INT105287

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 24
Total Number 27
Disease Relevance 15.41
Pain Relevance 6.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slco1c1)
Anatomy Link Frequency
brain 8
cerebral hemisphere 1
endothelial cells 1
nerve 1
thoracic 1
Slco1c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 104 99.84 Very High Very High Very High
IPN 17 99.52 Very High Very High Very High
Spinal cord 116 99.44 Very High Very High Very High
Central nervous system 277 99.38 Very High Very High Very High
Inflammation 25 98.88 Very High Very High Very High
Pain 20 98.88 Very High Very High Very High
c fibre 168 98.66 Very High Very High Very High
qutenza 52 98.42 Very High Very High Very High
Inflammatory mediators 3 98.32 Very High Very High Very High
spinal dorsal horn 8 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sepsis 368 99.98 Very High Very High Very High
Nervous System Injury 236 99.84 Very High Very High Very High
Injury 180 99.52 Very High Very High Very High
Inflammatory Pain 17 99.52 Very High Very High Very High
Pressure And Volume Under Development 308 99.28 Very High Very High Very High
INFLAMMATION 10 98.32 Very High Very High Very High
Brain Injury 96 97.96 Very High Very High Very High
Cv Unclassified Under Development 11 96.96 Very High Very High Very High
Stress 14 96.60 Very High Very High Very High
Hypoxia 15 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To our knowledge, the present data are the first to show the positive effects of magnesium on sepsis-induced BBB permeability changes.
Positive_regulation (induced) of BBB associated with sepsis
1) Confidence 0.34 Published 2005 Journal Crit Care Section Body Doc Link PMC1065104 Disease Relevance 0.82 Pain Relevance 0
This increase in BBB to protein tracers was most pronounced on the 2nd day of morphine withdrawal.
Positive_regulation (increase) of BBB associated with withdrawal and morphine
2) Confidence 0.33 Published 2010 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 19812922 Disease Relevance 0.83 Pain Relevance 0.86
Magnesium administration attenuated the increased BBB permeability defect and caused a reduction in brain edema formation in our rat model of intraperitoneal sepsis.



