INT107129

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 46
Total Number 48
Disease Relevance 40.10
Pain Relevance 8.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 3
Brain 1
head 1
limb 1
central nervous system 1
RLS (Homo sapiens)
Pain Link Frequency Relevance Heat
sNRI 4 99.86 Very High Very High Very High
Dopamine 727 99.84 Very High Very High Very High
tolerance 42 99.68 Very High Very High Very High
withdrawal 24 99.60 Very High Very High Very High
cerebral cortex 2 99.52 Very High Very High Very High
biopsychosocial 9 99.40 Very High Very High Very High
Opioid 31 99.38 Very High Very High Very High
antagonist 35 99.32 Very High Very High Very High
depression 123 99.22 Very High Very High Very High
tramadol 4 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Restless Legs Syndrome 3254 100.00 Very High Very High Very High
Uremia 12 100.00 Very High Very High Very High
Suicidal Behaviour 3 99.88 Very High Very High Very High
Schizophrenia 63 99.84 Very High Very High Very High
Movement Disorders 37 99.80 Very High Very High Very High
Aneurism 7 99.60 Very High Very High Very High
Opiate Addiction 1 99.60 Very High Very High Very High
Anaemia 105 99.40 Very High Very High Very High
Disease 221 99.36 Very High Very High Very High
Chronic Renal Failure 14 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Perceived RLS severity was increased during menses in 29% of non-menopaused patients and 69% of the patients reported worsening of symptoms following menopause.
Positive_regulation (increased) of RLS
1) Confidence 0.60 Published 2008 Journal Sleep Med. Section Body Doc Link 17921056 Disease Relevance 0.07 Pain Relevance 0
In the study by Ondo (1999), IRLS Rating Scale scores significantly improved from 18.6±2.4 to 7.7±3.5, which is a robust finding given that the population was difficult to treat since the patients used an average total number of 4.2±1.8 medications for their RLS symptoms prior to entering the study and many had levodopa-induced RLS rebound during the study.
Positive_regulation (induced) of RLS associated with restless legs syndrome
2) Confidence 0.60 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671939 Disease Relevance 0.61 Pain Relevance 0
Brain iron deficiency might cause abnormalities in dopaminergic systems and, consequently, induce RLS symptoms.14
Positive_regulation (induce) of RLS in Brain associated with anaemia, congenital anomalies and restless legs syndrome
3) Confidence 0.57 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695234 Disease Relevance 1.11 Pain Relevance 0.15
The symptoms of RLS are aggravated in those with iron deficiency, and iron treatment ameliorates the symptoms in some patients.
Positive_regulation (aggravated) of RLS associated with anaemia and restless legs syndrome
4) Confidence 0.43 Published 2009 Journal Brain Nerve Section Abstract Doc Link 19514512 Disease Relevance 1.05 Pain Relevance 0.26
Genetic variants in four chromosomal regions have been identified that increase the risk of RLS.
Positive_regulation (increase) of RLS associated with restless legs syndrome
5) Confidence 0.43 Published 2010 Journal Nat Rev Neurol Section Abstract Doc Link 20531433 Disease Relevance 0.68 Pain Relevance 0.14
However, advanced brain imaging studies and positive results of dopaminergic treatment suggest that RLS may be generated by dopamine dysfunction locally within the central nervous system.
Spec (may) Positive_regulation (generated) of RLS in central nervous system associated with dopamine, central nervous system, restless legs syndrome and imagery
6) Confidence 0.43 Published 2009 Journal J. Intern. Med. Section Abstract Doc Link 19817966 Disease Relevance 0.93 Pain Relevance 0.37
The prevalence of RLS is lower in Japan than in studies conducted in European and North American populations.


