INT10555

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Context Info
Confidence 0.75
First Reported 1987
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 37
Total Number 39
Disease Relevance 7.81
Pain Relevance 17.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (FLII) cytoskeleton (FLII) nucleus (FLII)
cytoplasm (FLII)
Anatomy Link Frequency
spinal cord 6
spinal 3
dorsum 2
dorsal horn 2
neurons 2
FLII (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 100 100.00 Very High Very High Very High
Spinal cord 74 100.00 Very High Very High Very High
Pain 63 100.00 Very High Very High Very High
narcan 38 100.00 Very High Very High Very High
MU agonist 3 99.96 Very High Very High Very High
anesthesia 18 99.88 Very High Very High Very High
local anesthetic 6 99.82 Very High Very High Very High
Hyperalgesia 12 99.78 Very High Very High Very High
carrageenan induced 2 99.74 Very High Very High Very High
spinal dorsal horn 11 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 28 100.00 Very High Very High Very High
Pressure And Volume Under Development 6 99.92 Very High Very High Very High
Hyperalgesia 14 99.78 Very High Very High Very High
Urological Neuroanatomy 5 98.48 Very High Very High Very High
Hypoalagesia 2 97.60 Very High Very High Very High
Toxocariasis 3 95.24 Very High Very High Very High
Nervous System Injury 12 95.16 Very High Very High Very High
Injury 25 94.84 High High
Nociception 42 94.20 High High
Contusions 6 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(vii) A higher level of urethane anaesthesia had a generally suppressive effect on FLI expression.
Gene_expression (expression) of FLI
1) Confidence 0.75 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8930788 Disease Relevance 0.21 Pain Relevance 0.18
(v) This increase in FLI was expressed bilaterally and restricted largely to the intermediate white layer.
Gene_expression (expressed) of FLI
2) Confidence 0.65 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8930788 Disease Relevance 0.20 Pain Relevance 0.06
(vii) No reliable differences in the spatial topography of FLI expression were observed when unilateral noxious mechanical stimulation was administered to the face or hind foot.
Gene_expression (expression) of FLI in foot
3) Confidence 0.65 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8930788 Disease Relevance 0.24 Pain Relevance 0.13
CONCLUSION: Pretreatment with intravenous ketamine inhibits inflammatory pain behavior and FLI expression following a formalin injection in rats, suggesting that pretreatment of ketamine plays an important role in preemptive analgesia.


