INT105920

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Context Info
Confidence 0.36
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.99
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC9A3R2) nucleus (SLC9A3R2) protein complex assembly (SLC9A3R2)
cytoplasm (SLC9A3R2)
Anatomy Link Frequency
joint 2
quadriceps 1
leg 1
SLC9A3R2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 13 99.44 Very High Very High Very High
Rsd 1 99.20 Very High Very High Very High
Pain 21 95.84 Very High Very High Very High
Osteoarthritis 76 86.48 High High
diclofenac 1 73.40 Quite High
Paracetamol 1 71.72 Quite High
Arthritis 3 5.00 Very Low Very Low Very Low
Pain score 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteolysis 9 99.26 Very High Very High Very High
Complex Regional Pain Syndromes 1 99.20 Very High Very High Very High
Cancer 1 98.36 Very High Very High Very High
Neurologic Manifestations 1 97.52 Very High Very High Very High
Pain 23 95.84 Very High Very High Very High
Obesity 24 95.54 Very High Very High Very High
Knee Osteoarthritis 46 86.48 High High
Arthropathy 3 86.40 High High
Osteoarthritis 24 84.88 Quite High
Overweight 4 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The exclusion criteria were patients having a TKA re-revision, revision for failed unicondylar prosthesis, patients with metastatic or primary tumour of the knee, reflex sympathetic dystrophy of the leg, subject medically unfit to undergo TKAR, progressive muscular condition (with quadriceps weakness), neurologic deficit of affected limb, knee pain associated with spinal pathology, patient declined participation.
TKA Binding (undergo) of in leg associated with pain, rsd, cancer and neurologic manifestations
1) Confidence 0.36 Published 2007 Journal J Orthop Surg Section Body Doc Link PMC2225391 Disease Relevance 0.39 Pain Relevance 0.20
Independent t-tests were performed to determine if significant differences in age, BMI, TUG, SCT, KOS-ADLS, quadriceps strength on the involved and uninvolved side, active knee extension range of motion and active knee flexion range of motion existed between persons who did and persons who did not choose to undergo TKA within two years of evaluation.
TKA Binding (undergo) of in quadriceps associated with obesity
2) Confidence 0.27 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.34 Pain Relevance 0.08
A secondary objective was to examine the multivariate association between preoperative joint loading and BMI on the one hand and post-TKA implant migration on the other.


TKA Binding (migration) of in joint
3) Confidence 0.07 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917572 Disease Relevance 0.51 Pain Relevance 0.11
Subjective outcome questionnaires tend to reflect the reduction of symptoms associated with TKA and not the functional state of the joint.
TKA Binding (associated) of in joint
4) Confidence 0.07 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917572 Disease Relevance 0.26 Pain Relevance 0.17
Osteolysis has been well documented as a major complication after TKA [34-37].
TKA Binding (complication) of associated with osteolysis
5) Confidence 0.05 Published 2007 Journal J Orthop Surg Section Body Doc Link PMC1784078 Disease Relevance 0.34 Pain Relevance 0
In conclusion, hOATs and hOCTs interacted with various NSAIDs, whereas hOATs but not hOCTs mediated the transport of some of these NSAIDs.
hOCTs Binding (interacted) of associated with cinod
6) Confidence 0.00 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12388633 Disease Relevance 0.14 Pain Relevance 1.19

General Comments

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