INT106668

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Context Info
Confidence 0.10
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.93
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NDRG1) plasma membrane (NDRG1) nucleus (NDRG1)
cytoplasm (NDRG1)
Anatomy Link Frequency
neuronal 2
pancreas 2
neurons 2
NDRG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 37 100.00 Very High Very High Very High
Spinal cord 16 100.00 Very High Very High Very High
sodium channel 3 100.00 Very High Very High Very High
nav1.8 3 100.00 Very High Very High Very High
Congenital analgesia 1 99.44 Very High Very High Very High
Nav1.7 6 99.16 Very High Very High Very High
hyperexcitability 2 98.20 Very High Very High Very High
Pain 40 96.16 Very High Very High Very High
withdrawal 5 85.56 High High
tolerance 13 82.28 Quite High
Disease Link Frequency Relevance Heat
Congenital Pain Insensitivity 1 99.44 Very High Very High Very High
Cold Sores 109 99.32 Very High Very High Very High
Nociception 19 97.84 Very High Very High Very High
Syndrome 2 96.56 Very High Very High Very High
Pain 47 96.16 Very High Very High Very High
Herpes Simplex Virus 5 94.08 High High
Hypersensitivity 8 88.36 High High
Pancreatitis 56 82.88 Quite High
Infection 3 60.08 Quite High
INFLAMMATION 51 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of sodium channel Nav1.8 in DRG neurons has also been shown to be essential for the manifestation of mutant Nav1.7-induced neuronal hyperexcitability.
Positive_regulation (essential) of Gene_expression (Expression) of DRG in neuronal associated with sodium channel, nav1.8, hyperexcitability and nav1.7
1) Confidence 0.10 Published 2010 Journal Mol Pain Section Abstract Doc Link 20529343 Disease Relevance 0.65 Pain Relevance 1.41
Delivery of recombinant viruses to the skin of mice results in expression of encoded complementary DNA (cDNA) genes in DRG neurons within three to four days.
Positive_regulation (results) of Gene_expression (expression) of DRG in neurons
2) Confidence 0.02 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12438172 Disease Relevance 0.42 Pain Relevance 0.50
Increased met-Enkephalin (met-ENK) expression in spinal cord, DRG and pancreas in HSV-ENK-treated animals
Positive_regulation (Increased) of Gene_expression (expression) of DRG in pancreas associated with cold sores, enkephalin and spinal cord
3) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2292157 Disease Relevance 0.87 Pain Relevance 0.57

General Comments

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