INT106487

Context Info Confidence 0.02 First Reported 2002 Last Reported 2002 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.74 Pain Relevance 0.04

plasma membrane (CD177, Mpl)

Anatomy Link Frequency megakaryocytes 3 CD177 (Homo sapiens) Mpl (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 1 70.08 palliative 1 25.00 pruritus 1 25.00

Disease Link Frequency Relevance Heat Erythremia 3 100.00 Erythrocytosis 1 97.30 Myelodysplastic Syndromes 3 90.72 Thrombocytosis 2 89.36 Myeloproliferative Disorder 3 87.96 Myeloid Leukemia 2 81.00 Thrombosis 1 79.52 Myeloid Metaplasia 6 78.56 Disease 4 71.56 Fibrosis 1 70.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Polycythemia vera is distinguished from reactive erythrocytosis through erythropoietin independent growth of erythroid progenitors in vitro, suppressed levels of endogenous erythropoietin, possible overexpression of PRV-1 (polycythemia rubra vera-1), decreased c-Mpl expression on megakaryocytes, as well as overexpression of bcl-xL, and potentially aberrant activity of the Jak-Stat pathway.

Spec (1061) Gene_expression (overexpression) of polycythemia rubra vera-1 in megakaryocytes Negative_regulation (decreased) of Gene_expression (expression) of c-Mpl in megakaryocytes associated with erythremia and erythrocytosis

1) Confidence 0.02 Published 2002 Journal Int. J. Hematol. Section Abstract Doc Link 12430925 Disease Relevance 1.74 Pain Relevance 0.04

General Comments

This test has worked.