INT107407

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.18
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNE1) lysosome (KCNE1)
Anatomy Link Frequency
Heart 2
KCNE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 98.72 Very High Very High Very High
beta blocker 4 98.20 Very High Very High Very High
addiction 4 92.52 High High
opiate 4 92.12 High High
Analgesic 2 90.52 High High
Ultiva 1 86.44 High High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 2 99.48 Very High Very High Very High
Heart Rate Under Development 6 99.32 Very High Very High Very High
Arrhythmia Under Development 2 96.72 Very High Very High Very High
Thyroid Crisis 4 94.88 High High
Hypertension 2 93.16 High High
Opiate Addiction 4 92.52 High High
Mandibular Fractures 1 91.24 High High
Delirium 1 85.52 High High
Pneumothorax 1 84.80 Quite High
Emergencies 2 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heart rate was controlled around 90 beats x min(-1) using landiolol during surgery.
Regulation (controlled) of min in Heart
1) Confidence 0.39 Published 2008 Journal Masui Section Abstract Doc Link 18807903 Disease Relevance 1.16 Pain Relevance 0.17
Heart rate became controlled around 120 beats x min(-1) without hypotension during anesthesia.
Regulation (controlled) of min in Heart associated with anesthesia and pressure volume 2 under development
2) Confidence 0.39 Published 2009 Journal Masui Section Abstract Doc Link 20055204 Disease Relevance 0.68 Pain Relevance 0.19
The major active metabolite of l-alpha-acetylmethadol, noracetylmethadol, inhibited HERG with an estimated IC(50) values of 12 microM. l-alpha-acetylmethadol had little or no effect on Kv4.3 or KvLQT1/minK K(+) channel currents at concentration up to 10 microM.
Neg (no) Regulation (effect) of minK
3) Confidence 0.26 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12498903 Disease Relevance 0.15 Pain Relevance 0.29
To understand the mechanism underlying these clinical findings, we examined the effects of l-alpha-acetylmethadol on the cloned human cardiac K(+) channels HERG (human ether-a-go-go-related gene), KvLQT1/minK and Kv4.3.
Spec (examined) Regulation (effects) of minK
4) Confidence 0.19 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12498903 Disease Relevance 0.19 Pain Relevance 0.23

General Comments

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