INT106731

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Context Info
Confidence 0.02
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MED1) small molecule metabolic process (MED1) cell morphogenesis (MED1)
nucleolus (MED1) nucleus (MED1) DNA binding (MED1)
Anatomy Link Frequency
fibroblasts 2
MED1 (Homo sapiens)
Pain Link Frequency Relevance Heat
peptic ulcer disease 2 64.60 Quite High
Disease Link Frequency Relevance Heat
Alagille Syndrome 4 94.12 High High
Gastritis 6 75.00 Quite High
Stomach Cancer 2 65.36 Quite High
Disease 2 64.60 Quite High
Ulcers 2 64.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cell cycle inhibition occurred concomitantly with an increase in p27(KIP1) protein levels, a reduction in Rb protein phosphorylation on serine residues 807-811, and a significant decrease in cyclin E-associated cdk2 activity.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of Rb protein
1) Confidence 0.02 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 12441136 Disease Relevance 0.56 Pain Relevance 0.06
In normal human fibroblasts, G1-phase cell accumulation was concomitant with the reduction in Rb protein phosphorylation; that, however, appeared to be dependent on p21(WAF1/CIP1) rather than on p27(KIP1) protein.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of Rb protein in fibroblasts
2) Confidence 0.02 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 12441136 Disease Relevance 0.39 Pain Relevance 0.05

General Comments

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