INT10709

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2011
Negated 4
Speculated 5
Reported most in Abstract
Documents 106
Total Number 111
Disease Relevance 95.60
Pain Relevance 14.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T cells 37
lymphocyte 17
regulatory T cells 4
plasma 3
blood 2
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 524 100.00 Very High Very High Very High
abdominal pain 31 99.82 Very High Very High Very High
rheumatoid arthritis 650 99.80 Very High Very High Very High
spinal inflammation 72 99.68 Very High Very High Very High
fibrosis 50 99.62 Very High Very High Very High
methadone 24 99.04 Very High Very High Very High
Calcium channel 9 98.28 Very High Very High Very High
alcohol 150 98.26 Very High Very High Very High
Inflammation 526 97.80 Very High Very High Very High
depression 29 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 645 100.00 Very High Very High Very High
Immunodeficiency 78 100.00 Very High Very High Very High
Weight Loss 21 100.00 Very High Very High Very High
Bacterial Infection 27 99.96 Very High Very High Very High
Nicotine Addiction 7 99.96 Very High Very High Very High
Facial Paralysis 3 99.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3486 99.92 Very High Very High Very High
Infection 1540 99.92 Very High Very High Very High
Congenital Anomalies 83 99.90 Very High Very High Very High
Abdominal Pain 31 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A multivariate model was used to determine the impact on HRQL of the following factors: smoking, CD4 loss, acquired immune deficiency syndrome (AIDS) diagnoses, number of symptoms, study site, education, injection drug use, gender, and age.
Negative_regulation (loss) of CD4 associated with nicotine addiction and acquired immune deficiency syndrome or hiv infection
1) Confidence 0.59 Published 2001 Journal AIDS Patient Care STDS Section Abstract Doc Link 11788076 Disease Relevance 1.67 Pain Relevance 0.22
Long-term methadone use was associated with a significantly faster decrease of CD4+ count in HIV-1 affected patients compared with methadone non-users.
Negative_regulation (decrease) of CD4 associated with acquired immune deficiency syndrome or hiv infection and methadone
2) Confidence 0.59 Published 2001 Journal Eur J Pain Section Abstract Doc Link 11743707 Disease Relevance 0.59 Pain Relevance 0.84
Two of the seven HIV-seropositive patients presented with severe CD4 lymphocyte depletion.
Negative_regulation (depletion) of CD4 in lymphocyte associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.58 Published 1993 Journal Clin. Infect. Dis. Section Abstract Doc Link 8095162 Disease Relevance 1.70 Pain Relevance 0.28
CD4+-lymphocytes were rarely decreased.
Negative_regulation (decreased) of CD4 in lymphocytes
4) Confidence 0.58 Published 2005 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 15830313 Disease Relevance 0 Pain Relevance 0
Specifically, two sides of the observed association deserve further evaluation: 1) HIV induced CD4+ T cell loss directly correlated with the degree of HSV-2 activity or frequent symptomatic HSV-2 reactivations; and 2) active HSV-2 infection with frequent HSV-2 reactivations was, in turn, associated with modestly elevated plasma HIV RNA levels and reduced CD4+ T cell count over time, compared to women remaining clinically asymptomatic after adjusting for baseline CD4+ T cell levels.
Negative_regulation (loss) of CD4 in plasma associated with cold sores, acquired immune deficiency syndrome or hiv infection and infection
5) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848613 Disease Relevance 1.32 Pain Relevance 0
Bronchoalveolar lavage examination showed an increase in the percentage of lymphocytes and a decrease of CD4/CD8 ratio.
Negative_regulation (decrease) of CD4 in lymphocytes
6) Confidence 0.57 Published 1993 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 8121097 Disease Relevance 0.56 Pain Relevance 0.44
In our patient a decrease of T-helper cells and a significant lowered CD4/CD8 ratio could be detected.
Negative_regulation (decrease) of CD4 in T-helper cells
7) Confidence 0.57 Published 1995 Journal Neurol. Res. Section Abstract Doc Link 7477751 Disease Relevance 0.76 Pain Relevance 0.09
Biopsy of the mass demonstrated a high-grade B-cell non-Hodgkin's lymphoma, and the patient was classified in group IV-D of the human immunodeficiency virus infection because he had HIV serum antibodies and a reduced CD4/CD8 lymphocyte ratio.
Negative_regulation (reduced) of CD4 in lymphocyte associated with lymphatic system cancer and acquired immune deficiency syndrome or hiv infection
8) Confidence 0.57 Published 1991 Journal Med Clin (Barc) Section Abstract Doc Link 1895785 Disease Relevance 1.30 Pain Relevance 0.09
We treated the patient by lymphocytapheresis (LCP), which resulted in an improvement of his symptoms, a reduction in the CD4 lymphocyte population, a reduction of the CD4/CD8 ratio, and a reduced thickening of the dura mater that lasted for more than 14 months.
