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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Disease Relevance
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 4.19408
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 4.19
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Pain Relevance
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 16.18456
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 12.36
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[antagonist]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[antagonist]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 60
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 60
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[TRP channel]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[TRP channel]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 8
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 8
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[qutenza]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[qutenza]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 231
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 231
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
|-
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[agonist]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[agonist]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 60
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 60
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Action potential]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Action potential]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 17
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 17
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 98.2
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 98.20
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
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{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Resiniferatoxin (<span style="background-color:#FFFF00">RTX</span>) has a much higher <span style="background-color:#B0E0E6">affinity</span> for <span style="background-color:#FFFF00">TRPV1</span> than capsaicin, but its ability to modulate excitatory transmission is unclear.  
+
| Resiniferatoxin (<span style="background-color:#FFFF00">RTX</span>) has a much higher <span style="background-color:#B0E0E6">affinity</span> for <span style="background-color:#FFFF00">TRPV1</span> than <span style="background-color:#FFA07A">capsaicin</span>, but its ability to modulate excitatory transmission is unclear.  
 
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{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
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| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">affinity</span>) of <span style="color:#800000">'''RTX'''</span>
+
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">affinity</span>) of <span style="color:#800000">'''RTX'''</span> associated with <span style="color:#FF0000">'''qutenza'''</span>
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=19778582 19778582]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=19778582 19778582]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.50
 
|}
 
|}
 
|-
 
|-
 
|}
 
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{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Despite this activity and the high <span style="background-color:#B0E0E6">affinity</span> of I-<span style="background-color:#FFFF00">RTX</span> for rat <span style="background-color:#FFFF00">TRPV1</span>, only capsazepine proved to be an effective antagonist of capsaicin-induced <span style="background-color:#FFDEAD">paw</span> flinching in rats.  
+
| Despite this activity and the high <span style="background-color:#B0E0E6">affinity</span> of I-<span style="background-color:#FFFF00">RTX</span> for rat <span style="background-color:#FFFF00">TRPV1</span>, only capsazepine proved to be an effective <span style="background-color:#FFA07A">antagonist</span> of <span style="background-color:#FFA07A">capsaicin</span>-induced <span style="background-color:#FFDEAD">paw</span> flinching in rats.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">affinity</span>) of <span style="color:#800000">'''RTX'''</span> in <span style="color:#808000">paw</span>
+
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">affinity</span>) of <span style="color:#800000">'''RTX'''</span> in <span style="color:#808000">paw</span> associated with <span style="color:#FF0000">'''qutenza'''</span> and <span style="color:#FF0000">'''antagonist'''</span>
 
|-
 
|-
 
|}
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=12438527 12438527]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=12438527 12438527]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.06
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.53
 
|}
 
|}
 
|-
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC3019206 PMC3019206]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC3019206 PMC3019206]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.57
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.40
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Resiniferatoxin (<span style="background-color:#FFFF00">RTX</span>), an ultrapotent capsaicin analog, is a vanilloid agonist that <span style="background-color:#B0E0E6">binds</span> to the transient receptor potential channel, <span style="background-color:#FFFF00">vanilloid subfamily member 1</span> (TRPV1), a non-selective cation ion channel expressed in small- and medium-sized <span style="background-color:#FFDEAD">neurons</span> in sensory ganglia [1-3].  
+
| Resiniferatoxin (<span style="background-color:#FFFF00">RTX</span>), an ultrapotent <span style="background-color:#FFA07A">capsaicin</span> analog, is a vanilloid <span style="background-color:#FFA07A">agonist</span> that <span style="background-color:#B0E0E6">binds</span> to the <span style="background-color:#FFA07A">transient receptor potential channel</span>, <span style="background-color:#FFFF00">vanilloid subfamily member 1</span> (TRPV1), a non-selective cation ion channel expressed in small- and medium-sized <span style="background-color:#FFDEAD">neurons</span> in sensory ganglia [1-3].  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''vanilloid subfamily member 1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''RTX'''</span> in <span style="color:#808000">neurons</span>
+
| <span style="color:#800000">'''vanilloid subfamily member 1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''RTX'''</span> in <span style="color:#808000">neurons</span> associated with <span style="color:#FF0000">'''trp channel'''</span>, <span style="color:#FF0000">'''qutenza'''</span> and <span style="color:#FF0000">'''agonist'''</span>
 
