INT106513

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Context Info
Confidence 0.73
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.57
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Ptges3) isomerase activity (Ptges3) protein complex (Ptges3)
cytoplasm (Ptges3) cell proliferation (Ptges3) nucleolus (Ptges3)
Anatomy Link Frequency
dorsal 1
spinal cord 1
brain 1
ventral 1
Ptges3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 42 99.18 Very High Very High Very High
Spinal cord 12 98.78 Very High Very High Very High
Pain 7 89.16 High High
Central nervous system 12 86.40 High High
intrathecal 2 81.44 Quite High
allodynia 4 78.28 Quite High
cytokine 3 78.08 Quite High
Hyperalgesia 5 77.72 Quite High
Thermal hyperalgesia 2 72.56 Quite High
corticosteroid 1 69.36 Quite High
Disease Link Frequency Relevance Heat
Shock 2 100.00 Very High Very High Very High
INFLAMMATION 46 99.18 Very High Very High Very High
Pressure And Volume Under Development 4 91.68 High High
Nociception 13 91.00 High High
Pain 4 89.16 High High
Neuropathic Pain 4 78.28 Quite High
Hyperalgesia 7 77.72 Quite High
Cancer 3 75.00 Quite High
Arthritis 3 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show by in situ hybridization and immunohistological analysis that COX-1 and cPGES are constitutively expressed in neuronal and non-neuronal cells of the dorsal and ventral horns in the spinal cord of adult rats.
Gene_expression (expressed) of cPGES in ventral associated with spinal cord
1) Confidence 0.73 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16192391 Disease Relevance 0.81 Pain Relevance 0.53
The expression of mPGES-1 was strongly up-regulated in the brain and spinal cord during inflammation, whereas no change was detected for the expression of cPGES, mPGES-2, COX-1, and terminal PGD, TX, or PGI synthases.
Gene_expression (expression) of cPGES in brain associated with inflammation and spinal cord
2) Confidence 0.60 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.46 Pain Relevance 0.44
Here we show by in situ hybridization and immunohistological analysis that COX-1 and cPGES are constitutively expressed in neuronal and non-neuronal cells of the dorsal and ventral horns in the spinal cord of adult rats.
Gene_expression (expressed) of cPGES in dorsal associated with spinal cord
3) Confidence 0.25 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16192391 Disease Relevance 0.81 Pain Relevance 0.53
The expression of mPGES-1 was strongly up-regulated in the brain and spinal cord during inflammation, whereas no change was detected for the expression of cPGES, mPGES-2, COX-1, and terminal PGD, TX, or PGI synthases.
Gene_expression (expression) of cPGES in spinal cord associated with inflammation and spinal cord
4) Confidence 0.20 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.46 Pain Relevance 0.44
Cytosolic PGES (cPGES) is constitutively expressed in a wide variety of cells and is functionally linked to COX-1 to promote immediate PGE(2) production.
Gene_expression (expressed) of cPGES
5) Confidence 0.09 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 16533161 Disease Relevance 0.23 Pain Relevance 0.11
One of its isoforms, cPGES-1, is a cytosolic protein found as a complex with heat shock protein 90 (Hsp90) that is constitutively expressed in a wide variety of cells and tissues.
Gene_expression (expressed) of cPGES-1 associated with shock
6) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.62 Pain Relevance 0.33
Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90).
Gene_expression (expressed) of cPGES associated with shock
7) Confidence 0.06 Published 2002 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 12432931 Disease Relevance 0.18 Pain Relevance 0.04

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