INT105784

From wiki-pain
Revision as of 21:32, 20 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 1.29
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Nrg1) extracellular space (Nrg1) cell morphogenesis (Nrg1)
plasma membrane (Nrg1) cytoplasm (Nrg1)
Anatomy Link Frequency
radial 3
neuronal 1
Notch 1
plasma 1
Schwann cell 1
Nrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 4 99.96 Very High Very High Very High
Nicotine 36 97.04 Very High Very High Very High
Analgesic 4 95.40 Very High Very High Very High
Central grey 11 91.24 High High
midbrain 1 90.44 High High
Spinal cord 3 86.24 High High
Glutamate 11 83.64 Quite High
Neurotransmitter 12 81.64 Quite High
excitatory amino acid 3 77.76 Quite High
Demyelination 16 76.60 Quite High
Disease Link Frequency Relevance Heat
Lifespan 3 99.44 Very High Very High Very High
Urological Neuroanatomy 12 91.24 High High
Neurodegenerative Disease 34 79.24 Quite High
Demyelinating Disease 17 76.60 Quite High
Targeted Disruption 21 70.96 Quite High
Disseminated Intravascular Coagulation 40 63.84 Quite High
Nervous System Malformation 1 62.80 Quite High
Disease 83 54.00 Quite High
Frontotemporal Dementia 8 53.04 Quite High
Stress 8 52.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The intracellular domains of Type III Nrg1 lack known functional motifs that could mediate protein–protein interactions.
Nrg1 Binding (interactions) of
1) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.15
If Type III Nrg1 signaling does continue to regulate presynaptic levels of ?
Nrg1 Binding (continue) of
2) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.15 Pain Relevance 0.23
Any of these mechanisms might represent convergent targets with Type III Nrg1–PtdIns 3K signaling for influencing the rate of ER/Golgi to plasma membrane trafficking of ?
Nrg1 Spec (might) Binding (targets) of in plasma
3) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.23
The pathways activated by established Schwann cell signals, such as cAMP and neuregulin, are actively being clarified as exemplified by the work on GPR126 and NF-?
neuregulin Binding (exemplified) of in Schwann cell
4) Confidence 0.23 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0.33 Pain Relevance 0.17
M KU-32 for 6 h, followed by 100 ng/ml of NRG1 (human recombinant neuregulin-1-?
neuregulin-1 Binding (recombinant) of
5) Confidence 0.22 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0 Pain Relevance 0.06
NRG1 does not improve neuronal migration toward the cortical plate
NRG1 Binding (migration) of in neuronal
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.06 Pain Relevance 0
Therefore, the soluble EGF-like domain of type I NRG1, applied diffusely or focally, is sufficient to realign vimentin+ radial glia, which are highly disrupted in MAM treated animals; BLBP+ radial glia, although less disrupted, remain unchanged.


type I NRG1 Binding (domain) of in radial
7) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
To further elucidate the mechanism of radial glial radialization induced by NRG1, MAM slices were cultured in medium containing recombinant NRG1 (1 nM) combined with HER-3 Ab-5 or HER-4 Ab-3, two antibodies blocking the binding of NRG1 to erbB3 and erbB4 respectively (Figure S1).
NRG1 Binding (binding) of in radial
8) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
To test whether the full length type I NRG1 or membrane bound type III NRG1 could improve radial migration, MAM slices were co-cultured with Ig-NRG1 or CRD-NRG1 HEK cells.
type III NRG1 Binding (bound) of in radial
9) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.06 Pain Relevance 0
Similarly to Notch processing, upon neuregulin binding and activation of ErbB4, ?
neuregulin Binding (binding) of in Notch
10) Confidence 0.03 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.32 Pain Relevance 0.03
These receptors specifically bind the type-1 histamine antagonist, levocabastine.
type-1 histamine Binding (bind) of associated with antagonist
11) Confidence 0.00 Published 2002 Journal Neuroscience Section Abstract Doc Link 12379249 Disease Relevance 0.36 Pain Relevance 0.65

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox