INT106630

Context Info Confidence 0.16 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.82 Pain Relevance 0.19

cytoplasm (GRK5, PRKCA) signal transduction (GRK5, PRKCA) nucleus (GRK5, PRKCA) plasma membrane (GRK5, PRKCA) nucleoplasm (PRKCA) mitochondrion (PRKCA)

GRK5 (Homo sapiens) PRKCA (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 4 99.60 Dismenorea 1 93.08 antagonist 2 46.64

Disease Link Frequency Relevance Heat Ocular Hypertension 1 94.08 Reprotox - General 1 1 93.08 Disorder Of Lipid Metabolism 1 92.52 Cirrhosis 1 91.72 Pressure And Volume Under Development 1 91.04 Heart Rate Under Development 1 90.12 Hyponatremia 1 89.04 Syndrome 1 87.40 Neurogenic Diabetes Insipidus 1 86.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

By immunoprecipitation and immunoblotting, we elucidated the phosphorylation pattern of green fluorescent protein-tagged AVP receptors and showed interactions with the specific kinases PKC and GRK5 that are agonist-, time- and receptor subtype-dependent.

GRK5 Binding (interactions) of PKC associated with agonist

1) Confidence 0.16 Published 2002 Journal Prog. Brain Res. Section Abstract Doc Link 12436935 Disease Relevance 0.82 Pain Relevance 0.19

General Comments

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