|-
 
|-
 
|}
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2242785 PMC2242785]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2242785 PMC2242785]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.48
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.57
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Resiniferatoxin (<span style="background-color:#FFFF00">RTX</span>), an ultrapotent capsaicin analog, is a vanilloid agonist that <span style="background-color:#B0E0E6">binds</span> to the transient receptor potential channel, vanilloid subfamily member 1 (<span style="background-color:#FFFF00">TRPV1</span>), a non-selective cation ion channel expressed in small- and medium-sized <span style="background-color:#FFDEAD">neurons</span> in sensory ganglia [1-3].  
+
| Resiniferatoxin (<span style="background-color:#FFFF00">RTX</span>), an ultrapotent <span style="background-color:#FFA07A">capsaicin</span> analog, is a vanilloid <span style="background-color:#FFA07A">agonist</span> that <span style="background-color:#B0E0E6">binds</span> to the <span style="background-color:#FFA07A">transient receptor potential channel</span>, vanilloid subfamily member 1 (<span style="background-color:#FFFF00">TRPV1</span>), a non-selective cation ion channel expressed in small- and medium-sized <span style="background-color:#FFDEAD">neurons</span> in sensory ganglia [1-3].  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''RTX'''</span> in <span style="color:#808000">neurons</span>
+
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''RTX'''</span> in <span style="color:#808000">neurons</span> associated with <span style="color:#FF0000">'''trp channel'''</span>, <span style="color:#FF0000">'''qutenza'''</span> and <span style="color:#FF0000">'''agonist'''</span>
 
|-
 
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|}
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2242785 PMC2242785]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2242785 PMC2242785]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.49
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.57
 
|}
 
|}
 
|-
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2737142 PMC2737142]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2737142 PMC2737142]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.49
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.97
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Since <span style="background-color:#FFFF00">RTX</span> <span style="background-color:#B0E0E6">binds</span> to <span style="background-color:#FFFF00">TRPV1</span> irreversibly and with high affinity, we propose this property will aid in its localization in a given segment of the <span style="background-color:#FFDEAD">spinal cord</span> by slow infusion using osmotic mini pumps.  
+
| Since <span style="background-color:#FFFF00">RTX</span> <span style="background-color:#B0E0E6">binds</span> to <span style="background-color:#FFFF00">TRPV1</span> irreversibly and with high affinity, we propose this property will aid in its localization in a given segment of the <span style="background-color:#FFA07A">spinal cord</span> by slow infusion using osmotic mini pumps.  
 
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|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''RTX'''</span> in <span style="color:#808000">spinal cord</span>
+
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''RTX'''</span> in <span style="color:#808000">spinal cord</span> associated with <span style="color:#FF0000">'''spinal cord'''</span>
 
|-
 
|-
 
|}
 
|}
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2737142 PMC2737142]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2737142 PMC2737142]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.27
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.68
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia
+
| Perineural resiniferatoxin selectively inhibits <span style="background-color:#FFA07A">inflammatory</span> <span style="background-color:#FFA07A">hyperalgesia</span>
  
Resiniferatoxin (<span style="background-color:#FFFF00">RTX</span>) is an ultrapotent capsaicin analog that <span style="background-color:#B0E0E6">binds</span> to the transient receptor potential channel, vanilloid subfamily member 1 (<span style="background-color:#FFFF00">TRPV1</span>).  
+
Resiniferatoxin (<span style="background-color:#FFFF00">RTX</span>) is an ultrapotent <span style="background-color:#FFA07A">capsaicin</span> analog that <span style="background-color:#B0E0E6">binds</span> to the <span style="background-color:#FFA07A">transient receptor potential channel</span>, vanilloid subfamily member 1 (<span style="background-color:#FFFF00">TRPV1</span>).  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''RTX'''</span>
+
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''RTX'''</span> associated with <span style="color:#FF0000">'''hyperalgesia'''</span>, <span style="color:#FF0000">'''trp channel'''</span>, <span style="color:#FF0000">'''qutenza'''</span> and <span style="color:#FF0000">'''inflammation'''</span>
 
|-
 
|-
 
|}
 
|}
Line 497: Line 497:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2242785 PMC2242785]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2242785 PMC2242785]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.92
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.61
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia
+
| Perineural resiniferatoxin selectively inhibits <span style="background-color:#FFA07A">inflammatory</span> <span style="background-color:#FFA07A">hyperalgesia</span>
  
