INT10534

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Latest revision as of 12:16, 23 September 2012

Context Info
Confidence 0.60
First Reported 1982
Last Reported 2010
Negated 3
Speculated 9
Reported most in Abstract
Documents 209
Total Number 219
Disease Relevance 78.75
Pain Relevance 81.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
neurons 12
dorsal root ganglion 9
brain 6
spinal 4
hearts 4
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 319 100.00 Very High Very High Very High
qutenza 176 100.00 Very High Very High Very High
Dopamine 128 100.00 Very High Very High Very High
Glutamate receptor 73 100.00 Very High Very High Very High
Lasting pain 69 100.00 Very High Very High Very High
Anterior cingulate cortex 42 100.00 Very High Very High Very High
Opioid 124 99.98 Very High Very High Very High
opiate 26 99.98 Very High Very High Very High
Nerve growth factor 179 99.96 Very High Very High Very High
agonist 319 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 511 100.00 Very High Very High Very High
Pain 409 100.00 Very High Very High Very High
Cold Sores 9 100.00 Very High Very High Very High
Vibrio Infection 3 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 37 99.92 Very High Very High Very High
Hypoxia 53 99.84 Very High Very High Very High
Neointima 42 99.84 Very High Very High Very High
Apoptosis 586 99.78 Very High Very High Very High
Obesity 63 99.74 Very High Very High Very High
Bordatella Infection 24 99.72 Very High Very High Very High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, there was an upregulation of protein kinase Cgamma and a progressive downregulation of mu-opioid receptors within the spinal cord dorsal horn ipsilateral to injury as revealed by immunohistochemistry and Western blot.
Positive_regulation (upregulation) of kinase in spinal cord dorsal horn associated with injury, dorsal horn, mu opioid receptor and spinal cord
1) Confidence 0.60 Published 2005 Journal Pain Section Abstract Doc Link 15936884 Disease Relevance 1.84 Pain Relevance 1.06
Increases in the serum levels of creatine kinase were monitored for 24 hours, and the weight, as well as macro- and microscopic changes in the muscle for a period of 1 month.
Positive_regulation (Increases) of kinase in muscle
2) Confidence 0.45 Published 1988 Journal Toxicol Pathol Section Abstract Doc Link 3222624 Disease Relevance 0.16 Pain Relevance 0.28
Persistent nociceptive behavior in rats induced by subcutaneous formalin injection was significantly reduced by intrathecal pretreatment with a phospholipase C inhibitor (neomycin), and an inhibitor of protein kinase C (W-7), and was significantly enhanced by a phorbol ester (phorbol 12-myristate 13-acetate, PMA) and a stimulator of protein kinase C (SC-10).
Positive_regulation (stimulator) of kinase associated with nociception, kinase c and intrathecal
3) Confidence 0.42 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1501774 Disease Relevance 0.51 Pain Relevance 0.55
It is expected that noxious inputs associated with tissue injury produce a release of aspartate and glutamate within the spinal dorsal horn which by acting at ionotropic (NMDA) and metabotropic excitatory amino acid receptors produce an increase in intracellular messengers such as calcium and diacylglycerol which stimulate protein kinase C.
Positive_regulation (stimulate) of kinase in dorsal horn associated with kinase c, glutamate, spinal dorsal horn, injury and excitatory amino acid
4) Confidence 0.42 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1501774 Disease Relevance 0.46 Pain Relevance 0.54
Creatine kinase and pyruvate kinase are two thiol-containing enzymes that exert a key role for cellular energy homeostasis in brain.
Positive_regulation (pyruvate) of kinase in brain
5) Confidence 0.42 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19925858 Disease Relevance 0.26 Pain Relevance 0
Creatine kinase and pyruvate kinase are two thiol-containing enzymes that exert a key role for cellular energy homeostasis in brain.
Positive_regulation (Creatine) of kinase in brain
6) Confidence 0.42 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19925858 Disease Relevance 0.26 Pain Relevance 0
Although the cAMP second messenger system contributes to primary afferent hyperalgesia, we found no evidence for a contribution of protein kinase C.
Positive_regulation (contribution) of kinase associated with kinase c and hyperalgesia
7) Confidence 0.26 Published 1991 Journal Neuroscience Section Abstract Doc Link 1722888 Disease Relevance 0.76 Pain Relevance 1.35
Sevoflurane activates phospholipase C and protein kinase C, leading to an increase in intracellular Ca(2+) concentration, which modulates glucose transport.
Positive_regulation (activates) of kinase associated with kinase c
8) Confidence 0.26 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12088955 Disease Relevance 0 Pain Relevance 0.05
Using activity ratios to judge the extent of activation of cAMP-dependent protein kinase in vivo, it was found that isoproterenol-induced increases in cAMP protein kinase activity were similar in control and acutely-treated animals, but were reduced with repeated desipramine treatment.
Positive_regulation (increases) of kinase associated with desipramine
