INT105883

From wiki-pain
Revision as of 16:14, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.67
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 14 99.98 Very High Very High Very High
vincristine 3 99.88 Very High Very High Very High
Clonidine 6 89.28 High High
withdrawal 8 76.24 Quite High
cerebral cortex 2 75.00 Quite High
Paresthesia 2 74.88 Quite High
adenocard 1 73.36 Quite High
cINOD 3 71.80 Quite High
dexamethasone 2 53.76 Quite High
Analgesic 15 47.04 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 18 100.00 Very High Very High Very High
Hypoxia 20 99.98 Very High Very High Very High
Chronic Lymphoid Leukemia 27 99.68 Very High Very High Very High
Poisoning 1 99.54 Very High Very High Very High
Prostate Cancer 90 98.78 Very High Very High Very High
Cancer 24 97.38 Very High Very High Very High
Toxicity 24 82.84 Quite High
Colon Cancer 3 81.36 Quite High
Injury 3 80.28 Quite High
Death 3 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because microtubule-active drugs such as vincristine also induced G(2)-M arrest and Bcl2 phosphorylation in WSU-CLL, whereas the genotoxic drugs etoposide and doxorubicin did not, we examined the effect of CP461 on microtubules by indirect immunofluoresence microscopy.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Bcl2 associated with chronic lymphoid leukemia and vincristine
1) Confidence 0.32 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12384529 Disease Relevance 0.88 Pain Relevance 0.12
Although CP461 induces p53 up-regulation, G(2)-M arrest and Bcl2 phosphorylation were independent of p53.
Neg (independent) Positive_regulation (independent) of Phosphorylation (phosphorylation) of Bcl2
2) Confidence 0.32 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12384529 Disease Relevance 0.78 Pain Relevance 0.12
In addition, administration of arjunolic acid 4 h after acetaminophen intoxication reduced acetaminophen-induced JNK and downstream Bcl-2 and Bcl-xL phosphorylation, thus protecting against mitochondrial permeabilization, loss of mitochondrial membrane potential, and cytochrome c release.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Bcl-2 associated with paracetamol and poisoning
3) Confidence 0.27 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19969075 Disease Relevance 0.57 Pain Relevance 1.01
Neither sulindac sulfide (a cyclooxygenase inhibitor) nor sulindac sulfone induced G(2)-M arrest, Bcl2 phosphorylation, microtubule disassembly, or cell shape changes.
Neg (nor) Positive_regulation (induced) of Phosphorylation (phosphorylation) of Bcl2
4) Confidence 0.23 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12384529 Disease Relevance 0.84 Pain Relevance 0.09
The present study aims to investigate the mechanism of phosphorylation of apoptotic proteins and tests the hypothesis that the hypoxia-induced increased tyrosine phosphorylation of apoptotic proteins Bcl-2 and Bcl-xl is Ca(2+)-influx-dependent.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Bcl-2 associated with hypoxia and apoptosis
5) Confidence 0.02 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19597709 Disease Relevance 0.87 Pain Relevance 0.21
The present study aims to investigate the mechanism of phosphorylation of apoptotic proteins and tests the hypothesis that the hypoxia-induced increased tyrosine phosphorylation of apoptotic proteins Bcl-2 and Bcl-xl is Ca(2+)-influx-dependent.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Bcl-2 associated with hypoxia and apoptosis
6) Confidence 0.02 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19597709 Disease Relevance 0.87 Pain Relevance 0.21
The studies to evaluate the ability of docetaxel to stabilize tubulin, found that it had a significant anti-tumor effect in androgen-dependent and androgen-independent prostate cancer cell lines.11,12 In addition, docetaxel caused apoptosis by inducing phosphorylation of bcl-2, which found to be overexpressed in androgen-resistant prostate cancer.13 Thus, these in vitro results encouraged the clinical use of docetaxel in HRPC patients.
Positive_regulation (inducing) of Phosphorylation (phosphorylation) of bcl-2 associated with cancer, prostate cancer and apoptosis
7) Confidence 0.01 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615369 Disease Relevance 0.87 Pain Relevance 0.04
Docetaxel induces polymerization of microtubules and phosphorylation of bcl-2 protein.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of bcl-2 protein
8) Confidence 0.01 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1550253 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox