INT106396

Context Info Confidence 0.50 First Reported 2002 Last Reported 2002 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.42

nucleoplasm (MAPK3) mitochondrion (MAPK3) Golgi apparatus (MAPK3) protein complex assembly (MAPK3) protein complex (MAPK3) cytoplasm (MAPK3)

DYT10 (Homo sapiens) MAPK3 (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 3 100.00 tolerance 3 93.16 MU agonist 1 92.04 agonist 2 75.00 orphanin 2 73.00 opioid receptor 1 43.56

Disease Link Frequency Relevance Heat Neuroblastoma 1 46.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We also demonstrate that chronic OFQ/N-mediated desensitization of ORL1 and mu receptors occurs via cell-specific pathways, involving ERK1/2-dependent GRK2, or PKC-dependent and ERK1/2-independent GRK3 induction.

PKC Neg (independent) Positive_regulation (induction) of ERK1 associated with kinase c

1) Confidence 0.50 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0 Pain Relevance 0.42

General Comments

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