INT106558

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Context Info
Confidence 0.52
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.51
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2, Ntrk3) plasma membrane (Ntrk2, Ntrk3) kinase activity (Ntrk2, Ntrk3)
cytosol (Ntrk2) cytoplasm (Ntrk3)
Ntrk2 (Mus musculus)
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 2 100.00 Very High Very High Very High
Hyperalgesia 14 99.78 Very High Very High Very High
antinociception 2 85.20 High High
nMDA receptor antagonist 2 79.28 Quite High
Inflammation 16 75.00 Quite High
intrathecal 2 68.52 Quite High
spinal dorsal horn 2 66.32 Quite High
central sensitization 2 63.04 Quite High
nMDA receptor 2 59.20 Quite High
Calcitonin gene-related peptide 2 57.72 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 18 99.78 Very High Very High Very High
Neuroblastoma 1 88.32 High High
Nociception 14 79.72 Quite High
INFLAMMATION 11 75.00 Quite High
Ganglion Cysts 4 54.92 Quite High
Pain 5 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with a trkB.FL-mediated mechanism, the i.t. administration of another trkB ligand, neurotrophin-4/5, also produces hyperalgesia while the trkC agonist neurotrophin-3, which weakly cross-reacts with trkB, has little effect.
trkB Binding (cross) of trkC associated with hyperalgesia and agonist
1) Confidence 0.52 Published 2002 Journal Pain Section Abstract Doc Link 12435470 Disease Relevance 1.17 Pain Relevance 1.14
Consistent with a trkB.FL-mediated mechanism, the i.t. administration of another trkB ligand, neurotrophin-4/5, also produces hyperalgesia while the trkC agonist neurotrophin-3, which weakly cross-reacts with trkB, has little effect.
trkB Binding (reacts) of trkC associated with hyperalgesia and agonist
2) Confidence 0.39 Published 2002 Journal Pain Section Abstract Doc Link 12435470 Disease Relevance 1.17 Pain Relevance 1.14
In biochemical studies, it was shown that Dok5 could interact specifically with TrkB and TrkC receptors, but not TrkA, and was involved in neurotrophin induced MAPK activation [20].
TrkB Binding (receptors) of TrkC
3) Confidence 0.17 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.17 Pain Relevance 0

General Comments

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