INT106595

From wiki-pain
Revision as of 00:28, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.15
Pain Relevance 9.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dnm2) cytoskeleton (Dnm2) nucleus (Dnm2)
GTPase activity (Dnm2) protein complex (Dnm2) cytoplasm (Dnm2)
Anatomy Link Frequency
spinal cords 2
Dnm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 20 99.90 Very High Very High Very High
opioid receptor 36 99.48 Very High Very High Very High
narcan 21 99.04 Very High Very High Very High
Immobilon 37 97.40 Very High Very High Very High
mu opioid receptor 16 96.56 Very High Very High Very High
tail-flick 3 96.28 Very High Very High Very High
Morphine 30 95.20 Very High Very High Very High
antagonist 28 94.24 High High
Opioid 21 93.76 High High
MU agonist 14 90.16 High High
Disease Link Frequency Relevance Heat
Convulsion 34 53.24 Quite High
Hearing Impairment 4 51.08 Quite High
Ataxia 7 50.52 Quite High
Epilepsy 15 50.00 Quite Low
Generalized Epilepsy 3 39.84 Quite Low
Congenital Anomalies 4 36.28 Quite Low
Neurological Disease 4 26.24 Quite Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Higher infusion doses significantly down-regulated muOR density, increased DYN-2 protein abundance, and decreased DYN-2 mRNA.
Negative_regulation (decreased) of DYN-2 mRNA
1) Confidence 0.58 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.88
Finally, the decrease in DYN-2 mRNA may be related to stabilization of DYN-2 protein abundance, which might inhibit transcription.
Negative_regulation (decrease) of DYN-2 mRNA
2) Confidence 0.57 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435815 Disease Relevance 0 Pain Relevance 1.06
At 192 h following 8-day NTX treatment, GRK-2 protein and mRNA were at control levels, while DYN-2 protein remained decreased (-31%) even though DYN-2 mRNA had returned to control levels.
Negative_regulation (decreased) of DYN-2 protein
3) Confidence 0.54 Published 2003 Journal Synapse Section Abstract Doc Link 12872295 Disease Relevance 0 Pain Relevance 0.81
Second, assembly of non-functional DNM2 and DNM1aFtfl heterodimers could inhibit proper DNM2 function.
Negative_regulation (inhibit) of DNM2
4) Confidence 0.46 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.15 Pain Relevance 0
Finally, the decrease in DYN-2 mRNA may be related to stabilization of DYN-2 protein abundance, which might inhibit transcription.
Negative_regulation (stabilization) of DYN-2 protein
5) Confidence 0.41 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435815 Disease Relevance 0 Pain Relevance 1.04
The increases in mu-receptor density were proportional to dose-dependent decreases in GRK-2 and DYN-2 protein levels.
Negative_regulation (decreases) of DYN-2 protein
6) Confidence 0.39 Published 2003 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12957235 Disease Relevance 0 Pain Relevance 1.16
Mu-opioid receptor up-regulation has been associated with decreases in the trafficking protein dynamin-2, whereas mu-opioid receptor down-regulation produces an increase in dynamin-2 abundance.
Negative_regulation (decreases) of dynamin-2 associated with opioid receptor
7) Confidence 0.38 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.22
In previous studies, naltrexone treatment produced an increase in muOR density accompanied by decreases in GRK-2 and DYN-2 protein abundance.
Negative_regulation (decreases) of DYN-2 protein
8) Confidence 0.29 Published 2003 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12957235 Disease Relevance 0 Pain Relevance 0.68
Continuous (7-8 days) s.c. infusions of naloxone (5 mg/kg/day) or naltrexone (15 mg s.c. implant pellet) increased mu-opioid receptor density in radioligand binding assays (approximately +80%) in mouse spinal cord and down-regulated dynamin-2 abundance (approximately -30%), but had no effect on the abundance of immunoreactive mu-opioid receptor.
Negative_regulation (down-regulated) of dynamin-2 in spinal cord associated with narcan, opioid receptor and spinal cord
9) Confidence 0.28 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.32
Other mice were sacrificed at the end of the treatment and spinal cords were collected for determination of muOR density and GRK-2 and DYN-2 protein abundance.
Negative_regulation (determination) of DYN-2 protein in spinal cords
10) Confidence 0.13 Published 2003 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12957235 Disease Relevance 0 Pain Relevance 1.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox