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Context Info
Confidence 0.22
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.30
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARRB1) plasma membrane (ARRB1) nucleus (ARRB1)
transcription factor binding (ARRB1) cytoplasm (ARRB1)
Anatomy Link Frequency
eosinophils 1
ARRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 8 97.88 Very High Very High Very High
antagonist 4 93.36 High High
agonist 4 86.16 High High
Cannabinoid receptor 1 81.44 Quite High
Opioid 3 76.64 Quite High
opioid receptor 6 75.00 Quite High
Immobilon 1 65.16 Quite High
Enkephalin 1 64.28 Quite High
tolerance 2 61.76 Quite High
Inflammation 1 60.92 Quite High
Disease Link Frequency Relevance Heat
Rhinitis 1 65.04 Quite High
Disease 1 61.28 Quite High
INFLAMMATION 2 60.92 Quite High
Glioma 1 57.16 Quite High
Neuroblastoma 1 56.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, attenuation of beta-arrestin1 function appears to depend on persistent stimulation of MAP kinase activity during the course of chronic morphine treatment, because coincubation of the cells together with the MAP kinase blocker PD98059 fully restored beta-arrestin1 translocation and receptor internalization.
Localization (translocation) of beta-arrestin1 associated with morphine
1) Confidence 0.22 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451120 Disease Relevance 0.11 Pain Relevance 1.04
In functional assays measuring inhibition of PGD2-mediated 1) guanosine 5'-O-(3-thio)triphosphate binding, 2) beta-arrestin translocation, and 3) shape change of human eosinophils endogenously expressing CRTH2, ramatroban, and TM30642 produced surmountable antagonism and parallel rightward shifts of the PGD2 concentration-response curves.
Localization (translocation) of beta-arrestin in eosinophils
2) Confidence 0.12 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16418339 Disease Relevance 0.19 Pain Relevance 0.17

General Comments

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