Resiniferatoxin (<span style="background-color:#FFFF00">RTX</span>) is an ultrapotent capsaicin analog that <span style="background-color:#B0E0E6">binds</span> to the transient receptor potential channel, <span style="background-color:#FFFF00">vanilloid subfamily member 1</span> (TRPV1).  
+
Resiniferatoxin (<span style="background-color:#FFFF00">RTX</span>) is an ultrapotent <span style="background-color:#FFA07A">capsaicin</span> analog that <span style="background-color:#B0E0E6">binds</span> to the <span style="background-color:#FFA07A">transient receptor potential channel</span>, <span style="background-color:#FFFF00">vanilloid subfamily member 1</span> (TRPV1).  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''vanilloid subfamily member 1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''RTX'''</span>
+
| <span style="color:#800000">'''vanilloid subfamily member 1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''RTX'''</span> associated with <span style="color:#FF0000">'''hyperalgesia'''</span>, <span style="color:#FF0000">'''trp channel'''</span>, <span style="color:#FF0000">'''qutenza'''</span> and <span style="color:#FF0000">'''inflammation'''</span>
 
|-
 
|-
 
|}
 
|}
Line 530: Line 530:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2242785 PMC2242785]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2242785 PMC2242785]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.92
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.61
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| <span style="background-color:#FFFF00">Resiniferatoxin</span> <span style="background-color:#B0E0E6">binds</span> to the capsaicin receptor (<span style="background-color:#FFFF00">TRPV1</span>) near the extracellular side of the S4 transmembrane domain.
+
| <span style="background-color:#FFFF00">Resiniferatoxin</span> <span style="background-color:#B0E0E6">binds</span> to the <span style="background-color:#FFA07A">capsaicin</span> receptor (<span style="background-color:#FFFF00">TRPV1</span>) near the extracellular side of the S4 transmembrane domain.
  
 
|-
 
|-
Line 543: Line 543:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''Resiniferatoxin'''</span>
+
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''Resiniferatoxin'''</span> associated with <span style="color:#FF0000">'''qutenza'''</span>
 
|-
 
|-
 
|}
 
|}
Line 562: Line 562:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.76
 
|}
 
|}
 
|-
 
|-
Line 575: Line 575:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''capsaicin receptor'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''Resiniferatoxin'''</span>
+
| <span style="color:#800000">'''capsaicin receptor'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binds</span>) of <span style="color:#800000">'''Resiniferatoxin'''</span> associated with <span style="color:#FF0000">'''qutenza'''</span>
 
|-
 
|-
 
|}
 
|}
Line 594: Line 594:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.76
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| <span style="background-color:#FFFF00">Resiniferatoxin</span> (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both <span style="background-color:#B0E0E6">bind</span> with higher affinity to the rat <span style="background-color:#FFFF00">TRPV1</span> (rTRPV1) than the human (hTRPV1) isoform.  
+
| <span style="background-color:#FFFF00">Resiniferatoxin</span> (RTX), a potent <span style="background-color:#FFA07A">agonist</span> of TRPV1, and iodoresiniferatoxin (I-RTX), a potent <span style="background-color:#FFA07A">antagonist</span> of TRPV1, both <span style="background-color:#B0E0E6">bind</span> with higher affinity to the rat <span style="background-color:#FFFF00">TRPV1</span> (rTRPV1) than the human (hTRPV1) isoform.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">bind</span>) of <span style="color:#800000">'''Resiniferatoxin'''</span>
+
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">bind</span>) of <span style="color:#800000">'''Resiniferatoxin'''</span> associated with <span style="color:#FF0000">'''antagonist'''</span> and <span style="color:#FF0000">'''agonist'''</span>
 
