INT106972

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 36
Total Number 40
Disease Relevance 9.72
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (MAP2) cytoskeleton (MAP2) intracellular (MAP2)
cytoplasm (MAP2)
Anatomy Link Frequency
neuronal 9
neurons 6
neural 3
dendrites 2
astrocytes 2
MAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 46 99.52 Very High Very High Very High
cytokine 39 99.46 Very High Very High Very High
Dopamine 281 98.32 Very High Very High Very High
midbrain 91 98.20 Very High Very High Very High
Spinal cord 204 97.76 Very High Very High Very High
Central nervous system 60 94.56 High High
adenocard 4 89.04 High High
cocaine 292 88.88 High High
projection neuron 4 88.88 High High
GABAergic 6 83.96 Quite High
Disease Link Frequency Relevance Heat
Cancer 27 99.76 Very High Very High Very High
Primitive Neuroectodermal Tumors 4 98.16 Very High Very High Very High
Chronic Fatigue Syndrome 234 97.32 Very High Very High Very High
Infection 56 96.08 Very High Very High Very High
Obesity 78 93.96 High High
Gliosis 13 92.76 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 50 92.60 High High
Neuroblastoma 6 90.12 High High
Brain Injury 43 89.64 High High
Teratoma 26 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both tubulin and MAP2 are assumed to be synthesised in the cell body and transported by diffusion and active transport along the growing dendrites.
Gene_expression (synthesised) of MAP2 in cell body
1) Confidence 0.75 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1679805 Disease Relevance 0 Pain Relevance 0
40 years of age, there was a trend for lower MAP2 antibody levels for those that were ill for ?
Gene_expression (levels) of MAP2
2) Confidence 0.67 Published 2005 Journal J Autoimmune Dis Section Body Doc Link PMC1177983 Disease Relevance 0.92 Pain Relevance 0
Preparations of microtubule-associated protein 2 (MAP2) and neurofilament triplet (NFT) proteins were purchased from Sigma (St.
Gene_expression (Preparations) of MAP2
3) Confidence 0.67 Published 2005 Journal J Autoimmune Dis Section Body Doc Link PMC1177983 Disease Relevance 0.34 Pain Relevance 0
Preparations of microtubule-associated protein 2 (MAP2) and neurofilament triplet (NFT) proteins were purchased from Sigma (St.
Gene_expression (Preparations) of microtubule-associated protein 2
4) Confidence 0.67 Published 2005 Journal J Autoimmune Dis Section Body Doc Link PMC1177983 Disease Relevance 0.34 Pain Relevance 0
Such a substance can plausibly be identified as tubulin, or possibly a microtubule-associated protein, such as MAP2, that influences the stability of microtubule bundles in dendrites.
Gene_expression (identified) of MAP2 in dendrites
5) Confidence 0.65 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1679805 Disease Relevance 0 Pain Relevance 0
After plating, the rosette derived progenitors gave rise to an outgrowth of highly enriched bipolar cells expressing TUJ1, MUSASHI, NESTIN, A2B5, and MAP2 markers typically present in hESC-derived neural progenitors [14].
Gene_expression (expressing) of MAP2 in neural
6) Confidence 0.61 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0
We found the expression of human GAPDH, GFAP, NG2, TUJ1, and MAP2 but not in the control rats or nonlesioned part of the spinal cord (Supporting Information Fig. 5) confirming the presence of differentiated hESC.
Gene_expression (expression) of MAP2 in spinal cord associated with spinal cord
7) Confidence 0.53 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2996083 Disease Relevance 0.15 Pain Relevance 0.11
These cells finally matured to astrocytes, oligodendrocytes, and neurons (expressing GFAP, NG2, and TUJ1, respectively; Supporting Information Fig. 5) but only OPC and OPC + MP expressed human MAP2 (marker for postmitotic neurons), which is an additional proof of a triple fate of OPC and MP.


