INT107299

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 5.00
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
blood 2
cleavage 1
mononuclear cells 1
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 72 98.88 Very High Very High Very High
Osteoarthritis 1 95.00 High High
Morphine 6 94.96 High High
Inflammation 41 92.48 High High
withdrawal 3 87.64 High High
anticonvulsant 2 86.32 High High
cytokine 21 80.32 Quite High
Paracetamol 4 77.76 Quite High
metalloproteinase 18 75.44 Quite High
addiction 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 72 98.88 Very High Very High Very High
Apoptosis 69 97.00 Very High Very High Very High
Frailty 3 95.00 High High
INFLAMMATION 41 92.48 High High
Exanthema 4 91.32 High High
Death 10 91.00 High High
Bladder Cancer 91 90.88 High High
Corneal Neovascularization 2 90.72 High High
Hyperplasia 3 88.84 High High
Staphylococcus Infection 2 88.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Between 30% and 90% of cells in RA synovium are positive for Fas antigen, but Fas ligand (FasL) mRNA has been detected only in mononuclear cells in RA synovium [10].
Transcription (detected) of FasL in mononuclear cells associated with rheumatoid arthritis
1) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.92 Pain Relevance 0.43
Concurrently, a down-regulation of the proapoptotic proteins FasL and Bad was detected in cortical lysates.
Transcription (detected) of FasL
2) Confidence 0.63 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16496378 Disease Relevance 0.53 Pain Relevance 0.56
Subsequent experiments indicated that TCAH induced a mediated cleavage of FasL rather than suppressing FasL at the level of gene transcription [98].
Transcription (transcription) of FasL in cleavage
3) Confidence 0.32 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.18 Pain Relevance 0.20
In a review, Armstrong et al. [22] summarize a signal-transduction pathway in which a TSP1-stimulated CD36, an 88 kDa transmembrane glycoprotein, phosphorylates kinases p38 and JNK to induce transcription of FasL, which, when bound to Fas, leads to activation of caspases and results in apoptosis.
Transcription (transcription) of FasL associated with apoptosis
4) Confidence 0.30 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.65 Pain Relevance 0
IL-2, IL-4, IFN, TNF, perforin, granzyme B (GrB), and FasL mRNA expression levels were determined in peripheral blood mononuclear cells by competitive RT-PCR.
Transcription (levels) of FasL in blood
5) Confidence 0.07 Published 2002 Journal Blood Cells Mol. Dis. Section Abstract Doc Link 12490285 Disease Relevance 0.36 Pain Relevance 0.23
IL-2, IL-4, IFN, TNF, perforin, granzyme B (GrB), and FasL mRNA expression levels were determined in peripheral blood mononuclear cells by competitive RT-PCR.
Transcription (expression) of FasL in blood
6) Confidence 0.07 Published 2002 Journal Blood Cells Mol. Dis. Section Abstract Doc Link 12490285 Disease Relevance 0.36 Pain Relevance 0.22

General Comments

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