INT106676

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Context Info
Confidence 1.6114138100
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in NULL
Documents 18
Total Number 18

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nucleoplasm (Phax) cytosol (Trpv1) RNA binding (Phax)
nucleus (Phax) plasma membrane (Trpv1) cytoplasm (Phax)
Anatomy Mention Frequency
neurons 3
spinal cord 1
paw 1
Trpv1 (Rattus norvegicus)
Phax (Rattus norvegicus)

Sentences Mentioned In

Key: Protein Event Anatomy Negation Speculation Pain term
Resiniferatoxin (RTX) has a much higher affinity for TRPV1 than capsaicin, but its ability to modulate excitatory transmission is unclear.
TRPV1 Binding (affinity) of RTX
1) Confidence 0.337430605132486 Published 2009 Journal N/A Section N/A Doc Link 19778582
Despite this activity and the high affinity of I-RTX for rat TRPV1, only capsazepine proved to be an effective antagonist of capsaicin-induced paw flinching in rats.
TRPV1 Binding (affinity) of RTX in paw
1) Confidence 0.259168494995643 Published 2002 Journal N/A Section N/A Doc Link 12438527
The binding of RTX leads to a sustained influx of sodium and calcium through TRPV1 channels [12] leading to channel desensitization and/or the loss of TRPV1-expressing DRG neurons and/or their fibers and terminals via calcium-induced cytotoxicity [13,14].
TRPV1 Binding (binding) of RTX in neurons
1) Confidence 0.114684148096938 Published 2010 Journal N/A Section N/A Doc Link PMC3019206
Resiniferatoxin (RTX), an ultrapotent capsaicin analog, is a vanilloid agonist that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1), a non-selective cation ion channel expressed in small- and medium-sized neurons in sensory ganglia [1-3].
vanilloid subfamily member 1 Binding (binds) of RTX in neurons
1) Confidence 0.111562652152031 Published 2008 Journal N/A Section N/A Doc Link PMC2242785
Resiniferatoxin (RTX), an ultrapotent capsaicin analog, is a vanilloid agonist that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1), a non-selective cation ion channel expressed in small- and medium-sized neurons in sensory ganglia [1-3].
TRPV1 Binding (binds) of RTX in neurons
1) Confidence 0.111562652152031 Published 2008 Journal N/A Section N/A Doc Link PMC2242785
These studies suggest that RTX binds to TRPV1 with high affinity and does not readily desensitize the receptor.
TRPV1 Binding (binds) of RTX
1) Confidence 0.0952481281773539 Published 2009 Journal N/A Section N/A Doc Link PMC2737142
Since RTX binds to TRPV1 irreversibly and with high affinity, we propose this property will aid in its localization in a given segment of the spinal cord by slow infusion using osmotic mini pumps.
TRPV1 Binding (binds) of RTX in spinal cord
1) Confidence 0.0952481281773539 Published 2009 Journal N/A Section N/A Doc Link PMC2737142
Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia

Resiniferatoxin (RTX) is an ultrapotent capsaicin analog that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1).

TRPV1 Binding (binds) of RTX
1) Confidence 0.0829568439079204 Published 2008 Journal N/A Section N/A Doc Link PMC2242785
Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia

Resiniferatoxin (RTX) is an ultrapotent capsaicin analog that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1).

vanilloid subfamily member 1 Binding (binds) of RTX
1) Confidence 0.0829568439079204 Published 2008 Journal N/A Section N/A Doc Link PMC2242785
Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain.
TRPV1 Binding (binds) of Resiniferatoxin
1) Confidence 0.0484003589688347 Published 2004 Journal N/A Section N/A Doc Link 14992587

General Comments

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