Gene_expression (expressed) of MAP2 in oligodendrocytes
8) Confidence 0.46 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2996083 Disease Relevance 0.32 Pain Relevance 0.11
At D28 the cells were positive for the following neuroectodermal markers: Nestin (data not shown), Musashi-1 (Figure 2B), A2B5 (Figure 2C) and MAP2 (Figure 2D).
Gene_expression (positive) of MAP2
9) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.12
Immunohistochemically, the tumor cells were positive for synaptophysin, nestin, microtubule-associated protein-2, CD56, CD10, glial fibrillary acidic protein (focal), and S-100 protein (focal).
Gene_expression (positive) of microtubule-associated protein-2 associated with cancer
10) Confidence 0.44 Published 2007 Journal Pathol. Int. Section Abstract Doc Link 17300673 Disease Relevance 1.09 Pain Relevance 0.20
Adult mesenchymal stem cells constitutively express native immature neural proteins (nestin and Tuj1), whereas more mature neuronal and glial proteins (tyrosine hydroxylase, MAP2, and GFAP) are expressed in increasing passage numbers [67,68].
Gene_expression (expressed) of MAP2 in stem cells
11) Confidence 0.44 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.06
g/ml for MAP2 staining) and Rhodamine Red X-conjugated goat anti-mouse IgG (5 ?
Gene_expression (staining) of MAP2
12) Confidence 0.39 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0 Pain Relevance 0.12
Genetical analysis also showed increased expression of additional neuronal cell type-specific markers, synaptophysin and MAP2.
Gene_expression (expression) of MAP2 in neuronal
13) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.05 Pain Relevance 0
By 6 weeks of culture in ES-ACM, most cells had neural morphology and expressed microtubule-associated protein 2 (MAP2) (Figure 3B).
Gene_expression (expressed) of MAP2 in neural
14) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708355 Disease Relevance 0 Pain Relevance 0
By 6 weeks of culture in ES-ACM, most cells had neural morphology and expressed microtubule-associated protein 2 (MAP2) (Figure 3B).
Gene_expression (expressed) of microtubule-associated protein 2 in neural
15) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708355 Disease Relevance 0 Pain Relevance 0
3) of cells expressed GFAP, and few (<1%) expressed MAP2.


Gene_expression (expressed) of MAP2
16) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708355 Disease Relevance 0 Pain Relevance 0.12
A1 hybrid neurons express neuron-specific markers such as neurofilament-L (NF-L), NF-M, NF-H, MAP-2, and beta tubulin III.
Gene_expression (express) of MAP-2 in neuron
17) Confidence 0.32 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12460557 Disease Relevance 0.32 Pain Relevance 0.15
At this time point, a large population (>60%) of cells expressed TBR1 (Figures 4A and 4F), a transcriptional factor expressed by glutamatergic neurons, and many TBR1+ neurons also expressed microtubule-associated protein 2 (MAP2), a mature neuron marker (Figure 4A).
Gene_expression (expressed) of microtubule-associated protein 2 in neuron
18) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0.05 Pain Relevance 0.27
At this time point, a large population (>60%) of cells expressed TBR1 (Figures 4A and 4F), a transcriptional factor expressed by glutamatergic neurons, and many TBR1+ neurons also expressed microtubule-associated protein 2 (MAP2), a mature neuron marker (Figure 4A).
Gene_expression (expressed) of MAP2 in neuron
19) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0.05 Pain Relevance 0.27
One of the cell lines, HM3.B10 (B10), was found to differentiate into neural cell types including neural stem cells, neurons, astrocytes and oligodendrocytes in vitro as shown by expression of genetic markers for neural stem cells (nestin and Musashi1), neurons (neurofilament protein, synapsin and MAP2), astrocytes (glial fibrillary acidic protein, GFAP) and oligodendrocytes (myelin basic protein, MBP) as determined by RT-PCR assay.
Gene_expression (expression) of MAP2 in astrocytes
20) Confidence 0.26 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2092394 Disease Relevance 0.66 Pain Relevance 0.18

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