Negative_regulation (reduction) of CD4 in lymphocyte
9) Confidence 0.55 Published 2000 Journal Ther Apher Section Abstract Doc Link 10975480 Disease Relevance 0.86 Pain Relevance 0.26
CD4 levels are based on age and absolute counts and percentages, and will normally decrease over time in children.
Negative_regulation (decrease) of CD4
10) Confidence 0.53 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701488 Disease Relevance 1.32 Pain Relevance 0.10
Curiously, this observation was associated with a clear reduction in CD4+ T-cell number with age.
Spec (clear) Negative_regulation (reduction) of CD4 in T-cell
11) Confidence 0.50 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2698465 Disease Relevance 0.49 Pain Relevance 0
Oral thrush was not related to an accelerated rate of CD4% decline.
Negative_regulation (decline) of CD4 associated with candida infection
12) Confidence 0.43 Published 1993 Journal Am. J. Epidemiol. Section Abstract Doc Link 8100395 Disease Relevance 0.41 Pain Relevance 0.06
The rate of CD4% decline was approximately 1.2 CD4% lost per 6 months, with a higher rate in recent seroconverters (2.2 CD4% lost).
Negative_regulation (decline) of CD4
13) Confidence 0.43 Published 1993 Journal Am. J. Epidemiol. Section Abstract Doc Link 8100395 Disease Relevance 0.31 Pain Relevance 0.09
The most important predictors of decline of the CD4% in autoregressive models were current pyogenic bacterial infection (CD4% reduced by 2.75, 95% confidence interval (CI) 0.42-5.08), current report of a second constitutional symptom (CD4% reduced by 2.16, 95% CI 0.03-4.29), and history of bacterial infection (CD4% reduced by 1.49, 95% CI 0.09-2.89; proportion of prior CD4% lost increased by 0.14, 95% CI 0.01-0.27).
Negative_regulation (reduced) of CD4 associated with bacterial infection
14) Confidence 0.43 Published 1993 Journal Am. J. Epidemiol. Section Abstract Doc Link 8100395 Disease Relevance 0.34 Pain Relevance 0.08
The most important predictors of decline of the CD4% in autoregressive models were current pyogenic bacterial infection (CD4% reduced by 2.75, 95% confidence interval (CI) 0.42-5.08), current report of a second constitutional symptom (CD4% reduced by 2.16, 95% CI 0.03-4.29), and history of bacterial infection (CD4% reduced by 1.49, 95% CI 0.09-2.89; proportion of prior CD4% lost increased by 0.14, 95% CI 0.01-0.27).
Negative_regulation (reduced) of CD4 associated with bacterial infection
15) Confidence 0.43 Published 1993 Journal Am. J. Epidemiol. Section Abstract Doc Link 8100395 Disease Relevance 0.34 Pain Relevance 0.07
We suggest that this latter finding may be linked to declining CD4 T-lymphocyte levels in end-stage AIDS, and that CD4 T lymphocytes may be required for efficient entry of B lymphocytes to the CNS.
Negative_regulation (declining) of CD4 in CNS associated with acquired immune deficiency syndrome or hiv infection and central nervous system
16) Confidence 0.43 Published 2004 Journal J. Neurovirol. Section Abstract Doc Link 15204923 Disease Relevance 1.67 Pain Relevance 0.39
HIV serology was positive but there was no evidence of immunodepression or decreased CD4 lymphocyte levels.
Negative_regulation (decreased) of CD4 in lymphocyte associated with acquired immune deficiency syndrome or hiv infection
17) Confidence 0.43 Published 1996 Journal Med Trop (Mars) Section Abstract Doc Link 9026596 Disease Relevance 2.19 Pain Relevance 0.37
Experimental administration of the equivalent of heavy doses of alcohol as compared to sucrose to macaques infected with SIV was associated with early plasma CD4 cell loss in some studies [34, 35] but not others [36, 37], while several studies found greater SIV viral load at various times post-infection [19, 34, 36, 37].
Negative_regulation (loss) of CD4 in plasma associated with infection and alcohol
18) Confidence 0.43 Published 2010 Journal Curr HIV/AIDS Rep Section Body Doc Link PMC2938419 Disease Relevance 0.81 Pain Relevance 0.47
CD4 CD25high regulatory T cells are not impaired in patients with primary Sjögren's syndrome.
Negative_regulation (impaired) of CD4 in regulatory T cells associated with syndrome
19) Confidence 0.43 Published 2005 Journal J. Autoimmun. Section Title Doc Link 15848046 Disease Relevance 0.45 Pain Relevance 0.08
The results showed that off-pump CABG did not reduce the CD4+ cell count and did not affect the condition of HIV infection in this patient.
Neg (not) Negative_regulation (reduce) of CD4 associated with acquired immune deficiency syndrome or hiv infection and infection
20) Confidence 0.43 Published 2004 Journal Ann. Thorac. Surg. Section Abstract Doc Link 15172297 Disease Relevance 0.83 Pain Relevance 0.18

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