Gene_expression (expression) of FLI
4) Confidence 0.58 Published 2005 Journal Acta Anaesthesiol Scand Section Body Doc Link 15715615 Disease Relevance 0 Pain Relevance 0
In addition to the pericardial organs, significant levels of FLI were found in neurosecretory regions associated with thoracic second roots and in the connective tissue sheath that surrounds the ventral nerve cord.
Gene_expression (levels) of FLI in connective tissue
5) Confidence 0.49 Published 1987 Journal J. Comp. Neurol. Section Abstract Doc Link 3323267 Disease Relevance 0.22 Pain Relevance 0.13
Compared with baseline levels, urethane and avertin anaesthesia induced FLI expression in the SC intermediate layers, although the FLI response to both noxious stimulation and control conditions was differentially suppressed in different layers of the SC by anaesthesia.
Gene_expression (expression) of FLI
6) Confidence 0.39 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10975882 Disease Relevance 0.28 Pain Relevance 0
The number of FLI neurons in the lateral one-third was similar in the two operations, indicating that neurons expressing FLI in the medial two-thirds and in the lateral one-third of the superficial layer after nerve transection are derived from nerve injury and tissue injury, respectively.
Gene_expression (expressing) of FLI in neurons associated with nervous system injury and injury
7) Confidence 0.30 Published 2002 Journal Brain Res. Section Abstract Doc Link 11937072 Disease Relevance 0.28 Pain Relevance 0.35
At 2 days, injection of the local anesthetic subcutaneously in the dorsum of neck, to control for a systemic action, also reduced expression of FLI in laminae 1 and 2; at 2 weeks, the systemic injection of the local anesthetic reduced expression of FLI throughout the gray matter of the spinal cord.
Gene_expression (expression) of FLI in dorsum associated with spinal cord and local anesthetic
8) Confidence 0.21 Published 1993 Journal Brain Res. Section Abstract Doc Link 8402151 Disease Relevance 0.47 Pain Relevance 0.84
Higher doses of icv Cl-977 that suppressed formalin-evoked behaviors did not inhibit the expression of FLI in any region of the spinal cord.
Gene_expression (expression) of FLI in spinal cord associated with spinal cord
9) Confidence 0.19 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632353 Disease Relevance 0.12 Pain Relevance 0.83
Finally, neither the inhibitory effect of 4.40 nmol Cl-977 on formalin-evoked behaviors nor the formalin-evoked pattern of FLI expression in the spinal cord of rats treated with this dose of Cl-977 was affected by lesions of the dorsolateral funiculus.
Gene_expression (expression) of FLI in spinal cord associated with spinal cord
10) Confidence 0.19 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632353 Disease Relevance 0.06 Pain Relevance 0.76
The lowest dose of icv Cl-977 tested (0.13 nmol) produced a 50% reduction in FLI in the superficial laminae but did not inhibit the expression of FLI in any other regions of the spinal cord.
Gene_expression (expression) of FLI in spinal cord associated with spinal cord
11) Confidence 0.19 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632353 Disease Relevance 0.14 Pain Relevance 0.75
In previous studies, we reported that supraspinally administered DAMGO, a mu-opioid agonist, produces a dose-related, naloxone-reversible inhibition of formalin-evoked pain behaviors and spinal cord Fos-like immunoreactivity (FLI) in the rat spinal cord.
Gene_expression (produces) of FLI in spinal cord associated with pain, mu agonist, narcan and spinal cord
12) Confidence 0.17 Published 1996 Journal Pain Section Abstract Doc Link 8826484 Disease Relevance 0.17 Pain Relevance 1.06
At 2 days, injection of the local anesthetic subcutaneously in the dorsum of neck, to control for a systemic action, also reduced expression of FLI in laminae 1 and 2; at 2 weeks, the systemic injection of the local anesthetic reduced expression of FLI throughout the gray matter of the spinal cord.
Gene_expression (expression) of FLI in dorsum associated with spinal cord and local anesthetic
13) Confidence 0.16 Published 1993 Journal Brain Res. Section Abstract Doc Link 8402151 Disease Relevance 0.46 Pain Relevance 0.82
No FLI was found in the brains of these rats.
Neg (No) Gene_expression (found) of FLI in brains
14) Confidence 0.15 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1527597 Disease Relevance 0.14 Pain Relevance 0.49
After 1 h of urethane anesthesia, low levels of FLI were found in the following areas: nucleus of the tractus solitarius (NTS); caudal and rostral ventrolateral medulla (VLM); lateral PBN; ventromedial, paraventricular, and supraoptic nuclei (SON) of the hypothalamus; medial preoptic area; central nucleus of the amygdala (ACE); endopiriform cortex; insular cortex; piriform cortex; and islands of Calleja.
Gene_expression (levels) of FLI in ACE associated with rostral ventrolateral medulla, anesthesia, toxocariasis, urological neuroanatomy and amygdala
15) Confidence 0.15 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1527597 Disease Relevance 0.19 Pain Relevance 0.55
However, blockade of peripheral 5-HT1A receptors by (N-2-[4-(2-methoxyphenyl-1-piperazinyl] ethyl]-N-2-pyridinylcyclohexanecarboxamide at maximally effective doses (30 and 100 mug; i.pl.) did not alter carrageenan-induced hyperalgesia, edema or expression of FLI.
Gene_expression (expression) of FLI associated with pressure and volume under development and hyperalgesia
16) Confidence 0.14 Published 2005 Journal Neuroscience Section Abstract Doc Link 15857711 Disease Relevance 0.69 Pain Relevance 0.77
In rats killed 1 hr after anesthesia with sodium pentobarbital, FLI was found only in the habenulae.
Gene_expression (found) of FLI in habenulae associated with anesthesia
17) Confidence 0.12 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1527597 Disease Relevance 0.16 Pain Relevance 0.51
INTERPRETATION & CONCLUSION: The results provide evidence that intrathecal ketamine does not have a preemptive blocking effect of FLI expression in whole spinal laminae area.
Gene_expression (expression) of FLI in spinal
18) Confidence 0.11 Published 2004 Journal Indian J. Med. Res. Section Body Doc Link 15654138 Disease Relevance 0.07 Pain Relevance 0
Intraperitoneal injection of 3.5% acetic acid in the unanesthetized rat evoked the expression of FLI in a discrete population of spinal cord neurons, the distribution of which closely mirrored the spinal terminations of visceral primary afferents.
Gene_expression (expression) of FLI in spinal associated with spinal cord
19) Confidence 0.11 Published 1992 Journal J. Comp. Neurol. Section Abstract Doc Link 1545011 Disease Relevance 0.15 Pain Relevance 0.81
Carrageenan induced conspicuous expression of c-fos-like immunoreactivity (FLI) in the spinal dorsal horn of segments L4-5.
Gene_expression (expression) of FLI in dorsal horn associated with spinal dorsal horn and carrageenan induced
20) Confidence 0.09 Published 2005 Journal Neuroscience Section Abstract Doc Link 15857711 Disease Relevance 0.72 Pain Relevance 0.79

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