INT106063

Context Info Confidence 0.11 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 1.13

nucleus (POU2F2) cytoplasm (POU2F2)

POU2F2 (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 10 98.20 Opioid 2 90.00 orphanin 4 75.00 Ventral tegmentum 1 65.84 Locus ceruleus 1 64.40 Catecholamine 2 62.28 withdrawal 1 51.28 analgesia 2 48.84 Pain 1 43.12 opioid receptor 1 40.72

Disease Link Frequency Relevance Heat Neuroblastoma 1 72.32 Pain 1 43.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, chronic OFQ/N exposure increased levels of the TH gene repressor, Oct-2, irrespective of the presence or absence of morphine.

Positive_regulation (increased) of Gene_expression (levels) of Oct-2 associated with morphine

1) Confidence 0.11 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399106 Disease Relevance 0.07 Pain Relevance 1.13

General Comments

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