INT107407

Context Info Confidence 0.39 First Reported 2003 Last Reported 2009 Negated 1 Speculated 1 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 2.18 Pain Relevance 0.88

plasma membrane (KCNE1) lysosome (KCNE1)

Anatomy Link Frequency Heart 2 KCNE1 (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 2 98.72 beta blocker 4 98.20 addiction 4 92.52 opiate 4 92.12 Analgesic 2 90.52 Ultiva 1 86.44

Disease Link Frequency Relevance Heat Pressure Volume 2 Under Development 2 99.48 Heart Rate Under Development 6 99.32 Arrhythmia Under Development 2 96.72 Thyroid Crisis 4 94.88 Hypertension 2 93.16 Opiate Addiction 4 92.52 Mandibular Fractures 1 91.24 Delirium 1 85.52 Pneumothorax 1 84.80 Emergencies 2 82.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Heart rate was controlled around 90 beats x min(-1) using landiolol during surgery.

Regulation (controlled) of min in Heart

1) Confidence 0.39 Published 2008 Journal Masui Section Abstract Doc Link 18807903 Disease Relevance 1.16 Pain Relevance 0.17

Heart rate became controlled around 120 beats x min(-1) without hypotension during anesthesia.

Regulation (controlled) of min in Heart associated with anesthesia and pressure volume 2 under development

2) Confidence 0.39 Published 2009 Journal Masui Section Abstract Doc Link 20055204 Disease Relevance 0.68 Pain Relevance 0.19

The major active metabolite of l-alpha-acetylmethadol, noracetylmethadol, inhibited HERG with an estimated IC(50) values of 12 microM. l-alpha-acetylmethadol had little or no effect on Kv4.3 or KvLQT1/minK K(+) channel currents at concentration up to 10 microM.

Neg (no) Regulation (effect) of minK

3) Confidence 0.26 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12498903 Disease Relevance 0.15 Pain Relevance 0.29

To understand the mechanism underlying these clinical findings, we examined the effects of l-alpha-acetylmethadol on the cloned human cardiac K(+) channels HERG (human ether-a-go-go-related gene), KvLQT1/minK and Kv4.3.

Spec (examined) Regulation (effects) of minK

4) Confidence 0.19 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12498903 Disease Relevance 0.19 Pain Relevance 0.23

General Comments

This test has worked.