INT105289

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Context Info
Confidence 0.76
First Reported 2002
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 28
Total Number 32
Disease Relevance 11.72
Pain Relevance 4.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1)
cytoplasm (Tjp1)
Anatomy Link Frequency
brain 5
epithelium 4
ileum 3
intestine 2
blood 1
Tjp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 516 99.68 Very High Very High Very High
Inflammation 49 97.88 Very High Very High Very High
Neuropathic pain 1 94.44 High High
anesthesia 25 94.40 High High
Central nervous system 11 92.08 High High
IPN 17 91.20 High High
Hyperalgesia 2 88.04 High High
cytokine 44 86.00 High High
withdrawal 2 84.96 Quite High
halothane 1 79.40 Quite High
Disease Link Frequency Relevance Heat
Reperfusion Injury 378 99.76 Very High Very High Very High
Cv Unclassified Under Development 438 99.68 Very High Very High Very High
Cv General 4 Under Development 76 98.64 Very High Very High Very High
Sprains And Strains 18 98.14 Very High Very High Very High
Inflammatory Bowel Disease 18 97.88 Very High Very High Very High
Obesity 32 96.36 Very High Very High Very High
Injury 26 94.80 High High
Neuropathic Pain 1 94.44 High High
Inflammatory Pain 17 91.20 High High
Hyperalgesia 2 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ZO-1 expression was significantly increased at 1, 3, and 6 h and returned to control expression levels by 12 h.
Gene_expression (expression) of ZO-1
1) Confidence 0.76 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12234806 Disease Relevance 0.30 Pain Relevance 0.29
Furthermore, changes in BBB function are correlated with altered tight junctional protein expression of occludin and ZO-1.
Gene_expression (expression) of ZO-1
2) Confidence 0.76 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12234806 Disease Relevance 0.22 Pain Relevance 0.24
It analyzes the expressions of occludin, ZO-1, and connexin 43 by immunoconfocal microscopy.
Spec (analyzes) Gene_expression (expressions) of ZO-1
3) Confidence 0.74 Published 2005 Journal Int. J. Neurosci. Section Abstract Doc Link 16162451 Disease Relevance 0.37 Pain Relevance 0.13
Western blot revealed that ASA inhibited ZO-1 expression and LaLB with its spent culture supernatant counteracted this effect.
Gene_expression (expression) of ZO-1
4) Confidence 0.70 Published 2004 Journal Digestion Section Body Doc Link 15205571 Disease Relevance 0 Pain Relevance 0
The morphology/polarity score significantly correlated with ZO-1 (Pearson r = 0.3935, p = 0.0423) and chondroitin sulfate (Pearson r = 0.7079, p <0.0001) expression.
Gene_expression (expression) of ZO-1
5) Confidence 0.41 Published 2004 Journal J. Urol. Section Body Doc Link 15017219 Disease Relevance 0 Pain Relevance 0
Western blot analysis with brain tissue homogenates show that the protein levels of the tight junction proteins ZO-1 and occludin in the ultrasound treated region is not changed compared to non-treated regions (Figure 3A).
Gene_expression (levels) of ZO-1 in brain
6) Confidence 0.40 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
Here we show that the protein levels of occludin and ZO-1 are not altered, but instead their interaction is considerably reduced in the sonicated brain areas, suggesting that the decrease in immunogold signals may be the consequence of the redistribution of tight junction proteins.
Gene_expression (levels) of ZO-1 in brain
7) Confidence 0.40 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
In patients vs controls findings were abnormal for uroplakin in 13 of 27 vs 1 of 7 (p = 0.085), for E-cadherin (over expressed) in 18 of 27 vs 0 of 7 (p = 0.0021), for ZO-1 in 11 of 27 vs 0 of 7 (p = 0.046) and for chondroitin sulfate in 15 of 27 vs 0 of 7 (p = 0.0054).
Spec (findings) Gene_expression (abnormal) of ZO-1
8) Confidence 0.36 Published 2004 Journal J. Urol. Section Body Doc Link 15017219 Disease Relevance 0 Pain Relevance 0
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Gene_expression (i.e.) of ZO-1 in brain
9) Confidence 0.34 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.14 Pain Relevance 0.14
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Gene_expression (expression) of ZO-1 in brain
10) Confidence 0.34 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.14 Pain Relevance 0.14
Brain permeability to (14)C-sucrose was increased and expression of TJ proteins (i.e., claudin-5, occludin, zonula occluden (ZO-1)) were also altered after 3 h CIP.
Gene_expression (expression) of ZO-1 in Brain
11) Confidence 0.30 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.15 Pain Relevance 0.15
Immunohistochemistry using control sections of rat ileum demonstrated the expression of claudin-1, claudin-2, claudin-3, claudin-4, claudin-5, ZO-1, and occludin.
Gene_expression (expression) of ZO-1 in ileum
12) Confidence 0.30 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.67 Pain Relevance 0.15
Claudin-1, claudin-2, claudin-3, claudin-5, ZO-1, and occludin expression was observed in the recovering epithelium, but the reticular pattern was partly disrupted and irregular at the apical surfaces.
Gene_expression (expression) of ZO-1 in epithelium
13) Confidence 0.30 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.28 Pain Relevance 0.07
The reticular pattern of the tight junction protein ZO-1, occludin and claudin-1, -3, and -5 expression observed at 24 hr post-reperfusion may reflect the functional recovery of tight junctions.
Gene_expression (expression) of ZO-1
14) Confidence 0.30 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.36 Pain Relevance 0.11
Claudin-1, claudin-3, claudin-5, ZO-1, and occludin were expressed in linear fashion along the whole surface of the epithelial cells from the crypts to the villi with a typical reticular pattern (Fig. 3A1, C1, E1–G1).
Gene_expression (expressed) of ZO-1 in epithelial cells
15) Confidence 0.30 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.65 Pain Relevance 0.15
Claudin 4, claudin 18, and occludin were all significantly reduced in 2CLP monolayers compared to sham, while no significant differences in the expression of claudin 3, 5, 7, 8, ZO-1, and JAM-A were observed.
Gene_expression (expression) of ZO-1
16) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.14 Pain Relevance 0
In the crypt, the reticular pattern of tight-junction protein expression was observed.
Gene_expression (expression) of tight-junction protein
17) Confidence 0.26 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.12 Pain Relevance 0.03
Furthermore, it would be of value to study what changes in tight-junction protein expression occur in humans, such as patients with ischemic and inflammatory bowel disease, with the goal of understanding the pathogenesis more clearly.



Gene_expression (expression) of tight-junction protein in bowel associated with inflammation
18) Confidence 0.26 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.44 Pain Relevance 0.13
Changes in tight-junction protein expression during ischemia-reperfusion injury
Gene_expression (expression) of tight-junction protein associated with reperfusion injury and ischemia
19) Confidence 0.26 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.60 Pain Relevance 0.14
Extended focus images of the tight-junction proteins showed spotty expression with only partly reticular pattern at the surface of the epithelium (Fig. 3A3–C3, E3–G3), whereas the reticular pattern of tight-junction protein expression was observed in the crypt.
Gene_expression (expression) of tight-junction protein in epithelium
20) Confidence 0.26 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.14 Pain Relevance 0.04

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