INT106554

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 8
Speculated 1
Reported most in Body
Documents 73
Total Number 78
Disease Relevance 42.58
Pain Relevance 30.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 25
hippocampus 20
neuron 10
amygdala 8
PFC 7
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 837 100.00 Very High Very High Very High
amygdala 179 100.00 Very High Very High Very High
bDMF 154 100.00 Very High Very High Very High
antidepressant 1893 99.98 Very High Very High Very High
Inflammation 84 99.98 Very High Very High Very High
intrathecal 14 99.98 Very High Very High Very High
long-term potentiation 65 99.96 Very High Very High Very High
Periaqueductal grey 7 99.84 Very High Very High Very High
tricyclic antidepressant 41 99.80 Very High Very High Very High
fluoxetine 410 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 266 100.00 Very High Very High Very High
Repression 48 100.00 Very High Very High Very High
Targeted Disruption 299 99.98 Very High Very High Very High
INFLAMMATION 97 99.98 Very High Very High Very High
Aids-related Complex 134 99.96 Very High Very High Very High
Stress 598 99.84 Very High Very High Very High
Alzheimer's Dementia 158 99.72 Very High Very High Very High
Depression 2315 99.52 Very High Very High Very High
Disease 752 99.28 Very High Very High Very High
Ganglion Cysts 60 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, animal studies found that transgenic overexpression of BDNF has a facilitatory effect on anxiety-like behaviors32 and learning and memory impairments.40 A study by Zou et al.24 demonstrated that insomnia and decreased sexual desire, which are side effects of fluoxetine, may have been associated with the BDNF Val66Met polymorphism, and Met allele carriers showed a lower incidence of these adverse effects.
Positive_regulation (overexpression) of Gene_expression (overexpression) of BDNF associated with targeted disruption, hypoactive sexual desire disorder, anxiety disorder, sleep disorders and fluoxetine
1) Confidence 0.70 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.81 Pain Relevance 0.34
Specifically, we show that early-life fluoxetine exposure resulted in the long-term upregulation of BDNF expression in adult mice.
Positive_regulation (upregulation) of Gene_expression (expression) of BDNF associated with fluoxetine
2) Confidence 0.70 Published 2009 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 18973993 Disease Relevance 0.43 Pain Relevance 0.90
The synthesis of BDNF is increased in RGCs immediately after intravitreal injection of NMDA in rats [51].
Positive_regulation (increased) of Gene_expression (synthesis) of BDNF
3) Confidence 0.69 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.21 Pain Relevance 0.04
Behavioral alterations are associated with a decrease in brain-derived neurotrophic factor (BDNF) mRNA in the hippocampal dentate gyrus and fluoxetine treatment restores BDNF mRNA expression.
Positive_regulation (restores) of Gene_expression (expression) of BDNF mRNA in dentate gyrus associated with fluoxetine
4) Confidence 0.69 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18485098 Disease Relevance 0.23 Pain Relevance 0.46
Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury.
Positive_regulation (induced) of Gene_expression (expression) of BDNF gene associated with depression
5) Confidence 0.69 Published 2008 Journal J. Neurochem. Section Title Doc Link 18485098 Disease Relevance 0.27 Pain Relevance 0.32
Thus, it appears that antidepressants are effective in causing an increase in total BDNF expression in corticosterone-treated rats; however, the mechanisms for the down-regulation of BDNF transcripts by corticosterone and those that affect their upregulation by antidepressants are quite different.


Positive_regulation (increase) of Gene_expression (expression) of BDNF associated with antidepressant
6) Confidence 0.69 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.33 Pain Relevance 0.65
Altogether, these studies suggest that although BDNF expression is repressed or induced by stress or antidepressants by different mechanisms, epigenetic regulation of the BDNF gene plays an important role in depression and in the mechanisms of action of antidepressants.


