 99.66 substance P 5 98.72 spastic colon 206 98.48 antagonist 51 97.40 qutenza 11 97.40 agonist 20 96.16 nud 114 88.48 headache 23 85.00

Disease Link Frequency Relevance Heat Stress 369 99.98 INFLAMMATION 142 99.66 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 228 98.48 Pressure And Volume Under Development 2 93.64 Dyspepsia 114 88.48 Headache 77 85.00 Infection 64 81.04 Neuropathic Pain 20 76.88 Hypersensitivity 28 76.00 Pain 42 75.68

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results of the present study confirmed that PAR2 expression was significantly increased by stress.

Positive_regulation (increased) of Gene_expression (expression) of PAR2 associated with stress

1) Confidence 0.68 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.94 Pain Relevance 0.60

Acute stress in rats increases mast cell numbers and mucosal PAR2 expression in the colon.

Positive_regulation (increases) of Gene_expression (expression) of PAR2 in mast cell associated with stress

2) Confidence 0.68 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2923781 Disease Relevance 0.29 Pain Relevance 0

Stress-induced Alterations in Mast Cell Numbers and Proteinase-activated Receptor-2 Expression of the Colon: Role of Corticotrophin-releasing Factor This study was performed in order to assess whether acute stress can increase mast cell and enterochromaffin (EC) cell numbers, and proteinase-activated receptor-2 (PAR2) expression in the rat colon.

Positive_regulation (increase) of Gene_expression (expression) of PAR2 in colon associated with stress

3) Confidence 0.68 Published 2010 Journal Journal of Korean Medical Science Section Title Doc Link PMC2923781 Disease Relevance 0.35 Pain Relevance 0

In conclusion, acute stress in rats increases mast cell numbers and mucosal PAR2 expression in the colon.

Positive_regulation (increases) of Gene_expression (expression) of PAR2 in colon associated with stress

4) Confidence 0.68 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 1.11 Pain Relevance 0.70

Thus, it is plausible that CRF released during acute stress increases mast cell numbers and degranulates mast cells, which upregulates PAR2 expression in the colon.

Positive_regulation (upregulates) of Gene_expression (expression) of PAR2 in colon associated with stress

5) Confidence 0.49 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.99 Pain Relevance 0.56

Stress-induced Alterations in Mast Cell Numbers and Proteinase-activated Receptor-2 Expression of the Colon: Role of Corticotrophin-releasing Factor This study was performed in order to assess whether acute stress can increase mast cell and enterochromaffin (EC) cell numbers, and proteinase-activated receptor-2 (PAR2) expression in the rat colon.

Positive_regulation (increase) of Gene_expression (expression) of proteinase-activated receptor-2 in colon associated with stress

6) Confidence 0.49 Published 2010 Journal Journal of Korean Medical Science Section Title Doc Link PMC2923781 Disease Relevance 0.35 Pain Relevance 0

We speculate that a 90 min restraint session permits the release of CRF, which is able to increase mast cells and PAR2 expression in the colon.

Positive_regulation (increase) of Gene_expression (expression) of PAR2 in mast cells

7) Confidence 0.46 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 1.16 Pain Relevance 0.79

Our results of the present study showed that acute immobilization stress increased mast cell numbers and PAR2 expression in the colon and these stress effects were inhibited by the CRF antagonist astressin.

Positive_regulation (increased) of Gene_expression (expression) of PAR2 in mast cell associated with stress and antagonist

8) Confidence 0.46 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.58 Pain Relevance 0.22

Immunohistochemical analyses using the polyclonal antibody against rat PAR-2 clearly showed abundant expression of PAR-2 in rat pancreatic and parotid acini.

Positive_regulation (abundant) of Gene_expression (expression) of PAR-2

9) Confidence 0.43 Published 2002 Journal Life Sci. Section Abstract Doc Link 12231404 Disease Relevance 0 Pain Relevance 0.08

CONCLUSIONS: These studies demonstrate that 1) CYP induced cystitis up-regulates PAR2 to 4 expression in the bladder, 2) PAR2 to 4 is expressed in urothelium, detrusor muscle and bladder nerve fibers in control and CYP treated rats, and 3) bladder C-fibers and bladder afferent cells in dorsal root ganglia express PAR2 to 4.

Positive_regulation (up-regulates) of Gene_expression (expression) of PAR2 in dorsal root ganglia

10) Confidence 0.42 Published 2005 Journal J. Urol. Section Body Doc Link 15643279 Disease Relevance 0.11 Pain Relevance 0

Furthermore, inflammation resulted in the activation of the PAR2 receptors expressed on CANs.

Positive_regulation (activation) of Gene_expression (expressed) of PAR2 associated with inflammation

11) Confidence 0.39 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2758842 Disease Relevance 0.94 Pain Relevance 0.60

Our data show that inflammation causes an up-regulation of the NMDA receptor and the activation of the PAR2 receptor expressed on CANs.

Positive_regulation (activation) of Gene_expression (expressed) of PAR2 associated with inflammation and nmda receptor

12) Confidence 0.39 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2758842 Disease Relevance 0.87 Pain Relevance 0.57

The activation of PAR-2 provokes Ca++ mobilization and CGRP and substance P release in slices of rat isolated neurons or vascular intracranial structures cultured in vitro, while in vivo the swelling CGRP-induced of the rat paw is observed.

Positive_regulation (activation) of Gene_expression (provokes) of PAR-2 in paw associated with pressure and volume under development and substance p

13) Confidence 0.04 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2771268 Disease Relevance 0.66 Pain Relevance 0.72

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