INT106477

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 21
Total Number 32
Disease Relevance 8.69
Pain Relevance 10.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Syp)
Anatomy Link Frequency
hippocampus 4
dentate gyrus 3
thalamus 2
synapses 2
telencephalon 1
Syp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thalamus 116 100.00 Very High Very High Very High
cerebral cortex 28 100.00 Very High Very High Very High
anesthesia 22 99.98 Very High Very High Very High
amygdala 2354 99.84 Very High Very High Very High
antidepressant 6 99.78 Very High Very High Very High
Pain 13 99.74 Very High Very High Very High
Hippocampus 171 99.68 Very High Very High Very High
long-term potentiation 208 99.66 Very High Very High Very High
Dorsal horn 3 99.20 Very High Very High Very High
Glutamate 49 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 7 100.00 Very High Very High Very High
Pain 5 99.74 Very High Very High Very High
Increased Venous Pressure Under Development 10 99.64 Very High Very High Very High
Anxiety Disorder 1216 98.94 Very High Very High Very High
Shock 329 98.00 Very High Very High Very High
Urological Neuroanatomy 6 96.16 Very High Very High Very High
Injury 17 96.00 Very High Very High Very High
Body Weight 4 95.04 Very High Very High Very High
Middle Cerebral Artery Infarction 108 93.68 High High
Neuropathic Pain 3 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synaptophysin was increased in the ipsilateral dorsal horn with a peak level on day 14 and returned to baseline on day 21 post-CCI.
Positive_regulation (increased) of Synaptophysin in dorsal horn associated with eae and dorsal horn
1) Confidence 0.68 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12429371 Disease Relevance 0.99 Pain Relevance 1.15
Western blotting on tissue taken from around the cannula tips in the LA was then performed to determine whether training-induced activation of GluR1, synapsin, and synaptophysin at LA synapses is regulated by intra-LA infusion of each of these drugs.
Spec (whether) Positive_regulation (activation) of synaptophysin in synapses associated with amygdala
2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.55 Pain Relevance 0.39
Following infusion, rats were trained, then sacrificed 24 hours after training as in our previous experiments, and Western blotting was performed on LA homogenates to determine whether training-induced activation of GluR1, synapsin, and synaptophysin at LA synapses is regulated by intra-LA infusion of each of these drugs (Figure 5a).
Spec (whether) Positive_regulation (activation) of synaptophysin in synapses associated with amygdala
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.17 Pain Relevance 0.36
We found that this general anesthesia causes permanent neuronal deletion in the most vulnerable brain regions-the cerebral cortex and the thalamus-while transiently modulating protein levels of synaptophysin, synaptobrevin, amphiphysin, SNAP-25, and CaM kinase II.
Positive_regulation (causes) of synaptophysin in cerebral cortex associated with anesthesia, thalamus and cerebral cortex
4) Confidence 0.45 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077565 Disease Relevance 0.16 Pain Relevance 0.60
Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon.
Positive_regulation (induces) of synaptophysin in telencephalon associated with antidepressant
5) Confidence 0.40 Published 2007 Journal Eur Neuropsychopharmacol Section Title Doc Link 17307340 Disease Relevance 0.15 Pain Relevance 0.44
Vaynman et al. (27) reported that exercise-induced increases in synapsin I and synaptophysin in the hippocampus were abrogated by blocking of interaction between BDNF and the BDNF receptor TrkB.
Positive_regulation (increases) of synaptophysin in hippocampus associated with hippocampus
6) Confidence 0.39 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.16 Pain Relevance 0.16
Conversely, application of exogenous NO or cGMP analogs alone induces LTP and promotes an increase in clusters of both GluR1 and synaptophysin/synapsin I puncta [26].
Positive_regulation (increase) of synaptophysin associated with long-term potentiation
7) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.30 Pain Relevance 0.35
In the present study, we have observed increases in GluR1, synapsin, synaptophysin in the LA at 24 hrs (and at longer time points) following fear conditioning; we did not examine the regulation of these proteins at shorter intervals.
Positive_regulation (increases) of synaptophysin associated with anxiety disorder and amygdala
8) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.23 Pain Relevance 0.30
Of particular relevance to the present manuscript, LTP induced by glutamate application in hippocampal cell cultures has been observed to lead to an increase in GluR1, synaptophysin, and synapsin I labeled puncta, as well as a corresponding increase in the number of sites where GluR1 and synaptophysin/synapsin I are co-localized [24].