|-
 
|-
 
|}
 
|}
Line 625: Line 625:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.61
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Resiniferatoxin (<span style="background-color:#FFFF00">RTX</span>), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both <span style="background-color:#B0E0E6">bind</span> with higher affinity to the rat <span style="background-color:#FFFF00">TRPV1</span> (rTRPV1) than the human (hTRPV1) isoform.  
+
| Resiniferatoxin (<span style="background-color:#FFFF00">RTX</span>), a potent <span style="background-color:#FFA07A">agonist</span> of TRPV1, and iodoresiniferatoxin (I-RTX), a potent <span style="background-color:#FFA07A">antagonist</span> of TRPV1, both <span style="background-color:#B0E0E6">bind</span> with higher affinity to the rat <span style="background-color:#FFFF00">TRPV1</span> (rTRPV1) than the human (hTRPV1) isoform.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">bind</span>) of <span style="color:#800000">'''RTX'''</span>
+
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">bind</span>) of <span style="color:#800000">'''RTX'''</span> associated with <span style="color:#FF0000">'''antagonist'''</span> and <span style="color:#FF0000">'''agonist'''</span>
 
|-
 
|-
 
|}
 
|}
Line 656: Line 656:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.60
 
|}
 
|}
 
|-
 
|-
Line 687: Line 687:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC1481593 PMC1481593]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC1481593 PMC1481593]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.79
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| <span style="background-color:#FFFF00">Resiniferatoxin</span> (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both <span style="background-color:#B0E0E6">bind</span> with higher affinity to the rat TRPV1 (<span style="background-color:#FFFF00">rTRPV1</span>) than the human (hTRPV1) isoform.  
+
| <span style="background-color:#FFFF00">Resiniferatoxin</span> (RTX), a potent <span style="background-color:#FFA07A">agonist</span> of TRPV1, and iodoresiniferatoxin (I-RTX), a potent <span style="background-color:#FFA07A">antagonist</span> of TRPV1, both <span style="background-color:#B0E0E6">bind</span> with higher affinity to the rat TRPV1 (<span style="background-color:#FFFF00">rTRPV1</span>) than the human (hTRPV1) isoform.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''rTRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">bind</span>) of <span style="color:#800000">'''Resiniferatoxin'''</span>
+
| <span style="color:#800000">'''rTRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">bind</span>) of <span style="color:#800000">'''Resiniferatoxin'''</span> associated with <span style="color:#FF0000">'''antagonist'''</span> and <span style="color:#FF0000">'''agonist'''</span>
 
|-
 
|-
 
|}
 
|}
Line 718: Line 718:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.61
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-<span style="background-color:#FFFF00">RTX</span>), a potent antagonist of TRPV1, both <span style="background-color:#B0E0E6">bind</span> with higher affinity to the rat <span style="background-color:#FFFF00">TRPV1</span> (rTRPV1) than the human (hTRPV1) isoform.  
+
| Resiniferatoxin (RTX), a potent <span style="background-color:#FFA07A">agonist</span> of TRPV1, and iodoresiniferatoxin (I-<span style="background-color:#FFFF00">RTX</span>), a potent <span style="background-color:#FFA07A">antagonist</span> of TRPV1, both <span style="background-color:#B0E0E6">bind</span> with higher affinity to the rat <span style="background-color:#FFFF00">TRPV1</span> (rTRPV1) than the human (hTRPV1) isoform.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">bind</span>) of <span style="color:#800000">'''RTX'''</span>
+
| <span style="color:#800000">'''TRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">bind</span>) of <span style="color:#800000">'''RTX'''</span> associated with <span style="color:#FF0000">'''antagonist'''</span> and <span style="color:#FF0000">'''agonist'''</span>
 
|-
 
|-
 
|}
 
|}
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.59
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.61
 
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{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-<span style="background-color:#FFFF00">RTX</span>), a potent antagonist of TRPV1, both <span style="background-color:#B0E0E6">bind</span> with higher affinity to the rat TRPV1 (<span style="background-color:#FFFF00">rTRPV1</span>) than the human (hTRPV1) isoform.  
+
| Resiniferatoxin (RTX), a potent <span style="background-color:#FFA07A">agonist</span> of TRPV1, and iodoresiniferatoxin (I-<span style="background-color:#FFFF00">RTX</span>), a potent <span style="background-color:#FFA07A">antagonist</span> of TRPV1, both <span style="background-color:#B0E0E6">bind</span> with higher affinity to the rat TRPV1 (<span style="background-color:#FFFF00">rTRPV1</span>) than the human (hTRPV1) isoform.  
 