9) Confidence 0.26 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2937646 Disease Relevance 0 Pain Relevance 0.54
Using activity ratios to judge the extent of activation of cAMP-dependent protein kinase in vivo, it was found that isoproterenol-induced increases in cAMP protein kinase activity were similar in control and acutely-treated animals, but were reduced with repeated desipramine treatment.
Positive_regulation (activation) of kinase associated with desipramine
10) Confidence 0.26 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2937646 Disease Relevance 0 Pain Relevance 0.52
The extent of protein kinase activation was also elevated by both acute and repeated treatment in the absence of isoproterenol.
Positive_regulation (activation) of kinase
11) Confidence 0.26 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2937646 Disease Relevance 0 Pain Relevance 0.53
We have found that chronic opiates increase levels of the G-protein subunits Gi alpha and Go alpha, adenylate cyclase, cyclic AMP-dependent protein kinase, and a number of phosphoproteins (including tyrosine hydroxylase) in this brain region.
Positive_regulation (increase) of kinase in brain associated with opiate
12) Confidence 0.26 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 8385277 Disease Relevance 0.17 Pain Relevance 0.73
In contrast to the acute effects of opiates, chronic treatment of rats with opiates increases levels of specific G-protein subunits, adenylate cyclase, cyclic AMP-dependent protein kinase, and a number of phosphoproteins (including tyrosine hydroxylase) in this brain region.
Positive_regulation (increases) of kinase in brain associated with opiate
13) Confidence 0.22 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7859110 Disease Relevance 0.09 Pain Relevance 0.94
Inhibition of glycine receptors occurred via a postsynaptic mechanism involving the activation of EP2 receptors, cholera-toxin-sensitive G-proteins and cAMP-dependent protein kinase.
Positive_regulation (activation) of kinase associated with vibrio infection
14) Confidence 0.22 Published 2002 Journal Nat. Neurosci. Section Abstract Doc Link 11740501 Disease Relevance 0.33 Pain Relevance 0.61
Exposure of arrested hearts to 0.2 mM methacholine, a muscarinic-cholinergic agonist, for 5 minutes before elevation of perfusion pressure blocked the pressure-induced increases in cAMP content, cAMP-dependent protein kinase activity, and rates of protein synthesis.
Positive_regulation (increases) of kinase in hearts associated with agonist
15) Confidence 0.22 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2475273 Disease Relevance 0.09 Pain Relevance 0.13
Furthermore, application of a membrane permeable analog of 5'-AMP, 8-bromo-5'-AMP, the cyclic AMP metabolite that does not activate a protein kinase, potently reduced the amplitudes of single action potential afterhyperpolarizations.
Neg (not) Positive_regulation (activate) of kinase associated with action potential
16) Confidence 0.22 Published 1994 Journal Neuroscience Section Abstract Doc Link 7830895 Disease Relevance 0 Pain Relevance 0.63
This action may be mediated through a mechanism independent of protein kinase activation.
Positive_regulation (activation) of kinase
17) Confidence 0.22 Published 1994 Journal Neuroscience Section Abstract Doc Link 7830895 Disease Relevance 0 Pain Relevance 0.50
METHODS: The effects of bupivacaine on the activation of extracellular receptor-activated kinase (phosphorylation to pERK) in rat spinal cord slices, induced by presynaptic release (capsaicin), by presynaptic or postsynaptic ionotropic or metabotropic receptor activation, or by activation of intracellular protein kinase C or protein kinase A and also by a receptor-independent Ca2+ ionophore, were quantitated by immunohistochemistry, counting pERK-positive neurons in the superficial dorsal horn.
Positive_regulation (activation) of kinase in neurons
18) Confidence 0.22 Published 2006 Journal Anesthesiology Section Body Doc Link 16571978 Disease Relevance 0.08 Pain Relevance 0
METHODS: The effects of bupivacaine on the activation of extracellular receptor-activated kinase (phosphorylation to pERK) in rat spinal cord slices, induced by presynaptic release (capsaicin), by presynaptic or postsynaptic ionotropic or metabotropic receptor activation, or by activation of intracellular protein kinase C or protein kinase A and also by a receptor-independent Ca2+ ionophore, were quantitated by immunohistochemistry, counting pERK-positive neurons in the superficial dorsal horn.
Positive_regulation (activation) of kinase in neurons
19) Confidence 0.22 Published 2006 Journal Anesthesiology Section Body Doc Link 16571978 Disease Relevance 0.08 Pain Relevance 0
These results show that the concentration and extent of activation of cAMP protein kinase is altered following desipramine treatment in the rat pineal gland and that modulation of cAMP protein kinase may be a locus of regulation for desipramine-mediated reduction in noradrenergic responsiveness.
Positive_regulation (activation) of kinase in pineal gland associated with desipramine
20) Confidence 0.19 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2937646 Disease Relevance 0 Pain Relevance 0.46

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