Positive_regulation (increased) of BBB in brain associated with pressure and volume under development and sepsis
3) Confidence 0.32 Published 2005 Journal Crit Care Section Abstract Doc Link PMC1065104 Disease Relevance 0.51 Pain Relevance 0
Although this might have clinical significance, a contrary suggestion could be that increasing the integrity of the BBB might also have negative effects in terms of antibiotic emergence when the clinical situation is complicated with encephalitis or meningitis.
Positive_regulation (increasing) of BBB associated with meningitis and viral meningitis
4) Confidence 0.32 Published 2005 Journal Crit Care Section Body Doc Link PMC1065104 Disease Relevance 0.79 Pain Relevance 0
Sepsis significantly increased BBB permeability to Evans blue.
Positive_regulation (increased) of BBB associated with sepsis
5) Confidence 0.32 Published 2005 Journal Crit Care Section Abstract Doc Link PMC1065104 Disease Relevance 0.47 Pain Relevance 0
A major finding of the present study is that magnesium administration attenuates the increase in BBB permeability and edema formation.
Positive_regulation (increase) of BBB associated with pressure and volume under development
6) Confidence 0.32 Published 2005 Journal Crit Care Section Body Doc Link PMC1065104 Disease Relevance 1.52 Pain Relevance 0
Magnesium administration attenuated the increased BBB permeability and caused a reduction in brain edema formation in our rat model of intraperitoneal sepsis.
Positive_regulation (increased) of BBB in brain associated with pressure and volume under development and sepsis
7) Confidence 0.32 Published 2005 Journal Crit Care Section Body Doc Link PMC1065104 Disease Relevance 1.08 Pain Relevance 0
Quantitative estimation of the EB dye revealed that sepsis significantly increased BBB permeability as measured by EB extravasations into brain tissue.
Positive_regulation (increased) of BBB in brain associated with sepsis
8) Confidence 0.32 Published 2005 Journal Crit Care Section Body Doc Link PMC1065104 Disease Relevance 0.70 Pain Relevance 0
This investigation shows that sepsis increases BBB permeability and leads to the formation of brain edema in septic rats.
Positive_regulation (increases) of BBB in brain associated with pressure and volume under development and sepsis
9) Confidence 0.32 Published 2005 Journal Crit Care Section Body Doc Link PMC1065104 Disease Relevance 1.10 Pain Relevance 0
Biphasic cytoarchitecture and functional changes in the BBB induced by chronic inflammatory pain.
Positive_regulation (induced) of BBB associated with inflammation and ipn
10) Confidence 0.07 Published 2006 Journal Brain Res. Section Title Doc Link 17007822 Disease Relevance 0.91 Pain Relevance 1.06
The permeability of the BBB was significantly increased at 24 and 72 h post-CFA.
Positive_regulation (increased) of BBB
11) Confidence 0.07 Published 2006 Journal Brain Res. Section Abstract Doc Link 17007822 Disease Relevance 0.99 Pain Relevance 0.69
Another possible explanation would be that Na+ ions enter the cerebral parenchyma via increased BBB permeability caused by BBB breakdown.
Positive_regulation (increased) of BBB in parenchyma
12) Confidence 0.06 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3004923 Disease Relevance 0.37 Pain Relevance 0
The reason that mannitol accumulates in the non-ischemic brain tissue may be related to increase of BBB permeability resulting from a variety of inflammatory mediators induced by ischemia, hypoxia and oxidative stress [42,43] and opening of BBB by itself [44].
Positive_regulation (increase) of BBB in brain associated with stress, inflammatory mediators, hypoxia and ischemia
13) Confidence 0.06 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3004923 Disease Relevance 0.69 Pain Relevance 0.10
The authors proposed that hypertonic solutions increased BBB permeability by inducing the shrinkage of cerebrovascular endothelial cells, thus producing a disruption of inter-endothelial tight junctions (31,32).
Positive_regulation (increased) of BBB in endothelial cells
14) Confidence 0.06 Published 2008 Journal AAPS J Section Body Doc Link PMC2751463 Disease Relevance 0 Pain Relevance 0.20
The dynamics in the exposure of the brain to Gd-DTPA over time highlighted two different mechanisms by which the procedure increases BBB permeability: (1) a direct permeabilization of the BBB, (2) and a diffusion of the contrast agent within the brain from the area described above (Fig. 5).
Positive_regulation (increases) of BBB in brain
15) Confidence 0.06 Published 2008 Journal AAPS J Section Body Doc Link PMC2751463 Disease Relevance 0 Pain Relevance 0.11
Using different tools, amongst which MRI as a real-time in vivo characterization of the BBB permeability and CNS delivery, we attempt to better define the osmotic BBB permeabilization physiology.
Positive_regulation (permeabilization) of BBB
16) Confidence 0.04 Published 2008 Journal AAPS J Section Abstract Doc Link PMC2751463 Disease Relevance 0 Pain Relevance 0
The dynamics in the exposure of the brain to Gd-DTPA over time highlighted two different mechanisms by which the procedure increases BBB permeability: (1) a direct permeabilization of the BBB, (2) and a diffusion of the contrast agent within the brain from the area described above (Fig. 5).
Positive_regulation (permeabilization) of BBB in brain
17) Confidence 0.04 Published 2008 Journal AAPS J Section Body Doc Link PMC2751463 Disease Relevance 0 Pain Relevance 0.09
Undoubtedly, abnormal accumulation of 20% mannitol in the pre-ischemic cerebral hemisphere and the non-ischemic cerebral hemisphere offset an osmotic pressure gradient inside and outside the BBB induced by mannitol.
Positive_regulation (induced) of BBB in cerebral hemisphere
18) Confidence 0.04 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3004923 Disease Relevance 0.68 Pain Relevance 0.12
Thus, CNS injury cannot account for the increases in BSCB and BBB permeability we have found presently.
Positive_regulation (increases) of BBB associated with injury and central nervous system
19) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0.95 Pain Relevance 0.43
Taking our findings together, the most parsimonious explanation is that discharge activity in TRPV1-expressing C-fibers triggers a cascade of events which, after many hours, leads to an increase in BSCB and BBB permeability.
Positive_regulation (increase) of BBB associated with c fibre
20) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0.33 Pain Relevance 1.03

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