INT106515

Context Info Confidence 0.00 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.17 Pain Relevance 0.04

cytoplasm (Ptges, Cpox) isomerase activity (Ptges) mitochondrion (Cpox) oxidoreductase activity (Cpox) nucleus (Ptges)

Ptges (Mus musculus) Cpox (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 2 89.56 COX2 1 25.00 Pain 1 25.00

Disease Link Frequency Relevance Heat INFLAMMATION 1 89.56 Shock 1 83.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These two PGESs display distinct functional coupling with upstream COXs in cells; cPGES is predominantly coupled with the constitutive COX-1, whereas mPGES is preferentially linked with the inducible COX-2.

mPGES Binding (linked) of COX

1) Confidence 0.00 Published 2002 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 12432931 Disease Relevance 0.17 Pain Relevance 0.04

General Comments

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