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{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
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| <span style="color:#800000">'''rTRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">bind</span>) of <span style="color:#800000">'''RTX'''</span>
+
| <span style="color:#800000">'''rTRPV1'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">bind</span>) of <span style="color:#800000">'''RTX'''</span> associated with <span style="color:#FF0000">'''antagonist'''</span> and <span style="color:#FF0000">'''agonist'''</span>
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=14992587 14992587]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.59
 
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Revision as of 13:30, 14 September 2012

Context Info
Confidence 0.34
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 4.19
Pain Relevance 12.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) cytosol (Trpv1) RNA binding (Phax)
nucleus (Phax) plasma membrane (Trpv1) cytoplasm (Phax)
Anatomy Mention Frequency
neurons 3
spinal cord 1
paw 1
Trpv1 (Rattus norvegicus)
Phax (Rattus norvegicus)
Pain Term Frequency Confidence Heat
antagonist 60 100.00 Very High Very High Very High
TRP channel 8 100.00 Very High Very High Very High
qutenza 231 100.00 Very High Very High Very High
agonist 60 100.00 Very High Very High Very High
Hyperalgesia 82 99.62 Very High Very High Very High
Analgesic 44 99.52 Very High Very High Very High
Lasting pain 12 99.44 Very High Very High Very High
Inflammation 265 99.36 Very High Very High Very High
Action potential 17 98.20 Very High Very High Very High
IPN 10 97.24 Very High Very High Very High
Disease Term Frequency Confidence Heat
Hyperalgesia 102 99.62 Very High Very High Very High
Pain 109 99.44 Very High Very High Very High
INFLAMMATION 245 99.36 Very High Very High Very High
Inflammatory Pain 10 97.24 Very High Very High Very High
Neuropathic Pain 11 96.36 Very High Very High Very High
Nociception 76 86.84 High High
Bone Cancer 6 76.16 Quite High
Ganglion Cysts 56 72.64 Quite High
Overactive Bladder 2 65.68 Quite High
Abnormal Reflex 2 56.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resiniferatoxin (RTX) has a much higher affinity for TRPV1 than capsaicin, but its ability to modulate excitatory transmission is unclear.
TRPV1 Binding (affinity) of RTX associated with qutenza
1) Confidence 0.34 Published 2009 Journal Neuroscience Section Abstract Doc Link 19778582 Disease Relevance 0 Pain Relevance 0.50
Despite this activity and the high affinity of I-RTX for rat TRPV1, only capsazepine proved to be an effective antagonist of capsaicin-induced paw flinching in rats.
TRPV1 Binding (affinity) of RTX in paw associated with qutenza and antagonist
2) Confidence 0.26 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438527 Disease Relevance 0.06 Pain Relevance 0.53
The binding of RTX leads to a sustained influx of sodium and calcium through TRPV1 channels [12] leading to channel desensitization and/or the loss of TRPV1-expressing DRG neurons and/or their fibers and terminals via calcium-induced cytotoxicity [13,14].
TRPV1 Binding (binding) of RTX in neurons
3) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.57 Pain Relevance 1.40
Resiniferatoxin (RTX), an ultrapotent capsaicin analog, is a vanilloid agonist that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1), a non-selective cation ion channel expressed in small- and medium-sized neurons in sensory ganglia [1-3].
vanilloid subfamily member 1 Binding (binds) of RTX in neurons associated with trp channel, qutenza and agonist
4) Confidence 0.11 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242785 Disease Relevance 0.48 Pain Relevance 0.57
Resiniferatoxin (RTX), an ultrapotent capsaicin analog, is a vanilloid agonist that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1), a non-selective cation ion channel expressed in small- and medium-sized neurons in sensory ganglia [1-3].
TRPV1 Binding (binds) of RTX in neurons associated with trp channel, qutenza and agonist
5) Confidence 0.11 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242785 Disease Relevance 0.49 Pain Relevance 0.57
These studies suggest that RTX binds to TRPV1 with high affinity and does not readily desensitize the receptor.
TRPV1 Binding (binds) of RTX
6) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.49 Pain Relevance 0.97
Since RTX binds to TRPV1 irreversibly and with high affinity, we propose this property will aid in its localization in a given segment of the spinal cord by slow infusion using osmotic mini pumps.
TRPV1 Binding (binds) of RTX in spinal cord associated with spinal cord
7) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.27 Pain Relevance 0.68
Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia

