INT106676

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| style="color: black; background:#AAFCFB; white-space:wrap;"| '''Pain Relations:'''
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Pain Term
(frequency)
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Transient receptor potential channels]] (8)
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Confidence
{{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Persistent pain]] (12)
+
|-
{{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[TRP channel]]
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[burning pain]] (1)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 8
{{#icon: chilli.png|Quite High}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[inflammatory pain]] (10)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
{{#icon: chilli.png|Quite High}}
+
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Local anesthetics]] (1)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Lasting pain]]
{{#icon: chilli.png|Quite High}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 12
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[potassium channels]] (1)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 99.44
{{#icon: chilli.png|Quite High}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[burning pain]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 84.8
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[IPN]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 10
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 80.96
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[local anesthetic]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 78.32
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[potassium channel]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 77.28
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[antagonist]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 60
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 76.48
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Cancer pain]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 75.76
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Substantia gelatinosa neuron]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 75
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[intrathecal]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 55
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 61.76
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
|-
 
|-
| style="color: black; background:#AAFCFB; white-space:wrap;"| '''Disease Relations:'''
 
(frequency)
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Inflammatory Pain]] (10)
 
{{#icon: chilli.png|Quite High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Metastasis]] (4)
 
{{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Toxicity]] (1)
 
{{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Malignant Neoplastic Disease]] (4)
 
{{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Hyperalgesia]] (102)
 
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Respiratory Failure]] (4)
 
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
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|-
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+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Disease Term
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Confidence
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 
|-
 
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Inflammatory Pain]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 10
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 80.96
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Metastasis]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 4
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 23.12
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Toxicity]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 18
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Malignant Neoplastic Disease]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 4
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 9.92
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Hyperalgesia]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 102
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Respiratory Failure]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 4
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Sleep Disorders]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Death]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 8
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Nociception]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 76
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Depression]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 10
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
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Revision as of 12:15, 12 September 2012

Context Info
Confidence 1.6114138100
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in NULL
Documents 18
Total Number 18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) cytosol (Trpv1) RNA binding (Phax)
nucleus (Phax) plasma membrane (Trpv1) cytoplasm (Phax)
Anatomy Mention Frequency
neurons 3
spinal cord 1
paw 1
Trpv1 (Rattus norvegicus)
Phax (Rattus norvegicus)
Pain Term Frequency Confidence Heat
TRP channel 8 100 Very High Very High Very High
Lasting pain 12 99.44 Very High Very High Very High
burning pain 1 84.8 Quite High
IPN 10 80.96 Quite High
local anesthetic 1 78.32 Quite High
potassium channel 1 77.28 Quite High
antagonist 60 76.48 Quite High
Cancer pain 2 75.76 Quite High
Substantia gelatinosa neuron 1 75 Quite High
intrathecal 55 61.76 Quite High
|
Disease Term Frequency Confidence Heat
Inflammatory Pain 10 80.96 Quite High
Metastasis 4 23.12 Low Low
Toxicity 1 18 Low Low
Malignant Neoplastic Disease 4 9.92 Low Low
Hyperalgesia 102 5 Very Low Very Low Very Low
Respiratory Failure 4 5 Very Low Very Low Very Low
Sleep Disorders 2 5 Very Low Very Low Very Low
Death 8 5 Very Low Very Low Very Low
Nociception 76 5 Very Low Very Low Very Low
Depression 10 5 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Event Anatomy Negation Speculation Pain term
Resiniferatoxin (RTX) has a much higher affinity for TRPV1 than capsaicin, but its ability to modulate excitatory transmission is unclear.
TRPV1 Binding (affinity) of RTX
1) Confidence 0.337430605132486 Published 2009 Journal N/A Section N/A Doc Link 19778582
Despite this activity and the high affinity of I-RTX for rat TRPV1, only capsazepine proved to be an effective antagonist of capsaicin-induced paw flinching in rats.
TRPV1 Binding (affinity) of RTX in paw
2) Confidence 0.259168494995643 Published 2002 Journal N/A Section N/A Doc Link 12438527
The binding of RTX leads to a sustained influx of sodium and calcium through TRPV1 channels [12] leading to channel desensitization and/or the loss of TRPV1-expressing DRG neurons and/or their fibers and terminals via calcium-induced cytotoxicity [13,14].
TRPV1 Binding (binding) of RTX in neurons
3) Confidence 0.114684148096938 Published 2010 Journal N/A Section N/A Doc Link PMC3019206
Resiniferatoxin (RTX), an ultrapotent capsaicin analog, is a vanilloid agonist that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1), a non-selective cation ion channel expressed in small- and medium-sized neurons in sensory ganglia [1-3].
vanilloid subfamily member 1 Binding (binds) of RTX in neurons
4) Confidence 0.111562652152031 Published 2008 Journal N/A Section N/A Doc Link PMC2242785
Resiniferatoxin (RTX), an ultrapotent capsaicin analog, is a vanilloid agonist that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1), a non-selective cation ion channel expressed in small- and medium-sized neurons in sensory ganglia [1-3].
TRPV1 Binding (binds) of RTX in neurons
5) Confidence 0.111562652152031 Published 2008 Journal N/A Section N/A Doc Link PMC2242785
These studies suggest that RTX binds to TRPV1 with high affinity and does not readily desensitize the receptor.
TRPV1 Binding (binds) of RTX
6) Confidence 0.0952481281773539 Published 2009 Journal N/A Section N/A Doc Link PMC2737142
Since RTX binds to TRPV1 irreversibly and with high affinity, we propose this property will aid in its localization in a given segment of the spinal cord by slow infusion using osmotic mini pumps.
TRPV1 Binding (binds) of RTX in spinal cord
7) Confidence 0.0952481281773539 Published 2009 Journal N/A Section N/A Doc Link PMC2737142
Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia

Resiniferatoxin (RTX) is an ultrapotent capsaicin analog that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1).

TRPV1 Binding (binds) of RTX
8) Confidence 0.0829568439079204 Published 2008 Journal N/A Section N/A Doc Link PMC2242785
Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia

Resiniferatoxin (RTX) is an ultrapotent capsaicin analog that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1).

vanilloid subfamily member 1 Binding (binds) of RTX
9) Confidence 0.0829568439079204 Published 2008 Journal N/A Section N/A Doc Link PMC2242785
Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain.
TRPV1 Binding (binds) of Resiniferatoxin
10) Confidence 0.0484003589688347 Published 2004 Journal N/A Section N/A Doc Link 14992587
Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain.
capsaicin receptor Binding (binds) of Resiniferatoxin
11) Confidence 0.0484003589688347 Published 2004 Journal N/A Section N/A Doc Link 14992587
Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both bind with higher affinity to the rat TRPV1 (rTRPV1) than the human (hTRPV1) isoform.
TRPV1 Binding (bind) of Resiniferatoxin
12) Confidence 0.0359900105152873 Published 2004 Journal N/A Section N/A Doc Link 14992587
Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both bind with higher affinity to the rat TRPV1 (rTRPV1) than the human (hTRPV1) isoform.
TRPV1 Binding (bind) of RTX
13) Confidence 0.0359900105152873 Published 2004 Journal N/A Section N/A Doc Link 14992587
Interestingly, RTX, a high affinity ligand for VR1, did alter regularly discharging BRs even at higher relative concentrations [20].
VR1 Binding (ligand) of RTX
14) Confidence 0.0343193927387091 Published 2006 Journal N/A Section N/A Doc Link PMC1481593
Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both bind with higher affinity to the rat TRPV1 (rTRPV1) than the human (hTRPV1) isoform.
rTRPV1 Binding (bind) of Resiniferatoxin
15) Confidence 0.0313825937101902 Published 2004 Journal N/A Section N/A Doc Link 14992587
Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both bind with higher affinity to the rat TRPV1 (rTRPV1) than the human (hTRPV1) isoform.
TRPV1 Binding (bind) of RTX
16) Confidence 0.0313825937101902 Published 2004 Journal N/A Section N/A Doc Link 14992587
To identify the structural features responsible for this difference in affinity, [(3)H]RTX binding to chimeras between hTRPV1 and rTRPV1 was characterized.
rTRPV1 Binding (binding) of RTX
17) Confidence 0.0273650152883542 Published 2004 Journal N/A Section N/A Doc Link 14992587
Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both bind with higher affinity to the rat TRPV1 (rTRPV1) than the human (hTRPV1) isoform.
rTRPV1 Binding (bind) of RTX
18) Confidence 0.0273650152883542 Published 2004 Journal N/A Section N/A Doc Link 14992587

General Comments

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