INT106364

Context Info Confidence 0.01 First Reported 2002 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.65 Pain Relevance 0

mitochondrion (Tyms) methyltransferase activity (Tyms) aging (Tyms) mRNA binding (Tyms) nucleolus (Tyms) nucleus (Tyms)

Tyms (Rattus norvegicus)

Pain Link Frequency Relevance Heat palliative 2 47.52

Disease Link Frequency Relevance Heat Colon Cancer 7 96.00 Trematode Infection 1 80.00 Cholangiocarcinoma 5 78.48 Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For instance, patients overexpressing epidermal growth factor receptor and p53 with thymidylate synthase have a worse prognosis.

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of thymidylate synthase

1) Confidence 0.01 Published 2002 Journal Semin. Oncol. Section Abstract Doc Link 12422306 Disease Relevance 0.42 Pain Relevance 0

The expression of the TS gene tended to be increased but the fold change was not significantly different from their parental cell lines.

Positive_regulation (increased) of Gene_expression (expression) of TS gene

2) Confidence 0.00 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.24 Pain Relevance 0

General Comments

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