Positive_regulation (prevalence) of RLS
7) Confidence 0.43 Published 2009 Journal Parkinsonism Relat. Disord. Section Body Doc Link 19346151 Disease Relevance 0 Pain Relevance 0
In one of the studies by Estivill and de la Fuente (1999b), significant improvement in the objective polysomnographic variables of sleep efficiency, total sleep time, and periodic limb movements were observed as well as subjective improvement in RLS symptoms, not only soon after the initiation of ropinirole treatment but also following a month of treatment.
Positive_regulation (improvement) of RLS in limb associated with restless legs syndrome
8) Confidence 0.43 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671939 Disease Relevance 0.60 Pain Relevance 0
Treatment of RLS and impact on biopsychosocial functioning
Positive_regulation (Treatment) of RLS associated with biopsychosocial and restless legs syndrome
9) Confidence 0.42 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671952 Disease Relevance 1.77 Pain Relevance 0.20
The RLS-6 scales showed an improvement of RLS symptoms at bedtime and during the night and a reduced tiredness during the day.
Positive_regulation (improvement) of RLS associated with fatigue and restless legs syndrome
10) Confidence 0.41 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695234 Disease Relevance 0.66 Pain Relevance 0
Differently from RLS, a circadian pattern of the clinical symptoms and a positive response to dopaminergic agents are lacking.
Positive_regulation (response) of RLS associated with restless legs syndrome
11) Confidence 0.41 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695234 Disease Relevance 1.39 Pain Relevance 0.66
Certain antidepressant drugs, including the selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), may induce or exacerbate RLS.
Spec (may) Positive_regulation (induce) of RLS associated with antidepressant, restless legs syndrome, snri, serotonin and ssri
12) Confidence 0.40 Published 2008 Journal Pharmacotherapy Section Abstract Doc Link 18225972 Disease Relevance 1.05 Pain Relevance 0.29
Several systemic disorders can cause RLS, and these should be identified and treated appropriately.
Positive_regulation (cause) of RLS associated with restless legs syndrome
13) Confidence 0.40 Published 2004 Journal Drugs Section Abstract Doc Link 14717617 Disease Relevance 0.84 Pain Relevance 0.20
Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs.
Positive_regulation (augmentation) of RLS associated with tramadol and restless legs syndrome
14) Confidence 0.40 Published 2007 Journal Mov. Disord. Section Abstract Doc Link 17230457 Disease Relevance 0.66 Pain Relevance 0.49
Based on this case and additional data published with other SSRIs and SNRIs, we believe that escitalopram should be added to the list of agents that can induce RLS.
Positive_regulation (induce) of RLS associated with restless legs syndrome, snri and ssri
15) Confidence 0.40 Published 2008 Journal Pharmacotherapy Section Abstract Doc Link 18225972 Disease Relevance 0.86 Pain Relevance 0.19
The occurrence of RLS correlated significantly with the intake of drugs that could potentially increase RLS severity.
Positive_regulation (increase) of RLS
16) Confidence 0.40 Published 2008 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 18186007 Disease Relevance 0.07 Pain Relevance 0
Importantly, a large proportion of patients with concurrent RLS and depression (35%) reported suicidal thoughts as a result of their RLS symptoms (Winkelmann et al 2005).


Positive_regulation (result) of RLS associated with suicidal behaviour, depression and restless legs syndrome
17) Confidence 0.39 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671952 Disease Relevance 2.73 Pain Relevance 0.34
In addition, the dopamine antagonist risperidone has been reported to induce RLS symptoms (Wetter et al 2002).
Positive_regulation (induce) of RLS associated with dopamine, antagonist and restless legs syndrome
18) Confidence 0.39 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671952 Disease Relevance 1.03 Pain Relevance 0.39
Because our sample size is relatively small, our data cannot exclude the possibility that TH Val81Met polymorphism has an influence on susceptibility to antipsychotic-induced RLS.
Positive_regulation (induced) of RLS associated with restless legs syndrome
19) Confidence 0.38 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796069 Disease Relevance 0.45 Pain Relevance 0
Therefore, we hypothesized TH to be associated with antipsychotic-induced RLS in schizophrenia patients.
Positive_regulation (induced) of RLS associated with restless legs syndrome and schizophrenia
20) Confidence 0.38 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796069 Disease Relevance 0.80 Pain Relevance 0.28

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