INT106183

Context Info Confidence 0.19 First Reported 2003 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.03 Pain Relevance 0.28

extracellular space (IL5) extracellular region (IL5)

IL5 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 96 100.00 Pain 1 75.32 antagonist 34 62.88 cytokine 93 52.84 chemokine 24 52.48 agonist 20 5.00 Inflammatory response 6 5.00 methotrexate 4 5.00 Inflammatory mediators 2 5.00 withdrawal 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 103 100.00 Asthma 315 93.20 Hyperplasia 9 89.76 Cancer 7 84.48 Pain 1 75.32 Targeted Disruption 23 75.00 Neuroblastoma 3 75.00 Panniculitis 1 74.20 Adverse Drug Reaction 1 72.60 Pulmonary Eosinophilia 1 66.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Supernatant collected from restimulated cells showed increased amounts of IL-4 (11.4-fold; P =.021) and IL-5 (8.7-fold; P =.002).

Negative_regulation (amounts) of Positive_regulation (increased) of IL-5

1) Confidence 0.19 Published 2003 Journal Blood Section Abstract Doc Link 12406881 Disease Relevance 0.77 Pain Relevance 0.13

Vaccination significantly inhibits increase in inflammatory cell number and IL-13 and IL-5 levels in BAL.

Negative_regulation (inhibits) of Positive_regulation (increase) of IL-5 associated with inflammation

2) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.26 Pain Relevance 0.15

General Comments

This test has worked.