Positive_regulation (increase) of synaptophysin associated with glutamate and long-term potentiation
9) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.29 Pain Relevance 0.41
A transient increase in synaptophysin mRNA was observed after treatment with venlafaxine and fluoxetine whereas imipramine had no effect.
Positive_regulation (increase) of synaptophysin associated with fluoxetine
10) Confidence 0.36 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17950272 Disease Relevance 0 Pain Relevance 0.73
For example, glutamate-induced LTP in hippocampal cell cultures has been shown to promote an increase in the expression of the postsynaptically-localized protein GluR1 and the presynaptically-localized proteins synapsin I and synaptophysin, as well as a corresponding increase in co-localization of GluR1 and synaptophysin/synapsin I-labeled puncta [24].
Positive_regulation (increase) of synaptophysin associated with glutamate and long-term potentiation
11) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0 Pain Relevance 0.18
For experiments involving intra-LA infusion of 8-Br-cGMP, rats were trained with 2 tone-shock pairings with a 0.5 mA shock intensity in an effort to avoid ceiling effects that might obscure observation of training-induced elevations in GluR1, synaptophysin, and synapsin protein above the level of vehicle controls [28].
Positive_regulation (elevations) of synaptophysin associated with shock and amygdala
12) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.37 Pain Relevance 0.12
In the present study, we show that auditory Pavlovian fear conditioning is associated with significant and long-lasting increases in the expression of the postsynaptically-localized protein GluR1 and the presynaptically-localized proteins synaptophysin and synapsin in the lateral amygdala (LA) within 24 hrs following training.
Positive_regulation (increases) of synaptophysin in lateral associated with anxiety disorder and amygdala
13) Confidence 0.34 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2888610 Disease Relevance 0.17 Pain Relevance 0.32
Relative to vehicle controls, naive rats given intra-LA infusion of KN-93 prior to sacrifice at the same time as the trained animals described above exhibited no significant differences in levels of GluR1, synapsin, or synaptophysin in the LA [GluR1: t(10)?
Positive_regulation (levels) of synaptophysin associated with amygdala
14) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.21 Pain Relevance 0.32
Relative to vehicle controls, naive rats given intra-LA infusion of 8-Br-cGMP prior to sacrifice at the same time as the trained animals described above exhibited no significant differences in levels of GluR1, synapsin, or synaptophysin in the LA [GluR1: t(6)?
Positive_regulation (levels) of synaptophysin associated with amygdala
15) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.15 Pain Relevance 0.31
Relative to vehicle controls, naive rats given intra-LA infusion of Y-27632 prior to sacrifice at the same time as the trained animals described above exhibited no significant differences in levels of GluR1, synapsin, or synaptophysin in the LA [GluR1: t(10)?
Positive_regulation (levels) of synaptophysin associated with amygdala
16) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.15 Pain Relevance 0.37
Relative to vehicle controls, naive rats given intra-LA infusion of 7-Ni or c-PTIO prior to sacrifice at the same time as the trained animals described above exhibited no significant differences in levels of GluR1, synapsin, or synaptophysin in the LA [GluR1: F(2,11)?
Positive_regulation (levels) of synaptophysin associated with amygdala
17) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.09 Pain Relevance 0.19
Relative to vehicle controls, naive rats given intra-LA infusion of Ifenprodil prior to sacrifice at the same time as the trained animals described above exhibited no significant differences in levels of GluR1, synapsin, or synaptophysin in the LA [GluR1: t(7)?
Positive_regulation (levels) of synaptophysin associated with amygdala
18) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.14 Pain Relevance 0.38
Relative to vehicle controls, naive rats given intra-LA infusion of Rp-8-Br-PET-cGMPS prior to sacrifice at the same time as the trained animals described above exhibited no significant differences in levels of GluR1, synapsin, or synaptophysin in the LA [GluR1: t(6)?
Positive_regulation (levels) of synaptophysin associated with amygdala
19) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.09 Pain Relevance 0.29
Similarly, fear conditioned rats exhibited significant long-lasting increases in levels of synapsin (Figure 2 d–e) and synaptophysin (Figure 2f) in the LA.
Positive_regulation (increases) of synaptophysin associated with anxiety disorder and amygdala
20) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.76 Pain Relevance 0.15

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