Positive_regulation (induced) of Gene_expression (expression) of BDNF associated with stress, antidepressant and depression
7) Confidence 0.69 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.12 Pain Relevance 0.32
In an earlier study, Chen et al138 showed that the expression of BDNF is increased in the postmortem brain of depressed subjects treated with antidepressants compared with those who were untreated.
Positive_regulation (increased) of Gene_expression (expression) of BDNF in brain associated with antidepressant
8) Confidence 0.69 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.48 Pain Relevance 0.56
In general, an increase in BDNF expression occurs only after long-term treatment and, in most cases, short-term treatment with antidepressants causes no change in the expression of BDNF.98,101,106,117,118 However, short-term treatment with antidepressants has also been shown to cause an increase in BDNF expression in the cortex119,120 and even a decrease in the hippocampus.101,119,120
Positive_regulation (increase) of Gene_expression (expression) of BDNF in hippocampus associated with antidepressant and hippocampus
9) Confidence 0.69 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.23 Pain Relevance 0.77
Peripheral inflammation increases expression of BDNF preferentially in dorsal root ganglion cells that contain substance P and/or calcitonin gene-related peptide, known nociceptive transmitters for which synthesis is also increased during inflammatory states.
Positive_regulation (increases) of Gene_expression (expression) of BDNF in dorsal root ganglion associated with nociception, ganglion cysts, dorsal root ganglion, inflammation, calcitonin gene-related peptide and substance p
10) Confidence 0.69 Published 2002 Journal Pain Section Abstract Doc Link 12435470 Disease Relevance 0.90 Pain Relevance 0.57
Together, these data support the view that NMDA receptor antagonists enhance the potency of antidepressants, but they leave open the question as to whether enhanced BDNF expression is a necessary feature of the antidepressant-like effect.
Spec (whether) Positive_regulation (enhanced) of Spec (whether) Gene_expression (expression) of BDNF associated with antidepressant, nmda receptor antagonist and potency
11) Confidence 0.67 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16740621 Disease Relevance 0 Pain Relevance 0.50
Studies to test antidepressant response in mutant mice with Bdnf overexpression are needed.


Positive_regulation (overexpression) of Gene_expression (overexpression) of Bdnf associated with antidepressant
12) Confidence 0.61 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.36 Pain Relevance 0.68
However, music treatment could not upregulate BDNF levels in the PFC, amygdala, and hippocampus in BDNF(+/)(-) mice, which suggests the essential role of BDNF in the anxiolytic effect of music.
Neg (not) Positive_regulation (upregulate) of Gene_expression (levels) of BDNF in amygdala associated with anxiety disorder, hippocampus and amygdala
13) Confidence 0.61 Published 2010 Journal Brain Res. Section Abstract Doc Link 20515664 Disease Relevance 0.91 Pain Relevance 0.35
In general, an increase in BDNF expression occurs only after long-term treatment and, in most cases, short-term treatment with antidepressants causes no change in the expression of BDNF.98,101,106,117,118 However, short-term treatment with antidepressants has also been shown to cause an increase in BDNF expression in the cortex119,120 and even a decrease in the hippocampus.101,119,120
Positive_regulation (increase) of Gene_expression (expression) of BDNF in hippocampus associated with antidepressant and hippocampus
14) Confidence 0.60 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.15 Pain Relevance 0.93
These studies suggest that the behavioral effect of antidepressants requires TrkB activation along with an increase in BDNF expression.
Positive_regulation (increase) of Gene_expression (expression) of BDNF associated with antidepressant
15) Confidence 0.60 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.38 Pain Relevance 0.57
In general, it has been shown that when given to healthy rodents, several classes of antidepressants, including monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, tricyclic agents, noradrenaline reuptake inhibitors, and noradrenergic and specific serotonergic antidepressants, all increase expression of BDNF in the brain.98–108 In addition, several other agents known to have antidepressant properties also increase expression of BDNF in rodent brain.
Positive_regulation (increase) of Gene_expression (expression) of BDNF in brain associated with antidepressant, noradrenaline, ssri and monoamine
16) Confidence 0.60 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.41 Pain Relevance 0.69
In general, it has been shown that when given to healthy rodents, several classes of antidepressants, including monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, tricyclic agents, noradrenaline reuptake inhibitors, and noradrenergic and specific serotonergic antidepressants, all increase expression of BDNF in the brain.98–108 In addition, several other agents known to have antidepressant properties also increase expression of BDNF in rodent brain.
Positive_regulation (increase) of Gene_expression (expression) of BDNF in brain associated with antidepressant, noradrenaline, ssri and monoamine
17) Confidence 0.60 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.41 Pain Relevance 0.69
Dark-rearing is known to down-regulate BDNF-induced activation of TrkB receptors [24], despite increased BDNF protein expression [25].
Positive_regulation (increased) of Gene_expression (expression) of BDNF
18) Confidence 0.59 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2686200 Disease Relevance 0 Pain Relevance 0.05
Its expression is reduced in the VMH of lethal yellow mice, whereas administration of MTII increases BDNF expression in the VMH of wild type mice.
Positive_regulation (increases) of Gene_expression (expression) of BDNF
19) Confidence 0.57 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.43 Pain Relevance 0.07
Interestingly, the effects of visual deprivation can be readily reversed by exposure to light [4, 12] (but see [13]), and to some extent by overexpression of brain-derived neurotrophic factor (BDNF) [8].
Positive_regulation (overexpression) of Gene_expression (overexpression) of BDNF in brain
20) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2686200 Disease Relevance 0 Pain Relevance 0.25

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