INT105849

Context Info Confidence 0.07 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 0.38 Pain Relevance 0.51

aging (Il1b, Ptgs1) nuclear envelope (Ptgs1) Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)

Anatomy Link Frequency afferent neurons 2 Il1b (Rattus norvegicus) Ptgs1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat COX2 1 99.18 substance P 8 98.04 dorsal root ganglion 7 92.44 COX-2 inhibitor 1 48.72 Inflammation 1 25.00 Hyperalgesia 1 24.48

Disease Link Frequency Relevance Heat Ganglion Cysts 7 91.96 Hyperalgesia 1 5.00 Nociception 1 5.00 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Nitric oxide synergistically potentiates interleukin-1 beta-induced increase of cyclooxygenase-2 mRNA levels, resulting in the facilitation of substance P release from primary afferent neurons: involvement of cGMP-independent mechanisms.

interleukin-1 beta Positive_regulation (induced) of Positive_regulation (increase) of cyclooxygenase in afferent neurons associated with cox2 and substance p

1) Confidence 0.07 Published 2002 Journal Neuropharmacology Section Title Doc Link 12384172 Disease Relevance 0.38 Pain Relevance 0.51

General Comments

This test has worked.