Resiniferatoxin (RTX) is an ultrapotent capsaicin analog that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1).

TRPV1 Binding (binds) of RTX associated with hyperalgesia, trp channel, qutenza and inflammation
8) Confidence 0.08 Published 2008 Journal Mol Pain Section Title Doc Link PMC2242785 Disease Relevance 0.92 Pain Relevance 0.61
Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia

Resiniferatoxin (RTX) is an ultrapotent capsaicin analog that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1).

vanilloid subfamily member 1 Binding (binds) of RTX associated with hyperalgesia, trp channel, qutenza and inflammation
9) Confidence 0.08 Published 2008 Journal Mol Pain Section Title Doc Link PMC2242785 Disease Relevance 0.92 Pain Relevance 0.61
Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain.
TRPV1 Binding (binds) of Resiniferatoxin associated with qutenza
10) Confidence 0.05 Published 2004 Journal Biochemistry Section Title Doc Link 14992587 Disease Relevance 0 Pain Relevance 0.76
Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain.
capsaicin receptor Binding (binds) of Resiniferatoxin associated with qutenza
11) Confidence 0.05 Published 2004 Journal Biochemistry Section Title Doc Link 14992587 Disease Relevance 0 Pain Relevance 0.76
Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both bind with higher affinity to the rat TRPV1 (rTRPV1) than the human (hTRPV1) isoform.
TRPV1 Binding (bind) of Resiniferatoxin associated with antagonist and agonist
12) Confidence 0.04 Published 2004 Journal Biochemistry Section Abstract Doc Link 14992587 Disease Relevance 0 Pain Relevance 0.61
Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both bind with higher affinity to the rat TRPV1 (rTRPV1) than the human (hTRPV1) isoform.
TRPV1 Binding (bind) of RTX associated with antagonist and agonist
13) Confidence 0.04 Published 2004 Journal Biochemistry Section Abstract Doc Link 14992587 Disease Relevance 0 Pain Relevance 0.60
Interestingly, RTX, a high affinity ligand for VR1, did alter regularly discharging BRs even at higher relative concentrations [20].
VR1 Binding (ligand) of RTX
14) Confidence 0.03 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.79
Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both bind with higher affinity to the rat TRPV1 (rTRPV1) than the human (hTRPV1) isoform.
rTRPV1 Binding (bind) of Resiniferatoxin associated with antagonist and agonist
15) Confidence 0.03 Published 2004 Journal Biochemistry Section Abstract Doc Link 14992587 Disease Relevance 0 Pain Relevance 0.61
Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both bind with higher affinity to the rat TRPV1 (rTRPV1) than the human (hTRPV1) isoform.
TRPV1 Binding (bind) of RTX associated with antagonist and agonist
16) Confidence 0.03 Published 2004 Journal Biochemistry Section Abstract Doc Link 14992587 Disease Relevance 0 Pain Relevance 0.59
To identify the structural features responsible for this difference in affinity, [(3)H]RTX binding to chimeras between hTRPV1 and rTRPV1 was characterized.
rTRPV1 Binding (binding) of RTX
17) Confidence 0.03 Published 2004 Journal Biochemistry Section Abstract Doc Link 14992587 Disease Relevance 0 Pain Relevance 0.61
Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both bind with higher affinity to the rat TRPV1 (rTRPV1) than the human (hTRPV1) isoform.
rTRPV1 Binding (bind) of RTX associated with antagonist and agonist
18) Confidence 0.03 Published 2004 Journal Biochemistry Section Abstract Doc Link 14992587 Disease Relevance 0 Pain Relevance 0.59

General Comments

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