INT105771

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH, GNRH1) extracellular space (CRH, GNRH1) extracellular region (CRH, GNRH1)
cell-cell signaling (GNRH1) response to stress (CRH)
Anatomy Link Frequency
thyroid 2
CRH (Homo sapiens)
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 1 98.92 Very High Very High Very High
Hippocampus 1 96.72 Very High Very High Very High
amygdala 2 95.92 Very High Very High Very High
analgesia 1 90.24 High High
Pain 1 88.56 High High
Locus ceruleus 1 66.48 Quite High
depression 3 25.00 Low Low
Inflammation 2 25.00 Low Low
Inflammatory response 1 25.00 Low Low
Fibrositis 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 7 99.68 Very High Very High Very High
Pain 1 88.56 High High
Depression 4 25.00 Low Low
INFLAMMATION 3 25.00 Low Low
Hypertension 1 25.00 Low Low
Sleep Disorders 1 25.00 Low Low
Insulin Resistance 1 25.00 Low Low
Dyslipidemia /

Combined Dyslipidemia

1 25.00 Low Low
Metabolic Syndrome 1 25.00 Low Low
Osteoporosis 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRH plays an important role in inhibiting GnRH secretion during stress, while, via somatostatin, it also inhibits GH, TRH and TSH secretion, suppressing, thus, the reproductive, growth and thyroid functions.
CRH Negative_regulation (inhibiting) of Localization (secretion) of GnRH in thyroid associated with stress and somatostatin
1) Confidence 0.35 Published 2002 Journal J Psychosom Res Section Abstract Doc Link 12377295 Disease Relevance 0.56 Pain Relevance 0.39

General Comments

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