INT106253

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Context Info
Confidence 0.29
First Reported 2002
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 3.88
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HNF4A) nucleoplasm (HNF4A) nucleus (HNF4A)
DNA binding (HNF4A) cytoplasm (HNF4A)
Anatomy Link Frequency
liver 1
colon 1
T-cell 1
HNF4A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 21 83.36 Quite High
Inflammation 16 76.76 Quite High
antagonist 25 74.00 Quite High
aspirin 14 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 121 99.72 Very High Very High Very High
Repression 14 98.88 Very High Very High Very High
Familial Adenomatous Polyposis 19 97.88 Very High Very High Very High
Stress 64 91.76 High High
Hypoxia 34 88.72 High High
Obesity 80 86.56 High High
Apoptosis 86 82.24 Quite High
INFLAMMATION 26 81.92 Quite High
Carcinoma 3 70.80 Quite High
Cancer 180 69.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutations in the adenomatous polyposis coli (APC) gene, which initiate almost all human colon cancers, directly target the proto-oncogene, c-myc, by elevating beta-catenin/T-cell factor (TCF) signaling.
Positive_regulation (elevating) of TCF in T-cell associated with colon cancer and familial adenomatous polyposis
1) Confidence 0.29 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414619 Disease Relevance 0.37 Pain Relevance 0
Increased transcriptional initiation of c-myc induced by the short-chain fatty acid, butyrate, consistent with elevated beta-catenin/TCF activity, was efficiently abrogated by a block to transcriptional elongation, resulting in decreased c-myc expression. 1alpha,25-Dihydroxyvitamin D(3) also induced transcriptional blockage.
Positive_regulation (elevated) of TCF
2) Confidence 0.13 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414619 Disease Relevance 0.40 Pain Relevance 0.08
We have shown that agents ascribed chemopreventive activity for colon cancer in fact also stimulate beta-catenin/TCF activity in vitro.
Positive_regulation (stimulate) of TCF in colon associated with colon cancer
3) Confidence 0.13 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414619 Disease Relevance 0.41 Pain Relevance 0.06
Biological network analysis revealed that a number of the differentially expressed energy metabolism genes are targets of HNF4-alpha in liver and/or pancreas [25, 37].
Positive_regulation (targets) of HNF4-alpha in liver
4) Confidence 0.08 Published 2008 Journal Genes Nutr Section Body Doc Link PMC2593008 Disease Relevance 0.87 Pain Relevance 0.20
HDAC inhibitors such as butyrate and TSA, block this repression resulting in a reduction of the threshold necessary to activate Tcf transcription.
Positive_regulation (activate) of Tcf associated with repression
5) Confidence 0.06 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.37 Pain Relevance 0
-catenin/TCF transcriptional activation (Figure 5A).
Positive_regulation (activation) of TCF
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.08 Pain Relevance 0
-catenin-dependent TCF transcriptional activity via a positive feedback loop.
Positive_regulation (dependent) of TCF
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.09 Pain Relevance 0
TCF-regulated genes, including c-Myc and NOS2, were also increased by expression of ?
Positive_regulation (increased) of TCF
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.11 Pain Relevance 0
Therefore, in this context DREAM does not act as a repressor, but as an activator of VDRE-dependent transcription.
Positive_regulation (dependent) of transcription
9) Confidence 0.02 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.06 Pain Relevance 0
However, we have found that DREAM proteins in which the EF-hands or the LCDs have been mutated (1) fail to stimulate HRE-dependent transcription.
Neg (fail) Positive_regulation (stimulate) of transcription
10) Confidence 0.02 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.07 Pain Relevance 0
Therefore, HRE-dependent transcription requires the integrity of the EF-hands.
Positive_regulation (dependent) of transcription
11) Confidence 0.02 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.18 Pain Relevance 0
While miR-8 does not directly target the two putative 3' UTRs of Tcf mRNA, it may directly target the Tcf mRNA independently of its 3'UTR or through an indirect mechanism.
Neg (independently) Spec (may) Positive_regulation (target) of Tcf mRNA
12) Confidence 0.02 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.24 Pain Relevance 0
Genes, whose products are involved in the transition from G1 to S-phase appeared to be downregulated, such as cyclins (CCNA2, CCNE2, CCNF), cyclin-dependent kinase 2 (CDK2) and transcription regulators (E2F2, PCNA, SKP2), whereas transcription of inhibitory genes cyclin G2 (CCNG2), GADD45A (growth arrest and DNA-damage-inducible, alpha) and p21cip1 (cyclin-dependent kinase inhibitor 1A, CDKN1A) was increased.
Positive_regulation (increased) of transcription
13) Confidence 0.02 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.05 Pain Relevance 0
Interestingly, transcription of the aryl hydrocarbon receptor (AhR) which regulates expression of the CYPs, was also increased.
Positive_regulation (increased) of transcription
14) Confidence 0.02 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.57 Pain Relevance 0

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