INT107216

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Context Info
Confidence 0.56
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.39
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
nerves 7
vessels 3
endothelial cells 2
dermis 2
hippocampus 2
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 62 100.00 Very High Very High Very High
Hippocampus 15 99.84 Very High Very High Very High
Inflammation 265 99.80 Very High Very High Very High
Potency 31 99.24 Very High Very High Very High
agonist 8 98.78 Very High Very High Very High
Pain 57 98.12 Very High Very High Very High
IPN 50 97.80 Very High Very High Very High
chemokine 135 89.76 High High
Antinociceptive 68 87.88 High High
ischemia 26 81.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 307 99.80 Very High Very High Very High
Pain 59 98.12 Very High Very High Very High
Inflammatory Pain 54 97.80 Very High Very High Very High
Epilepsy 4 95.84 Very High Very High Very High
Peritonitis 2 91.44 High High
Convulsion 3 90.60 High High
Neurodegenerative Disease 51 82.64 Quite High
Cv Unclassified Under Development 21 81.12 Quite High
Muscle Weakness 1 78.60 Quite High
Toxicity 1 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following oATP treatment, there was a reduction in P2X7 expression in the endings of peripheral nerves, as well as in endothelial cells.
Negative_regulation (reduction) of Gene_expression (expression) of P2X7 in endothelial cells
1) Confidence 0.56 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12483745 Disease Relevance 0.11 Pain Relevance 0
Treatment with local oATP, alone or after inflammatory reaction induced by carrageenan, showed a focal, irregular and mild reduction of P2X7 expression, often more prominent in areas with phlogosis both in nerves and in vessels.
Negative_regulation (reduction) of Gene_expression (expression) of P2X7 in nerves associated with inflammation
2) Confidence 0.36 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.34 Pain Relevance 0.17
Hind paws treated with intravenous oATP, alone or after inflammatory reaction induced by carrageenan, presented a reduced expression of P2X7, either in nerves, or close to epidermidis, in dermis or intramuscolar.
Negative_regulation (reduced) of Gene_expression (expression) of P2X7 in dermis associated with inflammation
3) Confidence 0.31 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.34 Pain Relevance 0.30
Few arterial vessels had a weak P2X7 positivity with a more prominent reduction in P2X7 expression in areas close to the inflammation site.
Negative_regulation (reduction) of Gene_expression (expression) of P2X7 in vessels associated with inflammation
4) Confidence 0.31 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.36 Pain Relevance 0.29
Our previous data suggested the possibility that the block of P2X7 receptors expressed by nerve terminals could be useful to inhibit pain transmission [3].
Negative_regulation (block) of Gene_expression (expressed) of P2X7 in nerve associated with pain
5) Confidence 0.27 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.42 Pain Relevance 0.35
Indeed, oATP could block such amplifying mechanism of inflammation and also downregulate P2X7 receptor expression, especially in vessels and nerves close to the site of inflammation (see Fig 4).
Negative_regulation (downregulate) of Gene_expression (expression) of P2X7 receptor in nerves associated with inflammation
6) Confidence 0.26 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.43 Pain Relevance 0.26
Fig. 4Arylhydrazide P2X7 antagonists
Negative_regulation (4Arylhydrazide) of Gene_expression (antagonists) of P2X7 associated with antagonist
7) Confidence 0.19 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0.09 Pain Relevance 0.37
Treatment with the GABAB receptor agonist baclofen and antagonist phaclofen resulted in increased and decreased P2X7 receptor expression in hippocampus, respectively [140].
Negative_regulation (decreased) of Gene_expression (expression) of P2X7 receptor in hippocampus associated with antagonist, agonist and hippocampus
8) Confidence 0.17 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.64 Pain Relevance 0.57
Indeed, oATP could block such amplifying mechanism of inflammation and also downregulate P2X7 receptor expression, especially in vessels and nerves close to the site of inflammation (see Fig 4).
Negative_regulation (downregulate) of in vessels Gene_expression (expression) of P2X7 receptor in nerves associated with inflammation
9) Confidence 0.09 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.43 Pain Relevance 0.26
PPADS added during OGD inhibited the expression of P2X1 and P2X6, but not P2X7.
Negative_regulation (inhibited) of Gene_expression (expression) of P2X7
10) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.23 Pain Relevance 0.04

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